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Morphine-induced Modulation of Nociceptive Spinal Dorsal Horn Neuronal Activities after Formalin-induced Inflammatory Pain

The Korean journal of physiology & pharmacology : official journal of the Korean Physiological Society and the Korean Society of Pharmacology, v.9 no.2, 2005년, pp.77 - 86  

Park, Joo-Min (Department of Physiology, Seoul National University College of Medicine) ,  Li, Kang-Wu (Department of Physiology, Seoul National University College of Medicine) ,  Jung, Sung-Jin (Department of Physiology, Kangwon National University College of Medicine) ,  Kim, Jun (Department of Physiology, Seoul National University College of Medicine) ,  Kim, Sang-Jeong (Department of Physiology,Xenotransplantation Research Center, Seoul National University College of Medicine)

Abstract AI-Helper 아이콘AI-Helper

In this study, we examined the morphine-induced modulation of the nociceptive spinal dorsal horn neuronal activities before and after formalin-induced inflammatory pain. Intradermal injection of formalin induced time-dependent changes in the spontaneous activity of nociceptive dorsal horn neurons. I...

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참고문헌 (39)

  1. Akaishi T, Saito H, Ito Y, Ishige K, Ikegaya Y. Morphine augments excitatory synaptic transmission in the dentate gyrus through GABAergic disinhibition. Neurosci Res 38: 357 - 363, 2000 

  2. Besson JM, Chaouch A. Peripheral and spinal mechanism of nociception. Physiol Rev 67: 67 -185, 1987 

  3. Belcher G, Ryall RW. Differential excitatory and inhibitory effects of opiates on non-nociceptive and nociceptive neurons in the spinal cord of the cat. Brain Res 145: 303-314, 1978 Campbell IN, Meyer RA, LaMotte RH. Sensitization of myelinated nociceptive afferents that innervate monkey hand. J Neurophysiol 42: 1669 -1679, 1979 

  4. Campbell IN, Meyer RA, LaMotte RH. Sensitization of myelinated nociceptive afferents that innervate monkey hand. J Neurophysiol 42: 1669 -1679, 1979 

  5. Carlton SM, Westlund KN, Zhang D, Willis WD. GABA- immunoreactive terminals synapse on primate spinothalamic tract cells. J Comp Neurol 322: 528-537, 1992 

  6. Castro-Lopes JM, Tavares I, Tolle TR, Coimbra A. Carrageenaninduced inflammation of the hind foot provokes a rise of GABAimmunoreactive cells in the rat spinal cord that is prevented by peripheral neurectomy or neonatal capsaicin treatment. Pain 56: 193 - 201, 1994 

  7. Castro-Lopes JM, Malcangio M, Pan BH, Bowery NG. Complex changes of GABAA and GABAs receptor binding in the spinal cord dorsal horn following peripheral inflammation or neurectomy. Brain Res 679: 289 - 297, 1995 

  8. Celerier E, Laulin J, Larcher A, Le Moal M, Simonnet G. Evidence for opiate-activated NMDA processes masking opiate analgesia in rats. Brain Res 847: 18-25, 1999 

  9. Chung JM, Surmeier DJ, Lee KH, Sorkin LS, Honda CN, Tsong Y, Willis WD. Classification of primate spinothalamic and somatosensory thalamic neurons based on cluster analysis. J Neurophysiol 56: 308 - 327, 1986 

  10. Dostrovsky JO, Pomeranz B. Interaction of iontophoretically ap?plied morphine with response of interneurons in cat spinal cord. Exp Neurol 52: 325 - 338, 1976 

  11. Dickenson AH, Sullivan AF. Subcutaneous formalin-induced activity of dorsal horn neurons in the rat: different response to an intrathecal opiate administered pre or post formalin. Pain 30: 349 - 360, 1987 

  12. Hammond DL, Wang H, Nakashima N, Basbaum Al. Differential effects of intrathecally administered delta and mu opioid receptor agonists on formalin-evoked nociception and on the expression of Fos-like immunoreactivity in the spinal cord of the rat. J Pharmacol Exp Ther 284: 378-387, 1998 

  13. Hylden JLK, Nahin RL, Traub RJ, Dubner R. Effects of spinal kappa-opioid receptor agonists on the responsiveness of nociceptive superficial dorsal horn neurons. Pain 44: 187 -193, 1991 

  14. Inturrisi CE. Clinical pharmacology of opioids for pain. Clin J Pain 18: S3-S13, 2002 

  15. Jones SL, Sedivec MJ, Light AR. Effects of iontophoresed opioids on physiologically characterized laminae I and II dorsal horn neurons in the cat spinal cord. Brain Res 532: 160-174, 1990 

  16. Kalyuzhny AE, Wessendorf MW. Relationship of mu- and deltaopioid receptors to GABAergic neurons in the central nervous system, including antinociceptive brainstem circuits. J Comp Neurol 392: 528- 547, 1998 

  17. Kayser V, Guilbaud G. Differential effects of various doses of morphine and naloxone on two nociceptive test thresholds in arthritic and normal rats. Pain 41: 353 - 363, 1990 

  18. Kayser V, Chen YL, Guilbaud G. Behavioural evidence for a peripheral component in the enhanced antinociceptive effect of a low dose of systemic morphine in carrageenan-induced hyperalgesic rats. Brain Res 560: 237 - 244, 1991 

  19. Kemp T, Spike RC, Watt C, Todd AJ. The mu-opioid receptor (MOR1) is mainly restricted to neurons that do not contain GABA or glycine in the superficial dorsal horn of the rat spinal cord. Neurosci 74: 1231-1238, 1996 

  20. Knox RJ, Dickenson AH. Effects of selective and non-selective -opioid receptor agonists on cutaneous C-fibre-evoked responses of rat dorsal horn neurons. Brain Res 415: 21- 29, 1987 

  21. LaMotte RH, Thalhammer JG, Robinson CJ. Peripheral neural correlates of magnitude of cutaneous pain and hyperalgesia: a comparison of neural events in monkey with sensory judgments in human. J Neurophysiol 50: 126, 1983 

  22. Lin Q, Peng YB, Willis WD. Role of GABA receptor subtype in inhibition of primate spinothalamic tract neurons: Difference between spinal and periaqueductal gray inhibition. J Neurophysiol 76: 1005 -1014, 1996 

  23. Lin Y, Carpenter DO. Direct excitatory opiate effects mediated by non-synaptic actions on rat medial vestibular neurons. Eur J Pharmacol 262: 99 -106, 1994 

  24. Mascias P, Scheede M, Bloms-Funke P, Chizh B. Modulation of spinal nociception by GluR5 kainate receptor ligands in acute and hyperalgesic states and the role of gabaergic mechanisms. Neuropharmacology 42: 327 - 339, 2002 

  25. Magnuson DS, Dickenson AH. Lamina-specific effects of morphine and naloxone in dorsal horn of rat spinal cord in vitro. J Neurophysiol 66: 1941-1950, 1991 

  26. Melzack R, Wall PD. Pain mechanism, a new theory. Science 150: 971- 979, 1965 

  27. Moran TD, Smith PA. Morphine-3beta-D-glucuronide suppresses inhibitory synaptic transmission in rat substantia gelatinosa. J Pharmacol Exp Ther 302: 568 - 576, 2002 

  28. Neil A, Kayser V, Gacel G, Besson JM, Guilbaud G. Opioid receptor types and antinociceptive activity in chronic inflammation: both kappa- and mu-opiate agonistic effects are enhanced in arthritic rats. Eur J Pharmacol 130: 203 - 208, 1986 

  29. Neumaier JF, Mailheau S, Chavkin C. Opioid receptor-mediated responses in the dentate gyrus and CAl region of the rat hippocampus. J Pharmacol Exp Ther 244: 564 - 570, 1988 

  30. North RA. Opioid receptor types and membrane ion channel. Trends Neurosci 9: 114-117, 1986 

  31. Piercey MF, Einspahr FJ, Dobry PJ, Schroeder LA, Hollister RP. Morphine does not antagonize the substance P mediated excita?tion of dorsal horn neurons. Brain Res 186: 421- 434, 1980 

  32. Reeve AJ, Dickenson AH, Kerr NC. Spinal effects of bicuculline: Modulation of an allodynia-like state by an A'l-receptor agonist, morphine, and an NMDA-receptor antagonist. J Neurophysiol 79: 1494-1507, 1988 

  33. Rivat C, Laulin JP, Corcuff JB, Celerier E, Pain L, Simonnet G. Fentanyl enhancement of carrageenan-induced long-lasting hyperalgesia in rats: prevention by the N-methyl-D-aspartate receptor antagonist ketamine. Anesthesiology 96: 381- 391, 2002 

  34. Suarez-Roca H, Maixner W. Activation of kappa opioid receptors by U50488H and morphine enhances the release of substance P from rat trigeminal nucleus slices. J Pharmacal Exp Ther 264: 648-653, 1993 

  35. Suarez-Roca H, Maixner W. Morphine produces a biphasic modulation of substance P release from cultured dorsal root ganglion neuroits. Neurosci Lett 194: 41- 44, 1995 

  36. Tan-No K, Esashi A, Nakagawasai 0, Niijima F, Tadano T, Sakurada C, Sakurada T, Bakalkin G, Terenius L, Kisara K. Intrathecally administered big dynorphin, a prodynorphinderived peptide, produces nociceptive behavior through an Nmethyl-D-aspartate receptor mechanism. Brain Res 952: 7 -14, 2002 

  37. Tjolsen A, Berge O-G, Hunskaar S, Rosland AH, Hole K. The formalin test: an evaluation of the method. Pain 51: 5 -17, 1992 

  38. Trevino DL, Coulter JD, Willis WD. Location of cells of origin of spinothalamic tract in lumbar enlargement of the monkey. J Neurophysiol 36: 750-761, 1973 

  39. Zieglgansberger W, French ED, Siggins GR, Bloom FE. Opioid peptides may excite hippocampal pyramidal neurons by inhibiting adjacent inhibitory interneurons. Science 205: 415-417, 1979 

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