[논문]Inhibitory Action of the Ginseng Total Saponin on the Nalbuphine-Induced Tolerance and Withdrawal Syndrome

Kim, Dong-Hyun; Yoo, Hwan-Soo; Jang, Choon-Gon; Kang, Jong-Seok; Kim, Dong-Sup; Choi, Ki-Hwan; Jang, So-Yong; Oh, Sei-Kwan

doi:10.5142/jgr.2005.29.2.086

Inhibitory Action of the Ginseng Total Saponin on the Nalbuphine-Induced Tolerance and Withdrawal Syndrome 원문보기

Journal of ginseng research = 高麗人參學會誌, v.29 no.2 = no.78, 2005년, pp.86 - 93

Kim, Dong-Hyun (Graduate School of Pharmacy, Chungbuk National University) , Yoo, Hwan-Soo (Graduate School of Pharmacy, Chungbuk National University) , Jang, Choon-Gon (College of Pharmacy, Sung Kyun Kwan University) , Kang, Jong-Seok (Graduate School of Sports Science, Korea Natioanl Sports University) , Kim, Dong-Sup (Department of Pharmacology, Korea Food and Drug Administration) , Choi, Ki-Hwan (Department of Pharmacology, Korea Food and Drug Administration) , Jang, So-Yong (Department of Neuroscience, School of Medicine, Ewha University) , Oh, Sei-Kwan (Department of Neuroscience, School of Medicine, Ewha University)

Abstract ▼ AI-Helper

This study was undertaken to determine the antagonism of the ginseng total saponin (GTS) on the development of nalbuphine-induced tolerance and physical dependence. GTS is blown to have antinarcotic action with a dose of 100mg/kg (i.p.) in rats. STS significantly inhibits the development of nalbuphine-induced physical dependence as well as the tolerance. The level of pCREB was elevated in the striatum by the chronic treatment with nalbuphine or GTS, how-ever, the elevation of pCREB was inhibited by the GTS co-treatment. It has been suggested that NMDA receptor and/or NO is involved in the penomena of opioid dependence and withdrawal. However, the level of nNOS and NR1 was not modulated by the treatment with nalbuphine or GTS on the cortex, hippocampus and striatum in the rat brain. These results suggest that the GTS could be used to ameliorate the nalbuphine tolerance and withdrawal symptoms.

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가설 설정

Western blot analysis of protein levels suggests that signal transduction system was not s_이ely attributable to the nal buphine-induced withdrawal syndrome. We hypothesize that the inhibitory effects of GTS on nalbuphine-induced physical dependence and tolerance are closely related to the modulation of CREB (cyclic AMP response element binding) protein expression.

제안 방법

Additional groups of rat that had received the same nal buphine and GTS as described in the development of nal buphine tolerance were used in this experiment. The inhibition of naloxone-induced withdrawal syndrome in nalbuphine-dependent rat was estimated by the observa tion of the withdrawal syndrome by naloxone 10 mg/kg (i.
) to rat Ihr prior to the injection of nalbuphine. The test of nalbuphine analgesia was estimated at 0, 30, 60, 90 minutes for 6days by tail flick methods (n=10). The inhibitory effects of GTS on the development of nalbphine-induced tolerance were shown on day 1 (A), day 3 (B), and day 5 (C).

데이터처리

The data were expressed as mean± S.E. The differ ences in the means for different responses in different treatment groups were analyzed using ANOVA followed by the Newman-Keuls's post hoc test..

성능/효과

In our experimental results, the level of pCREB was significantly modulated by the co-treatment with nalbu phine and GTS in the striatum although the level was increased by the treatment with GTS alone. This up-regu- lation could be helpful to enhance the memory perfor mance in the hippocampus, although it is not easy to explain why this level was increased.

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