$\require{mediawiki-texvc}$
  • 검색어에 아래의 연산자를 사용하시면 더 정확한 검색결과를 얻을 수 있습니다.
  • 검색연산자
검색연산자 기능 검색시 예
() 우선순위가 가장 높은 연산자 예1) (나노 (기계 | machine))
공백 두 개의 검색어(식)을 모두 포함하고 있는 문서 검색 예1) (나노 기계)
예2) 나노 장영실
| 두 개의 검색어(식) 중 하나 이상 포함하고 있는 문서 검색 예1) (줄기세포 | 면역)
예2) 줄기세포 | 장영실
! NOT 이후에 있는 검색어가 포함된 문서는 제외 예1) (황금 !백금)
예2) !image
* 검색어의 *란에 0개 이상의 임의의 문자가 포함된 문서 검색 예) semi*
"" 따옴표 내의 구문과 완전히 일치하는 문서만 검색 예) "Transform and Quantization"
쳇봇 이모티콘
안녕하세요!
ScienceON 챗봇입니다.
궁금한 것은 저에게 물어봐주세요.

논문 상세정보

Abstract

We investigated the effect of pycnogenol (PYC) supplementation on retarding the immune dysfunction of CS7BL/6 mice after murine AIDS (MAIDS) development. Dysfunction of T and B cell mitogenesis from primary cultured splenocytes has been observed with retrovirus infection and PYC supplementation partially recovered the dysfunction of T and B cells. There was an abnormal shift of cytokine pattern with retrovirns infection, which was designated by the decreased secretion of Th1 cytokines and increased secretion of Th2 cytokines. PYC supplementation increased IL-2 and $IFN-\gamma$ secretion and decreased IL-4, IL-6, and $TNF-\alpha$ secretion, but it was not sufficient enough to maintain the normal level of these cytokines. Hepatic vitamin E level was significantly decreased by retrovirns infection, in accordance with increased hepatic lipid peroxidation level, whereas PYC supplementation normalized the hepatic level of vitamin E and lipid peroxidation. This study suggests that PYC supplementation may partially help retard the incidence of symptoms during MAIDS.

저자의 다른 논문

참고문헌 (21)

  1. Gasparis AP, Tassiopoulos AK. 2001. Nutritional support in the patient with HIV infection. Nutr 17: 981-982 
  2. Liu X, Wei J, Tan F, Zhou S, Wurthwein G, Rohdewald P. 2004. Pycnogenol, French maritime pine bark extract, improves endothelial function of hypertensive patients. Life Sci 74: 855-862 
  3. Devaraj S, Vega-Lopez S, Kaul N, Schonlau F, Rohdewald P, Jialal I. 2002. Supplementation with a pine bark extract rich in polyphenols increases plasma antioxidant capacity and alters the plasma lipoprotein profile. Lipids 37: 931-934 
  4. Veurink G, Liu D, Taddei K, Perry G, Smith MA, Robertson TA, Hone E, Groth DM, Atwood CS, Martins RN. 2003. Reduction of inclusion body pathology in ApoE-deficient mice fed a combination of antioxidants. Free Radic Biol Med 34: 1070-1077 
  5. Liang B, Jiang S, Zhang G, Inserra P, Lee J, Solkoff D, Watson RR. 2001. Anti-inflammatory effects of theophylline: modulationof immune functions during murine leukemia virus infection. Immunopharmacol Immunotoxicol 23: 307-317 
  6. Lee J, Sepulveda T, Jiang S, Inserra P, Zhang Y, Hosseini S, Watson RR. 1999. Immune dysfunction during alcohol consumption and murine AIDS: the protective role of dehydroepiandrosterone sulfate. Alcohol Clin Exp Res 23: 856-862 
  7. Chouaib S, Welte K, Mertelsmann R, Dupont T. 1985. PGE2 acts at two distinct pathways of T lymphocyte activation: inhibition of IL-2 production and down regulation of transferrin expression. J Immunol 135: 1172-1179 
  8. Ohishi N, Ohkawa H, Miike A, Tatano T, Yagi K. 1985. A new assay method for lipid peroxides using a methylene blue derivatives. Biochem Int 10: 205-211 
  9. Burton GW, Webb A, Ingold KV. 1985. A mild, rapid, and efficient method of lipid extraction for use in determining vitamin E/lipid ratio. Lipids 20: 29-39 
  10. Liu FJ, Zhang YX, Lau BH. 1998. Pycnogenol enhances immune and haemopoietic functions in senescence-accelerated mice. Cell Mol Life Sci 54: 1168-1172 
  11. Beyer RE. 1992. An analysis of the role of coenzyme Q in free radical generation and as an antioxidant. Biochem Cell Biol 70: 390-403 
  12. Kanagawa O, Vaupel BA, Gayma S, Koehler G, Kopf M. 1993. Resistance of mice deficient in IL-4 to retrovirusinduced immunodeficiency syndrome (MAIDS). Sciences 62: 240-242 
  13. Wang Y, Ardestani SK, Liang B, Bechham C, Watson RR. 1994. Anti-lL-4 monoclonal antibody and interferongamma administration retards development of immune dysfunction and cytokine dysregulation during murine AIDS. Immunol 83: 384-389 
  14. Lee J, Jiang S, Liang B, Inserra P, Zhen Z, Solkoff D, Watson RR. 1998. Antioxidant supplementation in prevention and treatment of immune dysfunction and oxidation induced by murine AIDS in old mice. Nutr Res 18: 327-339 
  15. Sepulveda T, Jiang J, Watson RR. 2002. Selenium supplementation decreases oxsackievirus heart disease during murine AIDS. Cardiovasc Toxicol 2: 53-61 
  16. Winterboum CC, Kettle AJ. 2003. Radical-radical reactions of superoxide: a potential route to toxicity. Bioehem Biophys Res Commun 305: 729-736 
  17. Kaminska T, Szuster-Cliesielska A, Wysocka A, Marmurowska-Michalowska H, Dubas-Slemp H, KandeferSzerszen M. 2003. Serum cytokine level and production of reactive oxygen species (ROS) by blood neutrophils from a schizophrenic patient with hypersensitivity to neuroleptics. Med Sci Monit 9: 71-75 
  18. Grimm T, Schafer A, Hogger P. 2004. Antioxidant activity and inhibition of matrix metallo-proteinase by metabolites of maritime pine bark extract. Free Radic Biol Med 36: 811-822 
  19. Cheshier JE, Ardestani-Kaboudanian S, Liang B, Araghiniknam M, Chung S, Lane L, Castro A, Watson RR. 1996. Immunomodulation by pycnogenol in retrovirus-infected or ethanol-fed mice. Life Sci 58: 87-96 
  20. Bito T, Roy S, Sen CK, Packer L. 2000. Pine bark extract pycnogenol downregulates IFN-gamma induced adhesion of T cells to human keratinocytes by inhibiting inducible ICAM-l expression. Free Radic Biol Med 28: 219-227 
  21. Parasad AS. 2000. Effects of zinc deficiency on Thl and Th2 cytokine shifts. J Infect Dis 182: s62-s68 

이 논문을 인용한 문헌 (0)

  1. 이 논문을 인용한 문헌 없음

원문보기

원문 PDF 다운로드

  • ScienceON :

원문 URL 링크

원문 PDF 파일 및 링크정보가 존재하지 않을 경우 KISTI DDS 시스템에서 제공하는 원문복사서비스를 사용할 수 있습니다. (원문복사서비스 안내 바로 가기)

상세조회 0건 원문조회 0건

DOI 인용 스타일