• 검색어에 아래의 연산자를 사용하시면 더 정확한 검색결과를 얻을 수 있습니다.
  • 검색연산자
검색연산자 기능 검색시 예
() 우선순위가 가장 높은 연산자 예1) (나노 (기계 | machine))
공백 두 개의 검색어(식)을 모두 포함하고 있는 문서 검색 예1) (나노 기계)
예2) 나노 장영실
| 두 개의 검색어(식) 중 하나 이상 포함하고 있는 문서 검색 예1) (줄기세포 | 면역)
예2) 줄기세포 | 장영실
! NOT 이후에 있는 검색어가 포함된 문서는 제외 예1) (황금 !백금)
예2) !image
* 검색어의 *란에 0개 이상의 임의의 문자가 포함된 문서 검색 예) semi*
"" 따옴표 내의 구문과 완전히 일치하는 문서만 검색 예) "Transform and Quantization"
쳇봇 이모티콘
ScienceON 챗봇입니다.
궁금한 것은 저에게 물어봐주세요.

논문 상세정보


The chemical constituents from Hedyotis diffusa Willd and their pharmacological activities were summarized. It has been known data that this herb contains anthraquinones, terpenoids, steroids, flavonoids, organic acid, and polysaccharides. The studies of pharmacology have shown that Hedyotis diffusa Willd possess various levels of activities such as anticancer, anti-inflammatory, immunostimulatory, antioxidative, neuroprotective, and hepatoprotective activities.

참고문헌 (49)

  1. Ahmad, S.H., Norio, A., and Nordin, H.J.L., Constituents of Hedyotis herbacea (Rubiaceae). Biochem. System. Ecol. 24(3), 273 (1996) 
  2. Cai, C.L, Qian, X.L., and Jiang, D.H., Chemical investigation of Oldenlandia diffua (Willd.) Roxb. I. Yao Xue Xue Bao. (Chinese), 11, 809-814 (1964) 
  3. Chung, H.S., Jeong, H.J., Hong, S.H., Kim, M.S., Kim, S.J., Song, B.K, Jeong, I.S., Lee, E.J., Aha, J.w., Baek, S.H., and Kim, H.M., Induction of nitric oxide synthase by Oldenlandia difusa in mouse peritoneal macrophages. Biol. Pharm. Bull. 25,1142-1146 (2002) 
  4. Kim, S.H., Ann, B.Z., and Ryu, S.Y, Antitumor effects of ursolic acid isolated from Oldenlandia dijfusa. Phytother. Res. 12, 553-556 (1998) 
  5. Kim, S.H., Song, GoY, Ryu, S.Y, Antitumor and antimetastatic activities of ursolic acid and asperuloside. Korean J. Oriental Medical Pathology 13, 65-75 (1999) 
  6. Lin, C.C., Chen, J.Y, and Namba, T., Development of natural crude drug resources from Taiwan (V): Pharmacognostical studies on Chinese crude drug 'Peh-hue-juwa-chi-cao', Shoyakugaku Zasshi 41, 180-188 (1987) 
  7. No, H.J., Moon, G., Moon, S.J., Won, J.H., Moon, Y.H., and Park, R.G., Study on Hedyotis diffusa methanol extract on antitumor effect and mechanism. J. of Kor. Oriental Oncology 6, 81-97 (2000) 
  8. Wong, B.Y., Lau, B,H., Jia, T.Y., and Wan, C.P., Oldenlandia diffusa and Scutellaria barbata augment macrophage oxidative burst and inhibit tumor growth. Cancer Biother. Radiopharm. 11,51-56 (1996) 
  9. Wu, H., Tao, X., Chen, Q., and Lao, X., Iridoids from Hedyotis diffusa. J. Nat. Prod. 54, 254 (1991) 
  10. Yang, J.J., Hsu, H.Y., Ho, Y.H., and Lin, e.e., Comparative study on the immunocompetent activity of three different kinds of Peh-Hue-Juwa-Chi-Cao, Hedyotis diffusa, H. corymbosa and Mollugo pentaphylla after sublethal whole body X-irradiation. Phytother. Res. 11, 428-437 (1997b) 
  11. Hsu, H.Y., Tumor inhibition by several components extracted from Hedyotis corymbosa and Hedyotis difusa. Cancer Detect. Preven. 22 (Supplement 1), (1998) 
  12. Lin, C.C., Ng, L.T., Yang, J.J., and Hsu, Y.F, Anti-inflammatory and hepatoprotective activity of Peh-Hue-Juwa-Chi-Cao in male rats. Am. J. Chin. Med. 30, 225-234 (2002) 
  13. Lv, H.C., and He, J., Study on chemical components of Hedyotis diffusa Willd. Natural Product R&D. (Chinese), 18, 3437(1996) 
  14. Tai, D.E, Lin, Y.M., and Chen, Ee., Components of Hedyotis diffusa Willd. Chemistry (Taipei), 3, 60-61 (1979) 
  15. Wong, K.C; and Tan, G.L., Composition of the essential oil of Hedyotis diffusa Willd. J. Essent. Oil Res. 17, 537-539 (1995) 
  16. Wong, B.Y., Lau, B.H., Yamasaki, T., and Teel, RW, Inhibition of dexamethasone-induced cytochrome P450-mediated mutagenicity and metabolism of aflatoxin B1 by Chinese medicinal herbs. Eur. J. Cancer Prev. 2, 351-356 (1993a) 
  17. Kim, YH., Studies on the constituents of Oldenlandia diffusa. Korean J. Medicinal Crop Sci. 3(2),91-95 (1995) 
  18. Takagi, S., Yamaki, M., Nishihama, Y., and Ishiguro, K, On the iridoid glycosides of the Chinese drug 'bai hua she she cao' (Hedyotis diffusa Willd.). Shyoyakugaku Zasshi 36, 366-399 (1982) 
  19. Yang, T.H., Chen, K.T., and Chen, C.H., Constituents of Formosan Hedyotis diffusa. Taiwan Yao Hsueh Tsa Chih. 23, 4-7 (1971) 
  20. Ho, T.I., Chen, G.P., Lin, vc., Lin, Y.M., and Chen, nc, An anthraquinone from Hedyotis difusa. Phytochemistry 25, 1988-1989 (1986) 
  21. Dharma, P., Nordin, H.L., Faridah, A, Othman, A.G., Rohaya, A., Mariko, K, Takayama, H., and Norio, A, Antioxidative constituents of Hedyotis difusa Willd. Nat. Prod. Sci. 9, 7-9 (2003) 
  22. Han, F., Hu, J., and Xu, H., Effects of some Chinese herbal medicine and green tea antagonizing mutagenesis caused by cigarette tar. Zhonghua Yu Fang Yi Xue Za Zhi. (Chinese),31, 71-74 (1997) 
  23. Liao, L.L., Chen, C.H., and Chen, G.C, Formosan medicinal herb, Hedyotis diffusa Willd., as an antitumor agent. Taiwan Yi Xue Hui Za Zhi. 78, 658-660 (1979) 
  24. Fu, Y.F., Xu, Z.P., and Li, M.D., Study on chemical components of Hedyotis difusa Willd. Yao Xue Xue Bao. (Chinese), 10, 618-621 (1963) 
  25. Shan, B.E., Zhang, J.Y., Du, X.N., Immunomodulatory activity and anti-tumor activity of Oldenlandia diffusa in vitro. Zhongguo Zhong Xi Yi lie He Za Zhi. (Chinese), 21, 370-374 (2001) 
  26. Yoshida, Y., Wang, M.Q., and Liu, I.N., Immunomodulation activity of Chinese medicinal herbs and Oldenlandia diffusa in particular. Int. J Immunopharmacol. 19, 359-370 (1997) 
  27. Zhong, L.M., Zhou, HX, and Liu, D., The pharmacological and clinical research development of Baihuasheshecao (Herba Oldenlandia Difusae). Information on Traditional Chinese Medicine. (Chinese), 18, 14-15 (2001) 
  28. Pak, S.G., Lee, J.H., Moon, G., Moon, S.J., Won, J.H., and Pak, L.G., Study on transcriptional factors activation change of HL-60 cell apoptosis by Hedyotis diffusas methanol extract. J. of Kor. Oriental Oncology 6, 67-79 (2000) 
  29. Wu, Q., Clinical application of Hedyotis diffusa. Zhong Yao Cai. (Chinese), 23, 654-657(2000) 
  30. Hsu, H.Y., Yang, J.J., and Lin, C.C., Effects of oleano1ic acid and ursolic acid on inhibiting tumor growth and enhancing the recovery of hematopoietic system postirradiation in mice. Cancer Lett. 111,7-13 (1997) 
  31. Wu, H.M, Huang, S.Y., Lao, X.F, Ma, K, and Zhou, H.Q., A study on the structure of the polysaccharide from Hedyotis diffusa Willd. Chinese Journal of Organic Chemistry (Chinese), 12,428-431 (1992) 
  32. Gupta, S., Zhang, D., Yi, J., and Shao, J., Anticancer activities of Oldenlandia difusa. J. Herb Pharmacother. 4, 21-33 (2004) 
  33. Nishihawa, Y, Masuda, K., Yamaki, M., Takagi, S., and Sakina, K., Three new iridoid glycosides from Hedyotis diffusa. Planta Medica. 43,28-33 (1981) 
  34. Qin, EH., Xie, S.S., Zhang, WR, and Long, Z.Z., The enhancing effect of Hedyotis diffusa Willd on immunological function of mice. Shanghai Mian yi Xue Za zhi. (Chinese), 10, 321-323 (1990) 
  35. Wong, B.Y., Lau, B.H., Tadi, P.P., and Teel, RW, Chinese medicinal herbs modulate mutasgenesis, DNA binding and metabolism of aflatoxin B1. Mutat. Res. 279, 209-216 (1992a) 
  36. Dharma, P., Nordin, H.L., Othman, AG., Abdul, M.A., Norio, A, Mariko, K, and Takayama, H., Anthraquinones from Hedyotis herbacea. J. Nat. Prod. 62, 1430-1431 (1999) 
  37. Lin, C.C., Ng, L.T., and Yang, J.J., Antioxidant activity of extracts of peh-hua-juwa-chi-cao in a cell free system. Am. J. Chin. Med. 32, 339-349 (2004) 
  38. Yang, J.J., Hsu, H.Y., and Lin, C.C., The possibility to use PehHue-Juwa-Chi-Cao as an antitumor agent and radioprotector after therapeutic irradiation. Phytother. Res. 11, 6-10 (1997a) 
  39. Wong, B,Y., Lau, B.H., and Teel, R.W, Chinese medicinal herbs modulate mutasgenesis, DNA binding and metabolism of benzo[a]pyrene 7, 8-dihydrodiol and benzo[a]pyrene 7,8-dihydrodiol-9, 10-epoxide. Cancer Lett. 62, 123-131 (1992b). 
  40. Wong, B.Y., Lau, B.H., Yamasaki, T., and Teel, RW, Modulation of cytochrome P-450IA1-mediated mutagenicity, DNA binding and metabolism of benzo[a]pyrene by Chinese medicinal herbs. Cancer Lett. 63, 75-82 (1993b). 
  41. Kim, S.H., Antitumor and inhibitory of topoisomerase-I by ursonic acid. Korean J. Oriental Medical Pathology 11, 12-15 (1997) 
  42. Cai, C.L., Qian, X.L., and Jiang, D.H., Study on chemical components of Hedyotis diffuusa Willd. II. Yao Xue Xue Bao. (Chinese), 13, 181 (1966) 
  43. Shan, B.E., Yoshida, Y., Sugiura, T., and Yamashita, D., Stimulating activity of Chinese medicinal herbs on human lymphocytes in vitro. Int. J. Immunopharmacol. 21, 149-159 (1999) 
  44. Huang, J.T., New iridoids from Oldenlandia dijfusa Roxb. Arch. Pharm. 314, 813-816 (1981) 
  45. Kim, Y, Park, E.J., Kim, J., Kim, Y.B., Kim, S.R, and Kim, Y.C. Neuroprotective constituents from Hedyotis diffusa. J. Nat. Prod. 64, 75-78 (2001) 
  46. Lu, C.M., Yang, U., Wang, P.Y, and Lin, C.C., A new acylated flavonol glycoside and antioxidant effects of Hedyotis diffusa. Planta Med. 66, 374-377 (2000) 
  47. Han, S.H., Lee, J.B., Moon, G., Moon, S.J., Won, J.H., Pak, L.G., and Lee, J.D., Studies on expression of cell cycle related genes in HL-60 cells undergoing apoptosis by the methanol extract of Hedyotis diffusa. J. Kor. Oriental Oncology 6, 99-111 (2000) 
  48. Woo, W.H., Moon, G., and Jeon, B.H., Effect of the methanol extract of Korean traditional medicine herb Oldenlandiae diffusae herba on proliferation and differentiation of cancer cells. Korean J. Oriental Medical Pathology 12, 105-111 (1998) 
  49. Kim, I.J., Lee, G.U., So, H.S., Park, R.K., Won, J.H, Moon, G., and Moon, S.J., Study on caspases activation change of HL-60 cell apoptosis by Hedyotis dijfusa's methanol extract. The Journal of Traditional Korean Medicine 10, 255-269 (2000) 

이 논문을 인용한 문헌 (1)

  1. Bang, Han-Yeol ; Yang, Eun-Ju ; Kim, Jeong-Ah ; Song, Kyung-Sik 2013. "Simultaneous HPLC Determination of Marker Compounds for the Standardization of Hedyotis diffusa" 생명과학회지 = Journal of life science, 23(8): 1025~1031 


원문 PDF 다운로드

  • ScienceON :

원문 URL 링크

원문 PDF 파일 및 링크정보가 존재하지 않을 경우 KISTI DDS 시스템에서 제공하는 원문복사서비스를 사용할 수 있습니다. (원문복사서비스 안내 바로 가기)

상세조회 0건 원문조회 0건

DOI 인용 스타일