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Effects of Ginsenoside Total Saponins on Experimental Irritable Bowel Syndrome in Rats

Journal of ginseng research = 高麗人參學會誌, v.29 no.2 = no.78, 2005년, pp.94 - 99  

Kim, Jong-Hoon (Research Laboratory for the Study of Ginseng Signal Transduction and Dept. of Physiology, College of Veterinary Medicine, Konkuk University) ,  Nah, Seung-Yeol (Research Laboratory for the Study of Ginseng Signal Transduction and Dept. of Physiology, College of Veterinary Medicine, Konkuk University)

Abstract AI-Helper 아이콘AI-Helper

In the previous study, we reported that the in viかo inhibitory effect of ginsenosides, active ingredient of Panax ginseng, on $5-HT_{3A}$ receptor channel activity is coupled to in vivo anti-vomiting and anti-nausea effect. In the present study, we further investigated that the inhibitory...

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제안 방법

  • We also investigated time-dependent efifect ofPD or PT ginsenosides on CRD-induced visceral pain. After intraperitoneal injection of saline (control), PD (100 ㎎/㎏) or PT ginsenosides (100 ㎎/㎏), a second period of distension (30 mmHg for 10 min) was again applied (treatment period) 5, 10, 20, 60, 120, 240 and 480 minutes later injection, respectively. Percent antinociceptions were 11.
  • As a next step, we investigated time-course effect of (3TS on CRD-induced visceral pain. As a previous second period of distens method, after injection of saline (control), 30 ㎎/㎏ zacopride or 100 ㎎/㎏ GTS, a second period of distension (30 mmHg for 10 min) was again applied (treatment period) 5, 10, 20, 60, 120, 240 and 480 minutes later injection, respectively. Percent antinociceptions were 3.

대상 데이터

  • Ginseng total saponins (GTS) and PD and PT ginsenosides compounds were provided from the Korea Ginseng and Tobacco Research Institute (Korea). PD ginsenosides contained Rb} (34.
  • 1. Structures of the nine representative ginsenosides. They differ at three side chains attached the common steroid ring.

이론/모형

  • Results are expressed as means! S.E.M. Statistical significance between control and treatment periods was assessed using the Wilcoxon test. Differences were considered statistically significant at P< 0.
  • The antinociceptive effect of 5-HT3 receptor antagonists was expressed by the following equation: % antinociception=100 x [1-(AC after treat- ment/AC before treatment)] (AC=cumulative abdominal contraction). The ED50 was calculated using the method of Litchfield and Wilcoxon(2).
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참고문헌 (14)

  1. Camilleri, M., Northcutt, A.R., Kong, S., Dukes, G.E., McSorley, D. and Mangel, A.W. : Efficacy and safety of alosetron in women with irritable bowel syndrome: a randomised, placebo-controlled trial. Lancet. 355, 1035-1040 (2000) 

  2. Prior, A. and Read, N.W : Reduction of rectal sensitivity and post-prandial motility by granisetron, a 5- $HT_3$ -receptor antagonist, in patients with irritable bowel syndrome. Aliment. Pharmacol. Ther. 7, 175-180 (1993) 

  3. Hammer, J., Phillips, S.P., Talley, N.J. and Camilleri, M : Effect of 5- $HT_3$ -antagonist (ondansetron) on rectal sensitivity and compliance in health and the irritable bowel syndrome. Aliment. Pharmacol. Ther. 7, 543 (1993) 

  4. Talley, N.J : 5-hydroxytryptamine agonists and antagonists in the modulation of gastrointestinal motility and sensation: clinical implications. Aliment. Pharmacol. Ther. Review article 6, 273 (1992) 

  5. Abe, T : Clinical studies of the vitamins. Jpn. Soc. Inter. Med. 54, 989-1006 (1965) 

  6. Attele, A. S., Wu, J. A. and Yuan, C. S : Ginseng pharmacology: multiple constituents and multiple actions. Biochem. Pharmacol. 58, 1685- I 693 (1999) 

  7. Kudo, K., Tachikawa, E., Kashimoto, T. and Takahashi, E : Properties of ginseng saponin inhibition of catecholamine secretion in bovine chromaffin cells. Eur. J. Pharmacol. 341, 139-144 (1998) 

  8. Choi, S., Jung, S. Y., Lee, J. H., Sala, F., Criado, M., Mulet, J., Valor, L. M., Sala, S., Engel, A. G and Nah, S. Y.: Effects of ginsenosides, active components of ginseng, on nicotinic acetylcholine receptors expressed in Xenopus oocytes. Eur. J. Pharmacol. 442,37-45 (2002) 

  9. Sala, F., Mulet, J., Choi, S., Jung, S. Y., Nah, S. Y., Rhim, H., Valor, L. M., Criado, M. and Sala, S : Effects of ginsenoside Rg2 on human neuronal nicotinic acetylcholine receptors. J. Pharmacol. Exp. Ther. 301, 1052-1059 (2002) 

  10. Lee, B.H., Jeong, S.M., Lee, J.H., Kim, D.H., Kim, J.H., Kim, J.I., Shin, H.C., Lee, S.M. and Nah, S.Y : Differential effect of ginsenoside metabolites on the 5- $HT_3$ A receptor- mediated ion current in Xenopus oocytes. Mol Cells. 29, 17(1),51-56 (2004) 

  11. Langlois, A., Pascaud, X., Junien, J.L., Dahl, S.G and Riviere, P.J: Response heterogeneity of 5- $HT_3$ receptor antagonists in a rat visceral hypersensitivity model. Eur J Pharmacol. 318, 141-144 (1996) 

  12. Litchfield, J.T., and Wilcoxon, F.: A simplified method of evaluating dose-effect experiments. J Pharmacol. Exp. Ther. 96-99 (1949) 

  13. Moss, H.E. and Sanger, G.J : The effects of granisetron, lCS 205-930 and ondansetron on the visceral pain reflex induced by duodenal distension. Br. J Pharmacol. 100, 497-501 (1990) 

  14. Banner, S.E. and Sanger, G.J : Differences between 5- $HT_3$ receptor antagonists in modulation of visceral hypersensitivity. Br. J. Pharmacol. 114, 558-562 (1995) 

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