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논문 상세정보


GyeongshinhaeGihwan T1 (GGT1) is a newly developed oriental medicine to help weight control. We investigated nitric oxide production and cytokine secretion in mouse peritoneal macrophages. According to recent reports, macrophages are participated in fat accumulation and closely related with obesity. In this study, using mouse peritoneal macrophages, we have examined whether GGT1 affects the production of nitric oxide (NO), tumor necrosis factor-${\alpha}$ (TNF-${\alpha}$), and interleukin (IL)-12 by the stimulation of interferon-${\gamma}$ and lipopolysaccharide (LPS). GGT1 inhibits LPS-induced NO production in a dose-dependent manner. The decrease in NO synthesis was reflected as a decreased amount of inducible NO synthese protein. We also found that GGT1 inhibits pro-inflammatory cytokines, TNF-${\alpha}$ and IL-12 production. In mouse embryo preadipocyte 3T3-L1, GGT1 reduced the viability in a dose-dependent manner. These findings suggest that GGT1 may have potential effects in preventing and controlling adipogenesis and obesity.

참고문헌 (22)

  1. Balsiger, B.M., Murr, M.M., Poggio, J.L. and Sarr, M.G. (2000) Bariatric surgery. Surgery for weight control in patients with morbid obesity. Med Clin North Am, 84, 477-489 
  2. Barnes, P.J. (2003) Cytokine-directed therapies for the treatment of chronic airway diseases. Cytokine Growth Factor Rev, 14, 511-522 
  3. Bastard, J.P., Jardel, C., Bruckert, E., Blondy, P., Capeau, J., Laville, M., Vidal, H. and Hainque, B. (2000) Elevated levels of interleukin 6 are reduced in serum and subcutaneous adipose tissue of obese women after weight loss. J Clin Endocrinol Metab, 85, 3338-3342 
  4. Chung, H.S., An, H.J., Jeong, H.J., Won, J.H., Hong, S.H. and Kim, H.M. (2004) Water extract isolated from Chelidonium majus enhances nitric oxide and tumour necrosis factor-alpha production via nuclear factor-kappaB activation in mouse peritoneal macrophages. J Pharm Pharmacol, 56, 129-134 
  5. Connelly, L., Palacios-Callender, M. Ameixa, C., Moncada, S. and Hobbs, A.J. (2001) Biphasic regulation of NF-kappa B activity underlies the pro- and anti-inflammatory actions of nitric oxide. J Immunol, 166, 3873-3881 
  6. Das UN. (2001) Is obesity an inflammatory condition? Nutrition 17, 953-966 
  7. Dietrich M, Jialal I. (2005) The effect of weight loss on a stable biomarker of inflammation, C-reactive protein. Nutr Rev, 63, 22-28 
  8. Furuyashiki, T, Nagayasu, H., Aoki, Y, Bessho, H., Hashimoto, T, Kanazawa, K and Ashida, H. (2004) Tea catechin suppresses adipocyte differentiation accompanied by down-regulation of PPARgamma2 and C/EBPalpha in 3T3-Ll cells. Biosci Biotechnol Biochem, 68, 2353-2359 
  9. Hauner H. (2004) The new concept of adipose tissue function. Physiol Behav, 83, 653-658 
  10. Hotamisligil, G.S., Amer, P., Caro, J.F., Atkinson, R.L. and Spiegelman, B.M. (1995) Increased adipose tissue expression of tumor necrosis factor-alpha in human obesity and insulin resistance. J Clin Invest, 95, 2409-2415 
  11. Hotamisligil, G.S., Shargill, N.S. and Spiegelman, B.M. (1993) Adipose expression of tumor necrosis factor-alpha: direct role in obesity-linked insulin resistance. Science, 259, 87-91 
  12. Jeong, H.J., Chung, H.S., An, H.J., Seo, S.W., Kim, T.G., Won, J.H., Shin, J.Y., Ahn, K.S. and Kim, H.M. (2004) The immune-enhancing effect of the herbal combination Bouum-Myunyuk-Dan. Biol Pharm Bull, 27, 29-33 
  13. Kapur, S., Picard, F., Perreault, M., Deshaies, Y. and Marette, A. (2000) Nitric oxide: a new player in the modulation of energy metabolism. Int J Obes Relat Metab Disord, 24 Suppl 4, S36-40 
  14. Kim, S.J., Jeong, H.J., Lee, K.M., Ryu, H.H., Lee, K.S., Moon, B.S., Cho, K.H. and Kim, H.M. (2005) Zingansikpoongtang modulates beta-amyloid and IL-I beta-induced cytokine production and cyclooxygenase-2 expression in human astrocytoma cells U373MG. J Ethnopharmacol, 96, 279-285 
  15. Kiseleva, E.P., Puzyreva, V.P., Ogurtsov, R.P. and Kovaleva, I.G. (2002) Effect of hyperlipidemia on functional activity of peritoneal macrophages in CBA and C57Bl/6 mice. Bull Exp Biol Med, 134, 288-290 
  16. Lamas O, Moreno-Aliaga MJ, Martinez JA, Marti A (2003) NF-kappa B-binding activity in an animal diet-induced over-weightness model and the impact of subsequent energy restriction. Biochem Biophys Res Commun. 311, 533-539 
  17. Linton, M.F. and Fazio, S. (2003) Macrophages, inflammation, and atherosclerosis. Int J Obes Relat Metab Disord, 27 Suppl 3, S35-40 
  18. Nathan, C. (1992) Nitric oxide as a secretory product of mammalian cells. Faseb J, 6, 3051-3064 
  19. Petros, A., Bennett, D. and Vallance, P. (1991) Effect of nitric oxide synthase inhibitors on hypotension in patients with septic shock. Lancet, 338, 1557-1558 
  20. Weisberg, S.P., McCann, D., Desai, M., Rosenbaum, M., Leibel, R.L. and Ferrante, A.W., Jr. (2003) Obesity is associated with macrophage accumulation in adipose tissue. J Clin Invest, 112, 1796-1808 
  21. Xie, Q.W., Cho, H.J., Calaycay, J., Mumford, R.A., Swiderek, K.M., Lee, T.D., Ding, A, Troso, T. and Nathan, C. (1992) Cloning and characterization of inducible nitric oxide synthase from mouse macrophages. Science, 256, 225-228 
  22. Tracey, K.J. and Cerami, A. (1994) Tumor necrosis factor: a pleiotropic cytokine and therapeutic target. Annu Rev Med, 45, 491-503 

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