$\require{mediawiki-texvc}$
  • 검색어에 아래의 연산자를 사용하시면 더 정확한 검색결과를 얻을 수 있습니다.
  • 검색연산자
검색연산자 기능 검색시 예
() 우선순위가 가장 높은 연산자 예1) (나노 (기계 | machine))
공백 두 개의 검색어(식)을 모두 포함하고 있는 문서 검색 예1) (나노 기계)
예2) 나노 장영실
| 두 개의 검색어(식) 중 하나 이상 포함하고 있는 문서 검색 예1) (줄기세포 | 면역)
예2) 줄기세포 | 장영실
! NOT 이후에 있는 검색어가 포함된 문서는 제외 예1) (황금 !백금)
예2) !image
* 검색어의 *란에 0개 이상의 임의의 문자가 포함된 문서 검색 예) semi*
"" 따옴표 내의 구문과 완전히 일치하는 문서만 검색 예) "Transform and Quantization"
쳇봇 이모티콘
안녕하세요!
ScienceON 챗봇입니다.
궁금한 것은 저에게 물어봐주세요.

논문 상세정보

PLGA Microspheres in Hyaluronic Acid Gel as a Potential Bulking Agent for Urologic and Dermatologic Injection Therapies

Abstract

In this study, we investigated whether PLGA microspheres in combination with hyaluronic acid (HA) gel have appropriate properties as a bulking agent for urologic injection therapies and whether the implantation of PLGA microspheres and HA gel induces angiogenesis in the newly formed tissues. In order to investigate whether this bulking agent is injectable, this material was injected through 24-gauge needles into the subcutaneous dorsum of the mouse. The bulking agent was easily injected without needle obstruction. Histological analyses of the hybrid tissues at 2 weeks showed that host cells at the surrounding tissues migrated into the spaces between the implanted PLGA microspheres and formed tissue-like structures. An inflammatory response to the implants was mild at 2 weeks and diminished at 8 weeks. Importantly, extensive ingrowth of blood vessels was observed in the hybrid tissues formed by the injection of PLGA microspheres and HA, whereas blood vessels rarely formed in the hybrid tissues formed by the injection of PLGA microspheres only. The implant volume was conserved for almost the entire implantation period. Histological analyses of the distant organs of the bulking agent-implanted animals, such as the lungs, liver, heart, brain, kidney, and spleen, showed no evidence of the injected microsphere migration. These results show that PLGA microspheres in combination with HA possess the appropriate characteristics for a bulking agent for urologic injection therapies and induce extensive blood vessel formation in the hybrid tissues.

저자의 다른 논문

참고문헌 (57)

  1. Al-Hunayan, A. A., E. O. Kehinde, M. A. Elsalam, and R. S. Al-Mukhtar. 2002. Outcome of endoscopic treatment for vesicoureteral reflux in children using polydimethylsiloxane. J. Urol. 168: 2181-2183 
  2. Biswal, D. R. and R. P. Singh. 2004. Characterisation of carboxymethyl cellulose and poly-acrylamide graft copolymer. Carbohydrate Polymers 57: 379-387 
  3. Claes, H., D. Stroobants, J. Van Meerbeek, E. Verbeken, D. Knockaert, and L. Baert. 1989. Pulmonary migration following periurethral polytetrafluoroethylene injection for urinary incontinence. J. Urol. 142: 821-822 
  4. Dmochowski, R. R. and R. A. Appell. 2000. Injectable agents in the treatment of stress urinary incontinence in women: Where are we now? Urology 56: 32-40 
  5. Food and Drug Administration (USA) website. www.fda.gov 
  6. Kim, B. S., C. E. Baez, and A. Atala. 2000. Biomaterials for tissue engineering. World J. Urol. 18: 2-9 
  7. Lees, V C., T. P. D. Fan, and D. C. West. 1995. Angiogenesis in a delayed revascularization model is accelerated by angiogenic oligosaccharides of hyaluronan. Lab. Invest. 73: 259-266 
  8. Lemperle, G., N. Hazan-Gauthier, and M. Lemperle. 1995. PMMA microspheres (Artecoll) for skin and soft-tissue augmentation. Part II: Clinical investigations. Plast. Reconstr. Surg. 96: 627-634 
  9. Leonard, M. P., D. A. Canning, C. A. Peters, J. P. Gearhart, and R. D. Jeffs. 1991. Endoscopic injection of glutaraldehyde cross-linked bovine dermal collagen for correction of vesicoureteral reflux. J. Urol. 145: 115-119 
  10. Wang, J., T. T. Shih, K. J. Chang, and Y. W. Li. 2002. Silicone migration fram silicone-injected breasts: Magnetic resonance images. Ann. Plast. Surg. 48: 617-621 
  11. West, D. C., I. N. Hampson, F. Arnold, and S. Kumar. 1985. Angiogenesis induced by degradation products of hyaluronic acid. Science 228: 1324-1326 
  12. West, D. C. and S. Kumar. 1989. The effects of hyaluronate and it oligosaccharides on endothelial cell proliferation and monolayer integrity. Exp. Cell Res. 183: 179-196 
  13. Montesano, R., S. Kumar, L. Orci, and M. S. Pepper. 1996. Synergistic effect of hyaluronan oligosaccharides and vascular endothelial growth factor on angiogenesis in vitro. Lab. Invest. 75: 249-262 
  14. Savani, R. C., G. Cao, P. M. Pooler, A. Zaman, Z. Zhou, and H. M. DeLisser. 2001. Differential involvement of the hyaluranan (HA) receptors CD44 and receptor for HA-mediated motility in endothelial cell function and angiogenesis. J. Biol. Chem. 28: 36770-36778 
  15. Manna, F., M. Dentini, P. Desideri, O. De Pita, E. Mortilla, and B. Maras. 1999. Comparative chemical evaluation of two commercially available derivatives of hyaluronic acid (Hylaform${\circledR}$ from rooster combs and Restylane${\circledR}$ from Streptococcus) u.sed for soft tissue augmentation. J. Eur. Acad. Dermatol. Venereol. 13: 183-192 
  16. Newman, K. D. and M. W. McBurney. 2004. Poly(D,L lactic-co-glycolic acid) microspheres as biodegradable microcarriers for pluripotent stem cells. Biomaterials 25: 57-63 
  17. Lee, P. E., R. C. Kung, and H. P. Drutz. 2001. Periurethral autologous fat injection as treatment for female stress urinary incontinence: A randomized double-blind controlled trial. J. Urol. 165: 153-158 
  18. Malizia, A. A., H. M. Reiman, R. P. Myers, J. R. Sande, S. S. Barham, R. C. Benson, M. K. Dewanjee, and W. J. Utz. 1984. Migration and granulomatous reaction after periurethral injection of Polytef(Teflon). JAMA 251: 3277 -3281 
  19. Oldham, J. B., L. Lu, X. Zhu, B. D. Porter, T. E. Hefferan, D. R. Larson, B. L. Currier, A. G. Mikos, and M. J. Yaszemski. 2000. Biological activity of rhBMP-2 released from PLGA microspheres. J. Biomech. Eng. 122: 289-292 
  20. Sattar, A., P. Rooney, S. Kumar, D. Pye, D. C. West, I. Scott, and P. Ledger. 1994. Application of angiogenic oligosaccharides of hyaluronan increase bloodvessel numbers in skin. J. Invest. Dermatol. 103: 573-579 
  21. Kerrebroeck, P. V, F. T. Meulen, E. Farrelly, G. Larsson, L. Edwall, and A. Fianu-Jonasson. 2003. Treatment of stress urinary incontinence: Recent developments in the role of urethral injection. Urol. Res. 30: 356-362 
  22. Requena, C., M. J. Izquierdo, M. Navarro, A. Martinez, J. J. Vilata, R. Botella, J. Amorrortu, V. Sabater, A. Aliaga, and L. Requena. 2001. Adverse reactions to injectable aesthetic microimplants. Am. J. Dermatopathol. 23: 197-202 
  23. Leonard, M. P., A. Deeter, K. Hills, and L. W. Mix. 1998. Endoscopic subureteral collagen injection: Are immunological concerns justified? J. Urol. 160: 10 12-1016 
  24. Aragona, F., L. D'Urso, E. Scremin, R. Salmaso, and G. P. Glazel. 1997. Polytetrafluoroethylene giant granuloma and adenopathy: Long-term complications following subureteral polytetrafluoroethylene injection for the treatment of vesicoureteral reflux in children. J. Urol. 158: 1539-1542 
  25. Colton, C. K. 1995. Implantable biohybrid artificial organs. Cell Transplant. 4: 415-436 
  26. DeLustro, F., S. T. Smith, J. Sundsmo, G. Salem, S. Kincaid, and L. Ellingsworth. 1987. Reaction to injectable collagen: Results in animal models and clinical use. Plast. Reconstr. Surg. 79: 581-594 
  27. Achauer, B. M. 1983. A serious complication following medical-grade silicone injection of the face. Plast. Recanstr. Surg. 71: 251-254 
  28. Kim, D. I., H. J. Park, H. S. Eo, S. W. Suh, J. H. Hong, M. J. Lee, J. S. Kim, I. S. Jang, and B. S. Kim. 2004. Comparative study of seeding and culture methods to vascular smooth muscle cells on biodegradable scaffold. J. Microbiol. Biotechnol. 14: 707 - 714 
  29. Bent, A. E., J. Foote, S. Siegel, G. Faerber, R. Chao, and E. A. Gormley. 2001. Collagen implant for treating stress urinary incontinence in women with urethral hypermobility. J. Urol. 166: 1354-1357 
  30. Conrad, K. and M. R. MacDonald. 1996. Wide polytef (Gore-Tex) implants in lip augmentation and nasolabial groove correction. Arch. Otolaryngol. Head Neck Surg. 122: 664-670 
  31. Inoue, K., T. Nakamoto, A. Usui, and T. Usui. 2000. Endoscopic sub ureteral glutaraldehyde cross-linked collagen injection for the treatment of secondary vesicoureteral reflux: Comparison with primary vesicoureteral reflux in adults. J. Urol. 164: 336-339 
  32. Kershen, R. T. and A. Atala. 1999. New advances in injectable therapies for the treatment of incontinence and vesicoureteral reflux. Urol. Clin. North Am. 26: 81-94 
  33. Aboutaleb, H., S. Bolduc, A. E. Khoury, J. Upadhyay, D. J. Bagli, and W. Farhat. 2003. Polydimethylsiloxane injection versus open surgery for the treatment of vesicoureteral reflux in complete duplex system. J. Urol. 170: 1563-1565 
  34. Griffey, S., N. D. Schwade, and C. G. Wright. 2001. Particulate dermal matrix as an injectable soft tissue replacement material. J. Biomed. Mater. Res. 58: 10-15 
  35. Kim, B. S., S. I. Jeong, S. W. Cho, J. Nikolovski, D. J. Mooney, S. H. Lee, O. Jeon, T. W. Kim, S. H. Lim, Y. S. Hong, C. Y. Choi, Y. M. Lee, S. H. Kim, and Y. H. Kim. 2003. Tissue engineering of smooth muscle under a mechanically dynamic condition. J. Microbiol. Biotechnol. 13: 841-845 
  36. Herz, D., A. Hafez, D. Bagli, G. Capolicchio, G. McLorie, and A. Khoury. 2001. Efficacy of endoscopic subureteral polydimethylsiloxane injection for treatment ofvesicoureteral reflux in chirdren: A North American clinical report. J. Urol. 166: 1880-1886 
  37. Trackman, B. A. and G. E. Leach. 1995. Surgical treatment of intrinsic urethral dysfunction: Injectables (fat). Urol. Clin. North Am. 22: 665-671 
  38. Lemperle, G., V. Morhenn, and U. Charrier. 2003. Human histology and persistence of various injectable filler substances for soft tissue augmentation. Aesth. Plast. Surg. 27: 354-366 
  39. Oswald, J., M. Riccabona, L. Lusuardi, G. Bartsch, and C. Radmayr. 2002. Prospective comparison and 1-year followup of a single endoscopic subureteral polydimethylsiloxane versus dextranomer/hyaluronic acid copolymer injection for treatment of vesicoureteral reflux in children. Urology 60: 894-898 
  40. Capozza, N., M. Patricolo, A. Lais, E. Matarazzo, and P. Caione. 2001. Endoscopic treatment of vesico-ureteral reflux: Twelve years' experience. Urol. Int. 67: 228-231 
  41. Morhenn, V. B., G. Lemperle, and R. L. Gallo. 2002. Phagocytosis of different particulate dermal filler substances by human macrophages and skin cells. Dermatol. Surg. 28: 484-490 
  42. Sattar, A., S. Kumar, and D. C. West. 1992. Does hyaluronan have a role in endothelial cell proliferation in the synovium? Semin. Arthritis Rheum. 22: 37-43 
  43. Aaronson, I. A., R. A. Rames, W. B. Greene, L. G. Walsh, U. A. Hasal, and P. D. Garen. 1993. Endoscopic treatment of reflux: Migration of polytetrafluoroethylene into the lungs and brain. Eur. Urol. 23: 394-399 
  44. Hu, M., E. E. Sabelman, Y. Cao, J. Chang, and V. R. Hentz. 2003. Three-dimensional hyaluronic acid grafts promote healing and reduce scar formation in skin incision wounds. J. Biomed. Mater. Res. 67: 586-592 
  45. Knudson, C. B. and W. Knudson. 2001. Cartilage proteoglycans. Semin. Cell. Dev. Biol. 12: 69-78 
  46. Peattie, R. A., A. P. Nayate, M. A. Firpo, J. Shelby, R. J. Fisher, and G. D. Prestwich. 2004. Stimulation of in vivo angiogenesis by cytokine-loaded hyaluronic acid hydrogel implants. Biomaterials 25: 2789-2798 
  47. Sclafani, A. P., T. Romo 3rd, A. Parker, S. A. McCormick, R. Cocker, and A. Jacono. 2002. Homologous collagen dispersion (dermalogen) as a dermal filler: Persistence and histology compared with bovine collagen. Ann. Plast. Surg. 49: 181-188 
  48. Cohen, S., T. Yoshioka, M. Lucarelli, L. H. Hwang, and R. Langer. 1991. Controlled delivery systems for proteins based on poly(lactic-co-glycolic acid) microspheres. Pharm. Res. 8: 713 
  49. Yanagihara, M., T. Fujii, N. Wakamatu, H. Ishizaki, T. Takehara, and K. Nawate. 2000. Silicone granuloma on the entry points of acupuncture, venepuncture and surgical needles. J. Cutan. Pathol. 27: 301-305 
  50. Cho, E. R., S. W. Kang, and B. S. Kim. 2005. Poly(lactic-coglycolic acid) microspheres as a potential bulking agent for urological injection therapy; preliminary results. J. Biomed. Mater. Res. 72B: 166-172 
  51. Pollack, S. V. 1999. Some new injectable dermal filler materials: Hylaform, Restylane, and Artecoll. J. Cutan. Med. Surg. 3: 27-35 
  52. Joyner, B. D. and A. Atala; 1997. Endoscopic substances for the treatment of vesicoureteral reflux. Urology 50: 489-494 
  53. O'Donnell, B. and P. Puri. 1984. Treatment of vesicoureteric reflux by endoscopic injection of Teflon. Br. Med. J. 289: 79 
  54. Thomson, R. C., M. C. Wake, M. J. Yaszemski, and A. G. Mikos. 1995. Biodegradable polymer scaffolds to regenerate organs. Adv. Polym. Sci. 122: 245-274 
  55. Kang, S. W., O. Jeon, and B. S. Kim. 2005. Poly(lactic-coglycolic acid) microspheres as an injectable scaffold for cartilage tissue engineering. Tissue Engineering (in press) 
  56. Lemperle, G., N. Gauthier-Hazan, and M. Lemperle. 1998. PMMA-microspheres (Artecoll) for long-lasting correction of wrinkles: Refinements and statistical results. Aesth. Plast. Surg. 22: 356-365 
  57. Politano, V. A. 1982. Periurethral polytetrafluoroethylene injection for urinary incontinence. J. Urol. 127: 439-442 

이 논문을 인용한 문헌 (4)

  1. 2008. "" Journal of microbiology and biotechnology, 18(4): 718~724 
  2. 2008. "" Journal of microbiology and biotechnology, 18(6): 1179~1185 
  3. 2009. "" Journal of microbiology and biotechnology, 19(3): 299~306 
  4. 2009. "" Journal of microbiology and biotechnology, 19(6): 596~603 

원문보기

원문 PDF 다운로드

  • ScienceON :
  • KCI :

원문 URL 링크

원문 PDF 파일 및 링크정보가 존재하지 않을 경우 KISTI DDS 시스템에서 제공하는 원문복사서비스를 사용할 수 있습니다. (원문복사서비스 안내 바로 가기)

상세조회 0건 원문조회 0건

DOI 인용 스타일