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The inefficiency of in vivo gene transfer using currently available vectors reflects a major hurdle in cancer gene therapy. Both viral and non-viral approaches that improve gene transfer efficiency have been described, but suffer from a number of limitations. Herein, a fiber-modified adenovirus, carrying the small peptide ligand on the capsid, was tested for the delivery of a transgene to cancer cells. The fiber-modified adenovirus was able to mediate the entry and expression of a $\beta$-galactosidase into cancer cells with increased efficiency compared to the unmodified adenovirus. Particularly, the gene transfer efficiency was improved up to 5 times in OVCAR3 cells, an ovarian cancer cell line. Such transduction systems hold promise for delivering genes to transferrin receptor overexpressing cancer cells, and could be used for future cancer gene therapy.

참고문헌 (15)

  1. Hong, J.S. and J. A. Engler, 1996. Domains required for assembly of adenoviurs type 2 fiber trimers, J. Virol. 70, 7071-7078 
  2. Joung, I., H.S. Kim, J.S. Hong, H. Kwon, and Y.K. Kwon, 2000. Effective gene transfer into regeneration sciatic nerves by adenoviral vector: potentials for gene therapy of peripheral nerve injury. Mol. Cells 10, 540-545 
  3. Joung, I., G. Harber, K.M. Gerecke, S.L. Carroll, J.F. Collawn, and J. A. Engler, 2005. Improved gene delivery into neuroglial cells using a fiber-modified adenovirus vector. Biochem. Biophys. Res. Commun. 328, 1182-1187 
  4. Michael, S.I., J.S. Hong, D.T. Curiel, and J.A. Engler, 1995. Addition of a short peptide ligand to the adenovirus fiber protein. Gene Ther. 2, 660-668 
  5. Miyamoto, T., N. Tanaka, Y. Eishi, and T. Amagasa, 1994. Transferrin receptor in oral tumors. Int. J. Oral Maxillofac. Surg. 23, 430-433 
  6. Wen, D.Y., W.A. Hall, and O. Fodstad, 1993. Rapid detection of transferrin receptor expression on glioma cell lines by using magnetic microspheres. Neurosurgery 33, 878-881 
  7. Keer, H.N., J.M. Kozlowshi, Y.C. Tsai, C. Lee, R.N. McEwan, and J.T. Grayhack, 1990. Elevated transferrin receptor content in human prostate cancer cell lines assessed in vitro and in vivo. J. Urol. 143, 381-385 
  8. Wickham, T. J., 2000. Targeting adenovirus. Gene Ther. 7, 110-114 
  9. Curiel, D.T., S. Agarwal, E. Wagner, and M. Cotten, 1991. Adenovirus enhancement of transferrin-polylysine-mediated gene delivery. Proc. Natl. Acad. Sci. USA 88, 8850-8854 
  10. Li, H., H. Sun, and Z.M. Qian, 2002. The role of the transferrintransferrin- receptor system in drug delivery and targeting. Trends Pharmacol. Sci. 23, 206-209 
  11. Xu, L., C.-C. Huang, W. Huang, W.-H. Tang, A. Rait, Y.Z. Yin, I. Cruz, L.-M. Xiang, K.F. Pirollo, and E.H. Chang. 2002. Systemic tumor-targeted gene delivery by anti-transferrin receptor scFv-immunoliposomes. Mol. Cancer Ther. 1, 337-346 
  12. Krasnykh, V., I. Dmitriev, J.G. Navarro, N. Belousova, E. Kashentseva, J. Xiang, J.T. Douglas, and D.T. Curiel, 2000. Advanced generation adenoviral vectors possess augmented gene transfer efficiency based upon coxsackie adenovirus receptor-independent cellular entry capacity. Cancer Res. 60, 6784-6787 
  13. Ryschich, E., G. Huszty, H.P. Knaebel, M. Hartel, M.W. Buchler, and J. Schmidt, 2004. Transferrin receptor is a marker of malignant phenotype in human pancreatic cancer and in neuroendocrine carcinoma of the pancreas. Eur. J. Cancer 40, 1418-1422 
  14. Wagner, E., K. Zatloukal, M. Cotten, H. Kirlappos, K. Mechtler, D.T. Curiel, and M. L. Birnstiel, 1992. Coupling of adenovirus to transferrin-polylysine/DNA complexes greatly enhances receptor-mediated gene delivery and expression of transfected genes. Proc. Natl. Acad. Sci. USA 89, 6099-6103 
  15. Benihoud, K., P. Yeh, and M. Perricaudet, 1999. Adenovirus vectors for gene delivery. Curr. Opin. Biotechnol. 10, 440-447 

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