$\require{mediawiki-texvc}$
  • 검색어에 아래의 연산자를 사용하시면 더 정확한 검색결과를 얻을 수 있습니다.
  • 검색연산자
검색연산자 기능 검색시 예
() 우선순위가 가장 높은 연산자 예1) (나노 (기계 | machine))
공백 두 개의 검색어(식)을 모두 포함하고 있는 문서 검색 예1) (나노 기계)
예2) 나노 장영실
| 두 개의 검색어(식) 중 하나 이상 포함하고 있는 문서 검색 예1) (줄기세포 | 면역)
예2) 줄기세포 | 장영실
! NOT 이후에 있는 검색어가 포함된 문서는 제외 예1) (황금 !백금)
예2) !image
* 검색어의 *란에 0개 이상의 임의의 문자가 포함된 문서 검색 예) semi*
"" 따옴표 내의 구문과 완전히 일치하는 문서만 검색 예) "Transform and Quantization"
쳇봇 이모티콘
안녕하세요!
ScienceON 챗봇입니다.
궁금한 것은 저에게 물어봐주세요.

논문 상세정보

Vitamin D Sufficiency: How Should it be Defined and what are its Functional Indicators

Nutritional sciences v.8 no.2 , 2005년, pp.111 - 117  
Abstract

It has been more than three decades since the first assay assessing circulating 25 (OH)D in human subjects was performed That publication as well as several that followed it defined 'normal' nutritional vitamin D status in human populations. Recently, the wisdom by which 'normal' circulating 25 (OH)D levels in human subjects were assigned in the past has come under question. It appears that sampling human subjects, who appear to be free from disease, and assessing 'normal' circulating 25 (OH)D levels by plotting a Gaussian distribution is grossly inaccurate. There are many reasons why this method is inaccurate, including race, lifestyle habits, sunscreen usage, age, latitude, and inappropriately low dietary recommendations for vitamin D. For instance, a 400 IU/day. AI for vitamin D is insignificant when one considers that a 10-15 minute whole body exposure to peak summer sun will generate and release up to 20,000 IU vitamin $D_3$ into the circulation. Recent studies, which orally administered up to 10,000 IU/day vitamin $D_3$ to human subjects for several months, have successfully elevated circulating 25 (OH)D levels to those observed in individuals from sun-rich environments. Further, we are now able to accurately assess sufficient circulating 25 (OH)D levels utilizing specific biomarkers instead of guessing what an adequate level is. These biomarkers include intact parathyroid hormone (PTH), calcium absorption, bone mineral density (BMD), insulin resistance and pancreatic beta cell function. Using the data from these biomarkers, vitamin D deficiency should be defined as circulating levels of 25 (OH)D$\leq$30 ng/mL. In certain cases, such as pregnancy and lactation, significantly higher circulating 25 (OH)D levels would almost certainly be beneficial to both the mother and recipient fetus/infant.

참고문헌 (29)

  1. Matsuoka LY, Wortsman J, Hollis BW. Lack of effect of exogenous calcitriol on cutaneous production of vitamin $D_{3}$. J Clin Endocrinal Metab 66:451-453, 1988 
  2. Matsuoka LY, Wortsman J, Hollis BW. Use of topical sunscreen for the evaluation of regional synthesis of vitamin $D_{3}$. J Amer Acad Dermatol 22:772-775, 1990 
  3. Matsuoka LY, Wortsman J, Dannenberg MJ, Hollis BW, Lu Z, Holick MF. Clothing prevents ultraviolet-B-radiation-dependent photosynthesis of vitamin $D_{3}$. J Clin Endocrinol Metab 75:1099-1103, 1992 
  4. Clemens TL, Henderson SL, Adams JS, Holick MF. Increased skin pigment reduces the capacity of skin to synthesize vitamin $D_{3}$. Lancet 9:74-76, 1982 
  5. Matsuoka LY, Wortsman J, Hanifan N, Holick MF. Chronic sunscreen use decreases circulating concentrations of 25-hydroxyvitamin D: A preliminary study. Arch Dermatol 124:1802-1804, 1988 
  6. Gloth FM, Tobin JD, Sherman SS, Honis BW. Is the recommended daily allowance for vitamin D too low for the homebound elderly? J Am Geriatric Soc 39:137-141, 1991 
  7. Heaney R, Dowen M, Hale C, Bendich A. Calcium absorption varies within the reference range for serum 25-hydroxyvitamin D. J Amer College Nutr 22(2):142-146, 2003 
  8. Meier C, Woitge H, Witte K, Lemmer B, Seibel M. Supplementation with oral vitamin $D_{3}$ and calcium during winter prevents seasonal bone loss: A randomized controlled open-label prospective trial. J Bone Mineral Res 19:1221-1230, 2004 
  9. Zittermann A. Vitamin D in preventive medicine: Are we ignoring the evidence? Brit J Nutrition 89:552-572, 2003 
  10. Trivedi D, Doll R, Khan K. Effect of four monthly oral vitamin $D_{3}$ supplementation on fractures and mortality in men and, women living in the community: randomized double blind controlled trial. Brit Med J 326:469-474, 2003 
  11. Mawer E, Davies M. Bone disorders associated with gastrointestinal and hepatobiliary disease. In: Feldman D, Glorieux F, Pike J (eds.) Vitamin D. Academic Press. San Diego, CA, pp.831-847, 1996 
  12. Chapuy MC, Arlot M, DuBoeuf F, Brun J, Crouzet B, Arnaud S, Delmas PD, Meunier PJ. Vitamin $D_{3}$ and calcium to prevent hip fractures in the elderly woman. N Engl J Med 327:1637-1642, 1992 
  13. Holick MF. Photobiology of vitamin D. In: Feldman D, Glorieux FH, Pike JW (eds.) Vitamin D. Academic Press. San Diego, CA, pp.33-39, 1996 
  14. Webb AR, Kline L, Holick MF. Influence of season and latitude on the cutaneous synthesis of vitamin $D_{3}$ synthesis in human skin. J Clin Endocrinal Metab 67:373-378, 1988 
  15. Lark R, Lester G, Ontjes D, Blackwood A, Hollis BW, Hensler M, Aris R. Diminished and eratic absorption of ergocalciferol in adult cystic fibrosis patients. Am J Clin Nutr 73:602-606, 2001 
  16. Haddad JG, Matsuoka LY, Hollis BW, Hu Y, Wortsman J. Human plasma transport of vitamin D after its endogenous synthesis. J Clin Invest 91(6):2552-2555, 1993 
  17. Matsuoka LY, Wortsman J, Haddad JG, Hollis BW. In vivo threshold for cutaneous synthesis of vitamin $D_{3}$. J Lab Clin Med 114:301-305, 1989 
  18. Vieth R, Ladak Y, Walfish P. Age-related changes in the 25-hydroxyvitamin D versus parathyroid hormone relationship suggest a different reason why older adults require more vitamin D. J Clin Endocrinal Metab 88:185-191, 2003 
  19. Holick MF, MacLaughlin JA, Doppelt SH. Factors that influence the cutaneous photosynthesis of previtamin $D_{3}$. Science 211:590-593, 1981 
  20. Chiu K, Chu A, Go V, Soad M. Hypovitaminosis D is associated with insulin resistance and beta cen dysfunction. Amer J Clin Nutr 79:820-825, 2004 
  21. Bischoff-Ferrari H, Dietrich T, Orav E, Dawson-Hughes B. Positive association between 25 (OH)D levels and bone mineral density: A population-based study of younger and older adults. Amer J Med 116:634-639, 2004 
  22. Passeri G, Pini G, Troiano L, Vescovini R, Sansoni P, Passeri M, Gueresi P, Delsignore R, Pedrazzoni M, Franceschi C. Low vitamin D status, high bone turnover, and bone fractures in centenarians. J Clin Endocrinal Metab 88:5109-5115, 2003 
  23. Haddad JG, Chyu K. Competitive protein-binding radioassay for 25-hydroxycholecalciferol. J Clin Endocrinal Metab 33:992-995, 1971 
  24. Heaney RP, Davies KM, Chen TC, Holick MF, Barger-Lux MJ. Human serum 25-hydroxycholecalciferol response to extended oral dosing with cholecalciferol. Am J Clin Nutr 77:204-210, 2003 
  25. MacLaughlin JA, Holick MF. Aging decreases the capacity of the skin to produce vitamin $D_{3}$. J Clin Invest 76:1536-1538, 1985 
  26. Sherman SS, Hollis BW, Tobin J. Vitamin D status and related parameters in a healthy population: The effects of age, sex and season. J Clin Endocrinal Metab 71:405-413, 1990 
  27. Matsuoka LY, Wortsmann J, Haddad JG, Kolm P, Hollis BW. Racial pigmentation and the cutaneous synthesis of vitamin D. Arch Dermatol 127:536-538, 1991 
  28. Holick MF. Vitamin D: Importance in the prevention of cancers, type 1 diabetes, heart disease, and osteoporosis. Am J Clin Nutr 79:362-371, 2004 
  29. Haddock L, Corcino J, Vazquez MD. 25 (OH)D serum levels in the normal Puerto Rican population and in subjects with tropical sprue and parathyroid disease. Puerto Rico Health Science 1:85-91, 1982 

이 논문을 인용한 문헌 (0)

  1. 이 논문을 인용한 문헌 없음

원문보기

원문 PDF 다운로드

  • ScienceON :

원문 URL 링크

원문 PDF 파일 및 링크정보가 존재하지 않을 경우 KISTI DDS 시스템에서 제공하는 원문복사서비스를 사용할 수 있습니다. (원문복사서비스 안내 바로 가기)

상세조회 0건 원문조회 0건

DOI 인용 스타일