[논문]Effect of Psyllium Seed Husk on the Postprandial Glucose Control and Insulin Secretion Dynamics

Choi Hyun-Ju; Nam Jeong-Su

Effect of Psyllium Seed Husk on the Postprandial Glucose Control and Insulin Secretion Dynamics 원문보기

Nutritional sciences, v.8 no.2, 2005년, pp.83 - 88

Choi Hyun-Ju (Department of Biomedical Laboratory Science, Biohealth Products Research Center, Food Science Institute, Diet Research Center, Inje University) , Nam Jeong-Su (Department of Biomedical Laboratory Science, Biohealth Products Research Center, Food Science Institute, Diet Research Center, Inje University)

Abstract ▼ AI-Helper

This study was to investigate the effect of psyllium seed husk (PSYL) on postprandial glucose control and insulin secretion dynamics in Sprague-Dawley rats. In experiment 1, the rise in postprandial serum glucose was monitored during a 240-min period using a maltose loading test In normal rats given 16.6 mg/l00 g B.W./ml of PSYL orally, all the blood glucose levels during the 240-min period did not show statistically significant differences from the corresponding levels in normal rats given water. However, in streptozotocin-induced diabetic rats given the same amount of PSYL, the blood glucose level at 30 min was significantly lower than that in diabetic rats given water, and the peak time of the rise in the postprandial glucose was delayed In experiment 2, the normal (N) and diabetic (Db) rats were given PSYL (25 mg/l00 g B.W./ml/day) orally for 5 days. Blood samples were collected in order to measure the s-glucose and s-insulin levels. The final s-glucose level at day 5 in Db-PSYL was significantly lower than that in the corresponding control rats (Db-CONT) and the final s-insulin level in Db-PSYL was significantly greater than that in Db-CONT. In vitro 40-min pancreas perfusion was performed at day 5 in order to examine the insulin secretion dynamics. Results showed that the amounts of insulin secreted during the first phase (11-20 min) and the second phase (21-40 min) in the Db-PSYL were significantly greater than those in Db-CONT. Therefore, it is concluded that psyllium seed husk could be beneficial for controlling postprandial glucose levels in the stretozotocin-induced diabetic rats, and it may be partially mediated by insulin secretion dynamics.

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가설 설정

18) It has been reported that the water-soluble, gel-forming fiber such as guar gum, gum tragacanth reduce the expected rise in 흥lucose levels after the glucose solution or me이 ingestion in normal subjects and individuals with type 1 and 2 diabetes.H) Possible explanation for the mechanisms for the postprandial glucose response after psyllium feeding is that the properties of psyllium as a soluble fiber modify the digestion and absorption of maltose in the small intestine. Indeed, Sierra et al.

제안 방법

Diabetes was induced as described in the experiment 1. Rats were divided into four groups (n=6/group): normal rats on psyllium seed husk (N-PSYL), normal rats on water as a control group (N-CONT), diabetic rats on psyllium seed husk (Db-PSYL), and diabetic rats on water as a control group (Db-CONT). Rats in PSYL groups were fed on natural psyllium seed husk (Procter & Gamble, Cincinnati, OH, USA, 25 mg/100 g B.

성능/효과

In conclusions, our results showed that the psyllium seed husk had a beneficial effect for the postprandial blood control, thus psyllium seed husk can be used as a diet supplement with meal. Psyllium appears to restore the insulin secretory dynamics, however, further studies with pancreatic p-cells are needed to clarify its effects and the mechanism involved.
7 times greater than that in Db-CONT. These data showed that PSYL significantly stimulated the insulin secretion from the pancreas in the diabetic rats, although the absolute amount was still in the lower range when compared to those in the non-diabetic normal rats.

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