$\require{mediawiki-texvc}$
  • 검색어에 아래의 연산자를 사용하시면 더 정확한 검색결과를 얻을 수 있습니다.
  • 검색연산자
검색연산자 기능 검색시 예
() 우선순위가 가장 높은 연산자 예1) (나노 (기계 | machine))
공백 두 개의 검색어(식)을 모두 포함하고 있는 문서 검색 예1) (나노 기계)
예2) 나노 장영실
| 두 개의 검색어(식) 중 하나 이상 포함하고 있는 문서 검색 예1) (줄기세포 | 면역)
예2) 줄기세포 | 장영실
! NOT 이후에 있는 검색어가 포함된 문서는 제외 예1) (황금 !백금)
예2) !image
* 검색어의 *란에 0개 이상의 임의의 문자가 포함된 문서 검색 예) semi*
"" 따옴표 내의 구문과 완전히 일치하는 문서만 검색 예) "Transform and Quantization"
쳇봇 이모티콘
안녕하세요!
ScienceON 챗봇입니다.
궁금한 것은 저에게 물어봐주세요.

논문 상세정보

Abstract

We examined whether the abnormal EEG state by NMDA receptor blocker MK-801 can be reversed by typical and atypical antipsychotics differentially by comparing their spectral profiles after drug treatment in rats. The spectral profiles produced by typical antipsychotics chlorpromazine (5 mg/kg, i.p.) and haloperidol (0.5 mg/kg, i.p.) were differ from that by atypical antipsychotic clozapine (5 mg/kg, i.p.) in the rats treated with or without MK-801 treatment (0.2 mg/kg, i.p.) which produce behavioral abnormalities like hyperlocomotion and stereotypy. The dissimilarity between the states produced by antipsychotics and the control state was examined with the distance of the location of the canonical variables calculated by stepwise discriminant analysis with the relative band powers as input variables. Although clozapine produced more different state from normal state than typical antipsychotics, clozapine could reverse the abnormal schizophrenic state induced by MK-801 to the state closer to the normal state than the typical antipsychotics. The results suggest that atypical anesthetic can reverse the abnormal schizophrenic state with negative symptom to the normal state better than typical antipsychotic. The results indicate that the multivariate discriminant analysis using the spectral parameters can help differentiate the antipsychotics with different actions.

참고문헌 (28)

  1. Ahnaou A, Megens AA, Drinkenburg WH. The atypical antipsychotics risperidone, clozapine and olanzapine differ regarding their sedative potency in rats. Neuropsychobiology 48: 47-54, 2003 
  2. Corbett R, Camacho F, Woods AT, Kerman LL, Fishkin RJ, Brooks K, Dunn RW. Antipsychotic agents antagonize non-competitive N-methyl-D-aspartate antagonist-induced behaviors. Psychopharmacology (Berl) 120: 67-74, 1995 
  3. Deutsch SI, Rosse RB, Billingslea EN, Bellack AS, Mastropaolo J. Topiramate antagonizes MK-801 in an animal model of schizophrenia. Eur J Pharmacol 449: 121-125, 2002 
  4. Goudie AJ, Smith JA. Discriminative stimulus properties of antipsychotics. Pharmacol Biochem Behav 64: 193-201, 1999 
  5. Koek W, Woods JH, Winger GD. MK-801, a proposed noncompetitive antagonist of excitatory amino acid neurotransmission, produces phencyclidine-like behavioral effects in pigeons, rats and rhesus monkeys. J Pharmacol Exp Ther 245: 969-974, 1988 
  6. Martin P, Waters N, Carlsson A, Carlsson ML. The apparent antipsychotic action of the 5-HT2a receptor antagonist M100907 in a mouse model of schizophrenia is counteracted by ritanserin. (Rapid communication). J Neural Transm 104: 561-564, 1997 
  7. McClelland GR, Cooper SM, Pilgrim AJ. A comparison of the central nervous system effects of haloperidol, chlorpromazine and sulpiride in normal volunteers. Br J Clin Pharmacol 30: 795-803, 1990 
  8. Seeman P, Corbett R, Van Tol HH. Atypical neuroleptics have low affinity for dopamine D2 receptors or are selective for D4 receptors. Neuropsychopharmacology 16: 93-110; discussion 111- 135, 1997 
  9. Dimpfel W, Decker H. Classification of sulpiride, clozapine and haloperidol by toposelective recording from different brain structures in the immobilized rat (stereo-EEG). Neuropsychobiology 14: 157-164, 1985 
  10. Hughes AM, Lynch P, Rhodes J, Ervine CM, Yates RA. Electroencephalographic and psychomotor effects of chlorpromazine and risperidone relative to placebo in normal healthy volunteers. Br J Clin Pharmacol 48: 323-330, 1999 
  11. Dimpfel W. Preclinical data base of pharmaco-specific rat EEG fingerprints (tele-stereo-EEG). Eur J Med Res 8: 199-207, 2003 
  12. Yun JE, Lee MG. Electroencephalographic effects of chlorpromazine in rats. Kor J Physiol Pharmacol 3: 245-250, 1999 
  13. Varty GB, Higgins GA. Examination of drug-induced and isolationinduced disruptions of prepulse inhibition as models to screen antipsychotic drugs. Psychopharmacology (Berl) 122: 15-26, 1995 
  14. Arvanov VL, Wang RY. Clozapine, but not haloperidol, prevents the functional hyperactivity of N-methyl-D-aspartate receptors in rat cortical neurons induced by subchronic administration of phencyclidine. J Pharmacol Exp Ther 289: 1000-1006, 1999 
  15. Dimpfel W, Otten U. Studies of gangliosides in diverse nerve cell cultures. Adv Exp Med Biol 174: 525-534, 1984 
  16. Dimpfel W, Spuler M, Wessel K. Different neuroleptics show common dose and time dependent effects in quantitative field potential analysis in freely moving rats. Psychopharmacology (Berl) 107: 195-202, 1992 
  17. Zhang W, Pouzet B, Jongen-Relo AL, Weiner I, Feldon J. Disruption of prepulse inhibition following N-methyl-D-aspartate infusion into the ventral hippocampus is antagonized by clozapine but not by haloperidol: a possible model for the screening of atypical antipsychotics. Neuroreport 10: 2533-2538, 1999 
  18. Sams-Dodd F. Phencyclidine in the social interaction test: an animal model of schizophrenia with face and predictive validity. Rev Neurosci 10: 59-90, 1999 
  19. Ninan I, Kulkarni SK. Preferential blockade by clozapine of hyperlocomotion induced by non-competitive NMDA antagonist MK-801. Indian J Physiol Pharmacol 42: 375-382, 1998 
  20. Javitt DC, Zukin SR. Recent advances in the phencyclidine model of schizophrenia. Am J Psychiatry 148: 1301-1308, 1991 
  21. Smith JA, Boyer-Millar C, Goudie AJ. Does MK-801 discrimination constitute an animal model of schizophrenia useful for detecting atypical antipsychotics? Pharmacol Biochem Behav 64: 429- 433, 1999 
  22. Bo P, Ongini E, Giorgetti A, Savoldi F. Synchronization of the EEG and sedation induced by neuroleptics depend upon blockade of both D1 and D2 dopamine receptors. Neuropharmacology 27: 799-805, 1988 
  23. Arvanov VL, Liang X, Schwartz J, Grossman S, Wang RY. Clozapine and haloperidol modulate N-methyl-D-aspartate- and non-N-methyl-D-aspartate receptor-mediated neurotransmission in rat prefrontal cortical neurons in vitro. J Pharmacol Exp Ther 283: 226-234, 1997 
  24. Herrmann WM. Electroencephalography in drug research: Gustav Fischer Verlag, 1982 
  25. Hollister LE. Antipsychotic agents and lithium. In: Katzung BG ed, Basic and Clinical Pharmacology. 6th ed. Prentice Hall International, London, p 432-447, 1995 
  26. Knott V, Labelle A, Jones B, Mahoney C. Quantitative EEG in schizophrenia and in response to acute and chronic clozapine treatment. Schizophr Res 50: 41-53, 2001 
  27. Tiedtke PI, Bischoff C, Schmidt WJ. MK-801-induced stereotypy and its antagonism by neuroleptic drugs. J Neural Transm Gen Sect 81: 173-182, 1990 
  28. Lim SH, Kwon JS, Kim KM, Park SJ, Park JS, Jeong SH, Lee MG. Basic requirements for spectrum analysis of electroencephalographic effects of central acting drugs. J Appl Pharmacol 8: 63-71, 2000 

이 논문을 인용한 문헌 (1)

  1. 2009. "" The Korean journal of physiology & pharmacology : official journal of the Korean Physiological Society and the Korean Society of Pharmacology, 13(3): 147~151 

원문보기

원문 PDF 다운로드

  • ScienceON :

원문 URL 링크

원문 PDF 파일 및 링크정보가 존재하지 않을 경우 KISTI DDS 시스템에서 제공하는 원문복사서비스를 사용할 수 있습니다. (원문복사서비스 안내 바로 가기)

상세조회 0건 원문조회 0건

DOI 인용 스타일