[논문]The Plasma and Urinary Carnitine System in Korean Diabetic Patients

Lee Yeoul; Heo Young Ran; Cha Youn Soo

The Plasma and Urinary Carnitine System in Korean Diabetic Patients 원문보기

Nutritional sciences, v.8 no.2, 2005년, pp.97 - 103

Lee Yeoul (Department of Food Science and Nutrition and Research Institute of Human Ecology, Chonbuk National University) , Heo Young Ran (Department of Food and Nutrition, Collage of Human Ecology Chonnam National University) , Cha Youn Soo (Department of Food Science and Nutrition and Research Institute of Human Ecology, Chonbuk National University)

Abstract ▼ AI-Helper

The goal of this study was to investigate abnotmalities in camitine metabolism present by determining blood camitine and lipid concentrations in Korean diabetic patients. The study subjects included 108 Korean diabetic patients (64 males and 44 females) who were hospitalized in Chonbuk National University Hospital and 27 subjects were also hospitalized as non-diabetic controls (10 males and 17 females). Glucose, total cholesterol, triglyceride (TG) and HDL-cholesterol in plasma were enzymatically assayed and insulin was measured by immunoradiometric assay. Nonesterified camitine (NEC), acid-soluble acylcarnitine (ASAC), and acid-insoluble acylcarnitine (AIAC) were determined by a modified radioisotopic method Glucose and insulin levels were significantly elevated in diabetic patients compared with controls. Total cholesterol was elevated in female but not male diabetic patients and triglycerides were elevated both in male and female diabetics. Plasma and urinary total carnitine (TCNE) were significantly elevated in diabetics as compared with normal controls. In male diabetics, NEC concentrations were significantly elevated above controls, but not in female subjects. Plasma NEC and TCNE concentrations were significantly increased in male diabetics, but significantly decreased in female diabetics. All urinary carnitine concentrations were significantly increased in diabetics as compared with controls. Urinary NEC concentrations were four times higher in male diabetics and three times higher in female diabetics than in controls. The ratios of serum and urinary acylcarnitine/NEC were also significantly higher in diabetics than in controls. This study suggested that there was a remarkable abnormality in lipid and carnitine metabolism in Korean diabetic patients, and the further study on carnitine metabolism and the effects of carnitine supplementation for Korean diabetic patients are needed.

주제어

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제안 방법

In this study, we measured carnitine and lipid profiles in the blood and urine from Korean diabetic patients and investigated the relationships between these two metabolic variables. We also compared these variables according to the criteria of diabetes defined by fasting and postprandial glucose levels that the American Diabetic Association suggests?
Diabetic patients with coronary heart disease, chronic renal failure, liver cirrhosis and severe nutritional deficiency were excluded. Patients were grouped into three groups; fasting hyperglycemia (FHG, 目 120 mg/dL), postprandial hyperglycemia (PHG, W 260 mg/dL) and overt hyperglycemia (OHG, FHG and PHG).

대상 데이터

The study subjects included 108 Korean diabetic patients (64 males and 44 females) who were hospitalized in Chonbuk National University Hospital and the 27 subjects were also hospitalized as non-diabetic controls (10 males and 17 females). Diabetic patients with coronary heart disease, chronic renal failure, liver cirrhosis and severe nutritional deficiency were excluded.

데이터처리

Values are mean±SD. Values with different superscripts are significantly different by ANOVA with Duncan's multiple range test at P<0.05.

이론/모형

, Seoul Korea). HDL-cholesterol was measured by the sedimentation enzymatic method and LDL-cholesterol was calculated by the Friedewald formula: total cholesterol -(triglyceride/5 + HDL-cholesterol).
Plasma total cholesterol (TC) levels were measured by using commercial kits (Asan Pharm. Co., Seoul, Korea) based on the cholesterol oxidase method. Serum triglyceride levels were measured by the lipase-glycerol phosphate method using commercial kits (Asan Pharm.
, Seoul, Korea) based on the cholesterol oxidase method. Serum triglyceride levels were measured by the lipase-glycerol phosphate method using commercial kits (Asan Pharm. Co., Seoul Korea). HDL-cholesterol was measured by the sedimentation enzymatic method and LDL-cholesterol was calculated by the Friedewald formula: total cholesterol -(triglyceride/5 + HDL-cholesterol).
, Seoul, Korea). The fasting plasma insulin (FPI) and postprandial plasma insulin (PPI) levels were measured by imniunoradiometric method (Pharmacia Corp., Uppsala, Sweden).

성능/효과

1-3) Type 2 diabetes (formerly named non-insulin-dependent diabetes) is resulted from the body's inability to respond properly to the action of insulin produced by the pancreas.3, 4) Type 2 diabetes is much more common in frequency and accounts for around 90% of all diabetes cases worldwide. It occurs most frequently in adults, but is being noted increasingly in adolescents as well.

후속연구

However, the interesting thing is that especially FHG had significantly higher HDL-cholesterol than other PHG and OHG. Further study is needed to explain this metabolic status, because we could not find any significant correlation with glucose, insulin, lipid and other variables determined. One of the mechanisms that explained dyslipidemia in diabetes has been proposed.
For clinical use, it is an important finding that carnitine is effective in lowering blood glucose and improving glucose tolerance ability by oral administration. In conclusion, this study suggested that there are remarkable abnormalities in blood glucose, insulin and lipid as well as camitme metabolism in Korean diabetic patients, and the further study on carnitine metabolism and the effects of carnitine supplementation for Korean diabetic patients is needed.

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