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논문 상세정보

Abstract

In yeast and human cells, the Mre11 complex, which consists of Mre11, Rad50, and Xrs2/Nbs1 proteins, participates in basic aspects of chromosome metabolism, such as the repair of meiotic DNA breaks and telomere maintenance. In this study, we isolated a full-length cDNA clone, pOsMre11, encoding a rice ortholog of the Mre11 protein. Its predicted protein sequence ($M_r$=79.2 kDa and pI value=5.91) contains a metallo-phosphoesterase domain at its N-terminal region, and a single putative DNA binding domain in the central region of the protein, with significant homology to corresponding motifs in human and yeast Mre11 proteins. The OsMRE11 gene is constitutively expressed in all tissues examined here, including leaves, roots, tillers, and meristems, as well as in undifferentiated callus cells. When 10-d-old rice seedlings were treated with $0.025\%$ methyl methanesulfonate(MMS) or 30 watts of UV-C light, they were apparently damaged by those genotoxic agents, with plants being more seriously injured by the latter. RNA gel blot analysis showed that the level of OsMRE11 mRNA remained unchanged during the 1- to 4-d incubation period with MMS. In contrast, OsMRE11 expression appeared to increase after 3 d of irradiation. In addition, treatments with salicylic acid and jasmonic acid, two important defense-related hormones, significantly activated the OsMre11 gene. Based on these results, we discuss the possible functions of the OsMre11 protein in a mechanism by which the stability of rice chromosomes is maintained.

참고문헌 (23)

  1. Bundock P, Hooykaas P (2002) Severe developmental defects, hypersensitivity to DNA-damaging agents, and lengthened telomeres in Arabidopsis MRE11 mutants. Plant Cell 14: 2451-2462 
  2. Connelly JC, Leach DR (2002) Teetering on the brink: The evolutionary conserved Mre11-Rad50 complex. Trends Biochem Sci 27: 410-418 
  3. D'Amours D, Jackson SP (2002) The Mre11 complex: At the crossroads of DNA repair and checkpoint signaling. Nat Rev 3: 317-327 
  4. Lee JH, Hong JP, Oh SK, Lee S, Choi D, Kim WT (2004) The ethylene-responsive factor like protein 1 (CaERFLP1) of hot pepper (Capsicum annuum L.) interacts in vitro with both GCC and DRE/CRT sequences with different binding affinities: Possible biological roles of CaERFLP1 in response to pathogen infection and high salinity conditions in transgenic tobacco plants. Plant Mol Biol 55: 61-81 
  5. Petrini JH, Walsh ME, DiMare C, Chen XN, Korenberg JR, Weaver DT (1995) Isolation and characterization of the human MRE11 homologue. Genomics 29: 80-86 
  6. Usui T, Ohta T, Sshiumi H, Tomizawa J, Ogawa H, Ogawa T (1998) Complex formation and functional versatility of Mre11 of budding yeast in recombination. Cell 95: 705-716 
  7. Yang SW, Jin ES, Chung IK, Kim WT (2002) Cell cycledependent regulation of telomerase activity by auxin, abscisic acid and protein phosphorylation and dephosphorylation in tobacco BY-2 suspension culture cells. Plant J 29: 617-626 
  8. Christmann M, Tomicic MT, Roos WP, Kaina B (2003) Mechanism of human DNA repair: An update. Toxicology 193: 3-34 
  9. Choi KH, Hong CB, Kim WT (2002) Isolation and characterization of drought-induced cDNA clones from hot pepper (Capsicum annuum). J Plant Biol 45: 212-218 
  10. de Jager M, van Noort J, van Gent DC, Dekker C, Kanaar R, Wyman C (2001) Human Rad50/Mre11 is a flexible complex that can tether DNA ends. Mol Cell 8: 1129-1135 
  11. Chae HS, Cho YG, Park MY, Lee MC, Eun MY, Kang BG, Kim WT (2000) Hormonal cross-talk between auxin and ethylene differentially regulates the expression of two members of the 1-aminocyciopropane-1-carboxylate oxidase gene family in rice (Oryza sativa L). Plant Cell Physiol 41: 354-362 
  12. Ljungman M, Lane DP (2004) Transcription-guarding the genome by sensing DNA damage. Nat Rev 4: 727-737 
  13. Agrawal GK, Rakwal R, Jwa NS, Agrawal VP (2002) Effects of signaling molecules, protein phosphatase inhibitors and blast pathogen (Magnaporthe grisea) on the mRNA level of a rice (Oryza sativa L.) phospholipids hydroperoxide glutathione peroxidase (OsPHCPX) gene in seedling leaves. Gene 283: 227-236 
  14. Park JA, Cho SK, Kim JE, Chung HS, Hong JP, Hwang B, Hong CB, Kim WT (2003) Isolation of cDNAs differentially expressed in response to drought stress and characterization of the Ca-LEAL1 gene encoding a new family of atypical LEA-LIKE protein homologue in hot pepper (Capsicum annuum L. cv. Pukang). Plant Sci 165: 471-481 
  15. Daoudal-Cotterell S, Gallego ME, White CI (2002) The plant Rad50/Mre11 protein complex. FEBS Lett 516: 164-166 
  16. Overmyer K, Brosche M, Kangasjarvi (2003) Reactive oxygen species and hormonal control of cell death. Trends Plant Sci 8: 335-342 
  17. Paull TT, Gellert M (2000) A mechanistic basis for Mre11 directed DNA joining at microhomologies. Proc Natl Acad Sci USA 97: 6409-6414 
  18. Stracker TH, Theunissen JWF, Morales M, Petrini JHJ (2004) The Mre11 complex and metabolism of chromosome breaks: The importance of communicating and holding things together. DNA Repair 3: 845-854 
  19. Scharer OD (2003) Chemistry and biology of DNA repair. Angew Chem Int Ed Eng 142: 2946-2974 
  20. Stratmann J (2003) Ultraviolet-B radiation co-opts defense signaling pathway. Trends Plant Sci 8: 526-533 
  21. Dolganov GM, Maser RS, Novikov A, Tosto L, Chong S, Bressan DA, Petrini JHJ (1996) Human Rad50 is physically associated with human Mre11: Identification of a conserved multiprotein complex implicated in recombinational DNA repair. Mol Cell Biol 16: 4832-4841 
  22. Puizina J, Siroky J, Mokros P, Schweizer D, Riha K (2004) Mre11 deficiency in Arabidopsis is associated with chromosomal instability in somatic cells and Spo11-dependent genome fragmentation during meiosis. Plant Cell 16: 1968-1978 
  23. Johzuka K, Ogawa H (1995) Interaction of Mre11 and Rad50: Two proteins required for DNA repair and meiosis-specific double-strand break formation in Saccharomyces cerevisiae. Genetics 139: 1521-1532 

이 논문을 인용한 문헌 (1)

  1. 2006. "" Journal of plant biology = 식물학회지, 49(6): 469~476 

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