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Self-Assembled Nanoparticles of Bile Acid-Modified Glycol Chitosans and Their Applications for Cancer Therapy

Macromolecular research, v.13 no.3, 2005년, pp.167 - 175  

Kim Kwangmeyung (Biomedical Research Center, Korea Institute of Science and Technology, KIST Regional Laboratory in Advanced Medical Technology Cluster for Diagnosis & Prediction) ,  Kim Jong-Ho (Biomedical Research Center, Korea Institute of Science and Technology, KIST Regional Laboratory in Advanced Medical Technology Cluster for Diagnosis & Prediction) ,  Kim Sungwon (Biomedical Research Center, Korea Institute of Science and Technology) ,  Chung Hesson (Biomedical Research Center, Korea Institute of Science and Technology) ,  Choi Kuiwon (Biomedical Research Center, Korea Institute of Science and Technology) ,  Kwon Ick Chan (Biomedical Research Center, Korea Institute of Science and Technology, KIST Regional Laboratory in Advanced Medical Technology Cluster for Diagnosis & Prediction) ,  Park Jae Hyung (Department of Advanced Polymer and Fiber Materials, College of Environment and Applied Chemistry, Kyung Hee University) ,  Kim Yoo-Shin (Department of Biochemistry, School of Medicine, Kyungpook National University, Advanced Medical Technology Cluster for Diagnosis & Prediction) ,  Park Rang-Won (Department of Biochemistry,) ,  Kim In-San ,  Jeong Seo Young

Abstract AI-Helper 아이콘AI-Helper

This review explores recent works involving the use of the self-assembled nanoparticles of bile acid-modified glycol chitosans (BGCs) as a new drug carrier for cancer therapy. BGC nanoparticles were produced by chemically grafting different bile acids through the use of l-ethyl-3-(3-dimethylaminopro...

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  •  On the other hand, the amount of BGC nanoparticles in the liver gradually decreased over the 8 day period. From the biodistribution results, it was concluded that the BGC nano­ particles were retained for 8 days in the systemic circulation after their intravenous administration and that their enhanced biodistribution allowed them to accumulate and extravagate into the tumor tissues due to the EPR effect.
  • The variation in the hydrophobic­ity of the bile acids also affected the size of the self-aggre­ gates. It was found that the CGC derivatives with the more hydrophobic 5-^-colanic acid formed nanoparticles with a lower DS value, as compared to the DGC derivatives. Over­all, the mean sizes of the BGC nanoparticles were larger than those based on the bile acid-modified chitosan self-aggre­ gates (161-180 nm).
  • 15) at 37°C was found to be mainly dependant on the DS of deoxycholic acid (Figure 6). The results indicated that the mean size of the DGC nano­ particles increased with increasing incubation time when the DS value of deoxycholic acid was lower than 12. How­ ever, the mean diameter of the DGC nanoparticles with a higher DS of deoxycholic acid did not vary with increasing incubation time, but showed a very narrow size distribution.
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