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This study was undertaken to determine the antagonism of the ginseng total saponin (GTS) on the development of nalbuphine-induced tolerance and physical dependence. GTS is blown to have antinarcotic action with a dose of 100mg/kg (i.p.) in rats. STS significantly inhibits the development of nalbuphine-induced physical dependence as well as the tolerance. The level of pCREB was elevated in the striatum by the chronic treatment with nalbuphine or GTS, how-ever, the elevation of pCREB was inhibited by the GTS co-treatment. It has been suggested that NMDA receptor and/or NO is involved in the penomena of opioid dependence and withdrawal. However, the level of nNOS and NR1 was not modulated by the treatment with nalbuphine or GTS on the cortex, hippocampus and striatum in the rat brain. These results suggest that the GTS could be used to ameliorate the nalbuphine tolerance and withdrawal symptoms.

참고문헌 (20)

  1. Walker, E.A. and Young, A.M.: Discriminative-stimulus effects of the low efficacy agonist nalbuphine. J. Pharmacol Exp. Ther. 267, 322-330 (1993) 
  2. Chen, J.C., Smith, E.R., Cahill, M., Cohen, R. and Fishman, J.R.: The opioid receptor binding of pentazocine, morphine, fentanyl, butorphanol and nalbuphine. Life Sci. 52, 389-396 (1992) 
  3. Schmidt, W.K., Tam, S.W., Shotzberger, G.S., Smith, D.H. Jr, Clark, R. and Vemier, V.G.: Nalbuphine. Drug Alcohol Depend. 14, 339-362 (1985) 
  4. Penning, J.P., Samson, B., Baxter, A.D.: Reversal of epidural morphine-induced respiratory depression and pruritus with nalbuphine. Can. J. Anaesth. 35, 599-604 (1988) 
  5. Cuellar, B., Fernandez, A.P., Lizasoain, l., Moro, M.A., Lorenzo, P., Bentura, M.L., Rodrigo, J. and Leza, J.C.: Upregulation of neuronal NO synthase immunoreactivity in opiate dependence and withdrawal. Psychopharmacology (Berl.) 148, 66-73 (2000) 
  6. Koyuncuoglu, H., Dizdar, Y., Aricioglu, F. and Sayin, U.: Efects of MK-801 on morphine physical dependence: attenuation and intensification. Pharmacol. Biochem. Behav. 43, 484-490 (1992) 
  7. Tokuyama, S., Wakabayashi, H. and Ho, I.K.: Direct evidence for a role of glutamate in the expression of opioid withdrawal syndrome. Eur. J. Pharmacol. 295, 123-129 (1996) 
  8. Noda, Y., Yamada, K., Komori, Y., Sugihara, H., Furukawa, H., Nabeshima, T.: Role of nitric oxide in the development of tolerance and sensitization to behavioral effects of phencyclidine in mice. Br. J. Pharmacol. 204, 339-340 (1996) 
  9. Kim H. S., Kang, J. G. and Oh, K. W: Inhibition of ginseng total saponin of the development of morphine reverse tolerance and dopamine receptor supersensitivity in mice. Gen. Pharmacol. 26,1071-1076 (1995a) 
  10. Tokuyama, S., Oh, K. W., Kim, H. S., Takahashi, M., and Kaneto, H.: Blockade by ginseng extract of the development of reverse tolerance to the ambulation-accelerating effect of methamphetamine in mice. Jpn. J. Pharmacol. 59, 423-425 (1992) 
  11. Kim, H. S., Kang J. G., Seong Y. H., Nam K. Y. and Oh, K. W.: Blockade by ginseng total saponin of the development of cocaine induced reverse tolerance and dopamine receptor supersensitivity in mice. Pharmacol. Biochem. Behav. 50, 23-27 (1995b) 
  12. Nagamatsu, K., Kido, Y., Terao, T., Ishida, T. and Toki, S.: Studies on the mechanism of covalent binding of morphine metabolites to proteins in mouse. Drug Meta. Dispos. 11, 190-194 (1983) 
  13. D'Amour, F.E. and Smith, D.L.: A method for determining loss of pain sensation. J. Pharmacol. Exp. Ther. 72, 74-79 (1942) 
  14. Ellman, G.L.: Tissue sulfhydryl compounds on acute toxicity of morphinone. Arch. Biochem. Biophys. 82, 70-77 (1959) 
  15. Nestler, E.J., Hyman, S.E. and Malenka, R.C.: Signalling to the nucleus. pp 115-137. in Molecular neuropharmacology, McGraw-Hill, New York (2001) 
  16. Nestler, E.J.: Molecular mechanisms of drug addiction. J. Neurosci. 12, 2439-2450 (1992) 
  17. Kim, D.S., Lim, H.K., lang, S. and Oh, S.: Changes of the level of G protein -subunit mRNA by tolerance to and withdrawal from butorphanol. Neurochem. Res. 28, 1771-1778(2003) 
  18. Nagamatsu, K., Kido, Y., Terao, T., Ishida, T. and Toki, S.: Effect of morphinone on opiate receptor binding and morphine-elicited analgesia. Life Sci. 31, 1451-1457 (1982) 
  19. Nagamatsu, K., Kido, Y., Terao, T., Ishida, T. and Toki, S.: Protective effect of sulfhydryl compounds on acute toxicity of morphinone. Life Sci. 30, 1121-1127 (1982) 
  20. Oh, S., Kim, J.I., Chung, M.W. and Ho, I.K.: Modulation of NMDA receptor subunit mRNA in butorphanol-tolerant and -withdrawing rats. Neurochem. Res. 25: 1603-1611 (2000) 

이 논문을 인용한 문헌 (1)

  1. Oh, Sei-Kwan 2008. "Antinarcotic Effect of Ginseng" Journal of ginseng research = 高麗人參學會誌, 32(1): 1~7 


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