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논문 상세정보

초록

신선초의 기능성 해명과 유용 기능성성분 탐색연구의 일환으로 신선초 지상부로부터 항산화활성물질을 분리하여 구조 해석하였다. 신선초 지상부의 열수추출물을 용매분획하여 ethyl acetate 가용 중성획분을 얻었다. 이를 Sephadex LH-20 column chromatography와 HPLC로 정제하여 항산화활성물질 2종을 단리하고, 그들 각각의 화합물을 대상으로 FAB-MS와 NMR 분석을 실시한 결과, pseudoisopsoralen과 8-methoxypsoralen(xanthotoxin)으로 동정하였다.

Abstract

Hot water extracts of Angelica keiskei aerial parts were solvent-fractionated with ethyl acetate (EtOAc) and buffers (5% $NaHCO_3$, pH 8.0; 1.0 N HCl, pH 3.0) to obtain EtOAc-soluble acidic and neutral fractions. EtOAc-soluble neutral fraction was purified by Sephadex LH-20 column chromatography and reverse phase HPLC. Assay for purification of antioxidative compounds was performed by spraying DPPH solution on thin layer chromatography. Two isolated substances were identified as pseudoisopsoralen and 8-methoxypsoralen(xanthotoxin) by FAB-MS and NMR analyses.

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이 논문을 인용한 문헌 (3)

  1. Jo, Hyun-Woo ; Park, Jong-Cheol 2008. "Phenolic Compounds Isolated from the Leaves of Angelica keiskei Showing DPPH Radical Scavenging Effect" 생약학회지, 39(2): 146~149 
  2. Son, Hyeong-U ; Nam, Dong-Yoon ; Kim, Min-Ah ; Cha, Yong-Su ; Kim, Jong-Myung ; Shin, Yong-Kyu ; Lee, Sang-Han 2011. "Inhibitory Effect of Angelica keiskei Extracts on Melanogenesis" 한국식품저장유통학회지 = Korean journal of food preservation, 18(6): 998~1001 
  3. Kim, Min-A ; Son, Hyeong-U ; Nam, Dong-Yoon ; Cha, Yong-Su ; Shin, Yong-Kyu ; Choi, Yong-Hee ; Lee, Sang-Han 2012. "Inhibitory Effect of Angelica keiskei Extract in an Atopic Dermatitis Animal Model" 한국식품저장유통학회지 = Korean journal of food preservation, 19(5): 792~798 

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