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GyeongshinhaeGihwan T1 has Controlling Effects on the Factors Associated with Obesity

The journal of applied pharmacology : the official journal of the Korean Society of Applied Pharmacology, v.13 no.1, 2005년, pp.7 - 12  

An, Hyo-Jin (College of Oriental Medicine, Kyung Hee University, College of Pharmacy, Wonkwang University) ,  Choi, In-Young (College of Oriental Medicine, Kyung Hee University, College of Pharmacy, Wonkwang University) ,  Jung, Yang-Sam (College of Oriental Medicine and Research Institute of Oriental Medicine, Dongeui University) ,  Yoon, Ki-Hyeon (College of Oriental Medicine and Research Institute of Oriental Medicine, Dongeui University) ,  Kim, Hyung-Min (College of Oriental Medicine, Kyung Hee University) ,  Hong, Seung-Heon (College of Pharmacy, Wonkwang University) ,  Shin, Soon-Shik (College of Oriental Medicine, Kyung Hee University)

Abstract AI-Helper 아이콘AI-Helper

GyeongshinhaeGihwan T1 (GGT1) is a newly developed oriental medicine to help weight control. We investigated nitric oxide production and cytokine secretion in mouse peritoneal macrophages. According to recent reports, macrophages are participated in fat accumulation and closely related with obesity....

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대상 데이터

  • Thioglycollate (TG) was purchased from Difco Laboratories (Detroit, MI, USA). Dulbecco's Modified Eagle's Medium (DMEM) containing L-arginine (84 mg/1), fetal bovine serum (FBS), and other tissue culture reagents were purchased from Gibco BRL (Grand Island, NY, USA).

데이터처리

  • Results were expressed as the mean ± SE of independent experiments, and statistical analyses were performed by oneway analysis of variance (ANOVA) with Tukey, and Duncan post hoc test to express the difference among the groups. All statistical analyses were performed using SPSS vlO.

이론/모형

  • 5×105 cells /well)were stimulated with various concentrations of GGT1 or rIFN-γ (20 U/ml) and LPS (10 ㎍/ml) plus GGT1. The amount of TNF-α and IL-12 secreted by peritoneal macrophages was measured by ELISA method after 24 h incubation. Values are mean ± SE of three independent experiments duplicate in each run.
  • To determine the effects of GGT1 on viability of mouse peritoneal macrophages, we carried out MIT assay. When we treated the cells with GGT1 (0.
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참고문헌 (22)

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