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성능/효과
- , 2000). The results showed that asperuloside (9) and derivative of kaempferol-3-O-[2"-O-(E-6"'-(?-feruloyl)-p-D-glucopy- ranosyl]-p-D-galactopyranoside (26) possessed minor anti-lipid peroxidation effects, while other compounds did not. These results demonstrated that the antioxidant effects of H.
- , 1997). Results showed that 125 g/L H. diffusa could inhibit the damage to DNA in lymphocytes caused by the total particle material (TPM) extract from cigarette tar.
- 43 ng/ml) by enzyme-linked immunosorbent assay. The results demonstrated that O. diffusa increased the production of NO and TNF-a by rEMF-^primed macrophages and suggested that NF-kB played a critical role in mediating these effects of O. diffusa.
- diffusa was evaluated by assessing serum glutamate oxalate transaminase (sGOT) and serum glutamate pyruvate transaminase (sGPT) activities in experimental animals. The results indicated that H. diffusa significantly reduced the acute elevation of sGOT and sGPT concentration, and alleviated the degree of liver damage 24 hours after the intraperitoneal administration of the hepatotoxins.
- , 2003). The results of antioxidative measurement using the FTC method showed that quercetin 3-O-P-rutinoside (36) was a stronger antioxidant than quercetin 3-C시3-ghicoside (28) and a- tocopherol while asperuloside (9) was found to be inactive. The activity measured using the DPPH technique showed that 36 and 28 were slightly less active than vitamin C and a-tocopherol as radical scanvengers.
- , 2000). The results provided the evidences that expression of cell cycle related genes in HL-60 cells ungoing apoptosis by the methanol extract of H. diffusa mainly resulted from a decreased level of p21/ Cipl and an increased level of p27/Kipl of the cell cycle related genes. At the same time, the effects of aqueous and methanol extracts of H.
- , 1998) were performed to investigate the inhibitory effect of a methanol extract of Oldenlandia diffusa (OD) on the proliferation and differentiation of human cancer cell line U937. The results showed that the conditioned medium from OD-stimulated blood mononuclear cells (OD-MNC-CM) treatment induced about 50% of the cells differentiating into mature monocytes/ macrophages of CD 11b, CD 14, and CD 68. The levels of interferon (IFN)-y, tumor necrosis factor (TNF)-a, and interleukin (IL)-l were very low in normal MNC-CM, and they were greatly increased in MNC-CM prepared with OD stimulation.
- , 2000) in a human lymphoid leukemia cell line (HL-60). The results showed that the death of HL-60 cells was markedly induced by the addition of the methanol extract of H. diffusa in a dose and time-dependent manner The activity of caspase 3-like proteases remained in a basal level in HL-60 cells treated with an aqueous extract of H. diffusa. However, it was markedly increased in HL-60 cells treated with a methanol extract of H.
- Bioactivity-guided isolation was further performed to yield four known acylated iridoid glycosides, Z-6-O-p-methoxycinnamoyl scandoside methyl ester (11), E-6-O-p-feruloyl scandoside methyl ester (12), E-6-O-/?-coumaroyl scandoside methyl ester (14) Z-6-O-p- coumaroyl scandoside methyl ester (15) as well as five flavonoid glycosides kaempferol-3- O-[2-O-(6-O-E-feruloyl)-p-D-glucopyranosyl]-P-D-ga- lactopyranoside (31), quercetin-3-0-[2-6>-(6-O-E-feruloyl)- P-D-glucopyranosyl]-P-D-galactopyranoside (32), quercetin- 3-6>-[2-O-(6-€>-E-feruloyl)-P-D-glucopyranosyl]-P-D-gl- ucopyranoside (33), kaempferol-3-O-(2-O-P-D-glucop- yranosyl)-P-D-galactopyranoside (34), quercetin-3-O-(2- (9-P-D-glucopyranosyl)-P-D-galactopyranoside (35). The results suggested that all nine compounds exhibited significant neuroprotective activity in primary cultures of rat cortical cells damaged by L-glutamate.
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