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We investigated the effect of pycnogenol (PYC) supplementation on retarding the immune dysfunction of CS7BL/6 mice after murine AIDS (MAIDS) development. Dysfunction of T and B cell mitogenesis from primary cultured splenocytes has been observed with retrovirus infection and PYC supplementation partially recovered the dysfunction of T and B cells. There was an abnormal shift of cytokine pattern with retrovirns infection, which was designated by the decreased secretion of Th1 cytokines and increased secretion of Th2 cytokines. PYC supplementation increased IL-2 and $IFN-\gamma$ secretion and decreased IL-4, IL-6, and $TNF-\alpha$ secretion, but it was not sufficient enough to maintain the normal level of these cytokines. Hepatic vitamin E level was significantly decreased by retrovirns infection, in accordance with increased hepatic lipid peroxidation level, whereas PYC supplementation normalized the hepatic level of vitamin E and lipid peroxidation. This study suggests that PYC supplementation may partially help retard the incidence of symptoms during MAIDS.

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참고문헌 (21)

  1. Gasparis AP, Tassiopoulos AK. 2001. Nutritional support in the patient with HIV infection. Nutr 17: 981-982 
  2. Liu X, Wei J, Tan F, Zhou S, Wurthwein G, Rohdewald P. 2004. Pycnogenol, French maritime pine bark extract, improves endothelial function of hypertensive patients. Life Sci 74: 855-862 
  3. Devaraj S, Vega-Lopez S, Kaul N, Schonlau F, Rohdewald P, Jialal I. 2002. Supplementation with a pine bark extract rich in polyphenols increases plasma antioxidant capacity and alters the plasma lipoprotein profile. Lipids 37: 931-934 
  4. Veurink G, Liu D, Taddei K, Perry G, Smith MA, Robertson TA, Hone E, Groth DM, Atwood CS, Martins RN. 2003. Reduction of inclusion body pathology in ApoE-deficient mice fed a combination of antioxidants. Free Radic Biol Med 34: 1070-1077 
  5. Liang B, Jiang S, Zhang G, Inserra P, Lee J, Solkoff D, Watson RR. 2001. Anti-inflammatory effects of theophylline: modulationof immune functions during murine leukemia virus infection. Immunopharmacol Immunotoxicol 23: 307-317 
  6. Lee J, Sepulveda T, Jiang S, Inserra P, Zhang Y, Hosseini S, Watson RR. 1999. Immune dysfunction during alcohol consumption and murine AIDS: the protective role of dehydroepiandrosterone sulfate. Alcohol Clin Exp Res 23: 856-862 
  7. Chouaib S, Welte K, Mertelsmann R, Dupont T. 1985. PGE2 acts at two distinct pathways of T lymphocyte activation: inhibition of IL-2 production and down regulation of transferrin expression. J Immunol 135: 1172-1179 
  8. Ohishi N, Ohkawa H, Miike A, Tatano T, Yagi K. 1985. A new assay method for lipid peroxides using a methylene blue derivatives. Biochem Int 10: 205-211 
  9. Burton GW, Webb A, Ingold KV. 1985. A mild, rapid, and efficient method of lipid extraction for use in determining vitamin E/lipid ratio. Lipids 20: 29-39 
  10. Liu FJ, Zhang YX, Lau BH. 1998. Pycnogenol enhances immune and haemopoietic functions in senescence-accelerated mice. Cell Mol Life Sci 54: 1168-1172 
  11. Beyer RE. 1992. An analysis of the role of coenzyme Q in free radical generation and as an antioxidant. Biochem Cell Biol 70: 390-403 
  12. Kanagawa O, Vaupel BA, Gayma S, Koehler G, Kopf M. 1993. Resistance of mice deficient in IL-4 to retrovirusinduced immunodeficiency syndrome (MAIDS). Sciences 62: 240-242 
  13. Wang Y, Ardestani SK, Liang B, Bechham C, Watson RR. 1994. Anti-lL-4 monoclonal antibody and interferongamma administration retards development of immune dysfunction and cytokine dysregulation during murine AIDS. Immunol 83: 384-389 
  14. Lee J, Jiang S, Liang B, Inserra P, Zhen Z, Solkoff D, Watson RR. 1998. Antioxidant supplementation in prevention and treatment of immune dysfunction and oxidation induced by murine AIDS in old mice. Nutr Res 18: 327-339 
  15. Sepulveda T, Jiang J, Watson RR. 2002. Selenium supplementation decreases oxsackievirus heart disease during murine AIDS. Cardiovasc Toxicol 2: 53-61 
  16. Winterboum CC, Kettle AJ. 2003. Radical-radical reactions of superoxide: a potential route to toxicity. Bioehem Biophys Res Commun 305: 729-736 
  17. Kaminska T, Szuster-Cliesielska A, Wysocka A, Marmurowska-Michalowska H, Dubas-Slemp H, KandeferSzerszen M. 2003. Serum cytokine level and production of reactive oxygen species (ROS) by blood neutrophils from a schizophrenic patient with hypersensitivity to neuroleptics. Med Sci Monit 9: 71-75 
  18. Grimm T, Schafer A, Hogger P. 2004. Antioxidant activity and inhibition of matrix metallo-proteinase by metabolites of maritime pine bark extract. Free Radic Biol Med 36: 811-822 
  19. Cheshier JE, Ardestani-Kaboudanian S, Liang B, Araghiniknam M, Chung S, Lane L, Castro A, Watson RR. 1996. Immunomodulation by pycnogenol in retrovirus-infected or ethanol-fed mice. Life Sci 58: 87-96 
  20. Bito T, Roy S, Sen CK, Packer L. 2000. Pine bark extract pycnogenol downregulates IFN-gamma induced adhesion of T cells to human keratinocytes by inhibiting inducible ICAM-l expression. Free Radic Biol Med 28: 219-227 
  21. Parasad AS. 2000. Effects of zinc deficiency on Thl and Th2 cytokine shifts. J Infect Dis 182: s62-s68 

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