$\require{mediawiki-texvc}$
  • 검색어에 아래의 연산자를 사용하시면 더 정확한 검색결과를 얻을 수 있습니다.
  • 검색연산자
검색연산자 기능 검색시 예
() 우선순위가 가장 높은 연산자 예1) (나노 (기계 | machine))
공백 두 개의 검색어(식)을 모두 포함하고 있는 문서 검색 예1) (나노 기계)
예2) 나노 장영실
| 두 개의 검색어(식) 중 하나 이상 포함하고 있는 문서 검색 예1) (줄기세포 | 면역)
예2) 줄기세포 | 장영실
! NOT 이후에 있는 검색어가 포함된 문서는 제외 예1) (황금 !백금)
예2) !image
* 검색어의 *란에 0개 이상의 임의의 문자가 포함된 문서 검색 예) semi*
"" 따옴표 내의 구문과 완전히 일치하는 문서만 검색 예) "Transform and Quantization"
쳇봇 이모티콘
안녕하세요!
ScienceON 챗봇입니다.
궁금한 것은 저에게 물어봐주세요.

논문 상세정보

Abstract

A peptide that inhibits angiotensin-converting enzyme (ACE) was isolated from a hydrolysate of Manila clam (Ruditapes philippinarum) proteins prepared with thermolysin. Amino acid sequence of the peptide was determined to be Leu-Leu-Pro. Chemically synthesized Leu-Leu-Pro had an $IC_{50}\;value\;of\;158\;\mu{M}$. Peptides related to the Manila clam-derived peptide were synthesized to study the structure-activity relationships. The tetrapeptide, Leu-Leu-Pro-Pro, had a very weak effect on the enzyme. However, Leu-Leu-Pro-Asn showed no inhibitory activity.

참고문헌 (15)

  1. Brewer, H.B., Jr., T. Fairwell, A. LaRue, R. Ronan, A. Houser and T.J. Bronzert. 1978. The amino acid sequence of human ApoA-I, an apolipoprotein isolated from high density lipoproteins. Biochem. Biophys. Res. Commun., 80, 623-630 
  2. EI-Dorry, H.A., H.G. Bull, K. Iwata, N.A. Thornberry, E.H. Cordes and R.L. Soffer. 1982. Molecular and catalytic properties of rabbit testicular dipeptidyl carboxypeptidase. J. Biol. Chem., 257, 14128-14133 
  3. Ferreira, S.H., D.C. Bartelt and L.J. Greene. 1970. Isolation of bradykinin-potentiating peptides from Bothrops jararaca venom. Biochemistry, 9, 2583-2593 
  4. Kinoshita, E., J. Yamakoshi and M. Kikuchi. 1993. Purification and identification of an angiotensin I-converting enzyme inhibitor from soy sauce. Biosci. Biotech. Biochem., 57, 1107-1110 
  5. Lee, T.G., Y.B. Park, D.C. Park, D.M. Yeum, I.S. Kim, Y.S. Gu, Y.H. Park and S.B. Kim. 1998. Angiotensin converting enzyme inhibitory activity in enzymatic hydrolysates of anchovy muscle protein. J. Kor. Fish. Soc., 31, 875-881 
  6. Maruyama, S., K. Nakagomi, N. Tomizuka and H. Suzuki. 1985. Angiotensin-converting enzyme inhibitor derived from an enzymatic hydrolysate of casein. II. Isolation and bradykinin-potentiating activity on the uterus and the ileum of rats. Agric. Biol. Chem., 49, 1405-1409 
  7. Matsui, T., H. Matsufuji, E. Seki, K. Osajima, M. Nakashima and Y. Osajima. 1993. Inhibition of angiotensin I-converting enzyme by Bacillus lichen iformis alkaline protease hydrolysates derived from sardine muscle. Biosci. Biotech. Biochem., 57, 922-925 
  8. Matsumura, N., M. Fujii, Y. Takeda, K. Sugita and T. Shimizu. 1993. Angiotensin I-converting enzyme inhibitory peptides derived from bonito bowels autolysate. Biosci. Biotech. Biochem., 57, 695-697 
  9. Miyoshi, S., H. Ishikawa, T. Kaneko, F. Fukui, H. Tanaka and S. Maruyama. 1991. Structures and activity of angiotensin-converting enzyme inhibitors in an $\alpha$-zein hydrolysate. Agric. Biol. Chem., 55, 1313-1318 
  10. Oshima, G., H. Shimabukuro and K. Nagasawa. 1979. Peptide inhibitors of angiotensin l-converting enzyme in digests of gelatin by bacterial collagenase. Biochim. Biophys. Acta, 566, 128-137 
  11. Titani, K., A. Koide, J. Hermann, L.H. Ericsson, S. Kumar, R.D. Wade, K.A. Walsh, H. Neurath and E.H. Fischer. 1977. Complete amino acid sequence of rabbit muscle glycogen phosphorylase. Proc. Natl. Acad. Sci. USA, 74, 4762-4766 
  12. Yang, H.Y.T., E.G. Erdos and Y.A. Levin. 1970. Dipeptidyl carboxypeptidase that converts angiotensin I and inactivates bradykinin. Biochim. Biophys. Acta, 214, 374-376 
  13. Ondetti, M.A., N.J. Williams, E.F. Sabo, J. Pluscec, E.R. Weaver and O. Kocy. 1971. Angiotensin-converting enzyme inhibitors from the venom of Bothrops jararaca. Isolation, elucidation of structure, and synthesis. Biochemistry, 10, 4033-4039 
  14. Skeggs, L.T., W.H. Marsh, J.R. Kahn and N.P. Shumway. 1954. The existence of two forms of hypertensin. J. Exp. Med., 99, 275-282 
  15. Kohama, Y., S. Matsumoto, H. Oka, T. Teramoto, M. Okabe and T. Mimura. 1988. Isolation of angiotensinconverting enzyme inhibitor from tuna muscle. Biochem. Biophys. Res. Commun., 155, 332-337 

이 논문을 인용한 문헌 (2)

  1. 2008. "" Journal of food science and nutrition, 13(3): 196~203 
  2. Park, Yeung-Beom 2010. "Characteristics of Angiotensin Converting Enzyme Inhibitory Peptides from Salt-fermented Squid Liver Sauce" 한국식품영양과학회지 = Journal of the Korean Society of Food Science and Nutrition, 39(11): 1654~1659 

원문보기

원문 PDF 다운로드

  • ScienceON :

원문 URL 링크

원문 PDF 파일 및 링크정보가 존재하지 않을 경우 KISTI DDS 시스템에서 제공하는 원문복사서비스를 사용할 수 있습니다. (원문복사서비스 안내 바로 가기)

상세조회 0건 원문조회 0건

DOI 인용 스타일