$\require{mediawiki-texvc}$
  • 검색어에 아래의 연산자를 사용하시면 더 정확한 검색결과를 얻을 수 있습니다.
  • 검색연산자
검색연산자 기능 검색시 예
() 우선순위가 가장 높은 연산자 예1) (나노 (기계 | machine))
공백 두 개의 검색어(식)을 모두 포함하고 있는 문서 검색 예1) (나노 기계)
예2) 나노 장영실
| 두 개의 검색어(식) 중 하나 이상 포함하고 있는 문서 검색 예1) (줄기세포 | 면역)
예2) 줄기세포 | 장영실
! NOT 이후에 있는 검색어가 포함된 문서는 제외 예1) (황금 !백금)
예2) !image
* 검색어의 *란에 0개 이상의 임의의 문자가 포함된 문서 검색 예) semi*
"" 따옴표 내의 구문과 완전히 일치하는 문서만 검색 예) "Transform and Quantization"
쳇봇 이모티콘
안녕하세요!
ScienceON 챗봇입니다.
궁금한 것은 저에게 물어봐주세요.

논문 상세정보

Abstract

We recently isolated a novel probiotic strain, Lactobacillus fermentum PL9005 (KCCM-10250), from infant feces and showed that it had a potential immunoenhancing effect. In the present study, a safety assessment of the bacteria was performed using a BALB/c mouse model. Mice were administered with L. fermentum PL9005 daily for 28 days. There were no detectable changes in body weight, feed intake, or clinical signs, and no significant difference in hematological parameters or blood biochemistry between the L. fermentum PL9005-fed and control groups. Bacterial translocation was detected in the mesenteric lymph nodes, liver, and spleen of some mice with and without L. fermentum PL9005 feeding, however, the organisms were not related to ingestion of L. fermentum PL9005; this was confirmed by PCR using a species-specific primer. No gross lesions were detected in the liver, spleen, or intestine of L. fermentum PL9005-fed or control mice. Mucosal thickness in the ileum, cecum, and colon of L. fermentum PL9005-fed mice was not significantly different from that of corresponding organs in control mice. No inflammation or epithelial cell degeneration in the intestines was observed in any mice. These results indicate that ingestion of L. fermentum PL9005 is safe in mice and can be applied in the functional food market.

참고문헌 (38)

  1. Aguirre, M. and M. D. Collins. 1993. Lactic acid bacteria and human clinical infection. J. Appl. Bacteriol. 75: 95-107 
  2. Berg, R. D. 1983. Translocation of indigenous bacteria from the intestinal tract, pp. 333-352. In R. J. Hentges (ed.). Human Intestinal Microflora in Health and Disease. Academic Press, London 
  3. Boyd, H. B. 1993. Safety assessment of novel foods. Intern. Food Ingred. 5: 9-11 
  4. Hale, P. and A. Hill. 1973. The recovery of Lactobacillus sp. from the livers of healthy mice. Lab. Anim. 7: 119-124 
  5. Holzapfel, W. H., P. Haberer, J. Snel, U. Schillinger, and J. H. J. Huis in't Veld. 1998. Overview of gut flora and probiotics. Int. J. Food Microbiol. 41: 85-101 
  6. Kim, S. M., K. H. Lee, N. K. Lee, C. J. Kim, C. H. Kim, and H. D. Park. 2004. Antagonistic activity of polyfermenticin SCD against Helicobacter pylori KCTC 2948. J. Microbiol. Biotechnol. 14: 148-152 
  7. Klein, G., A. Pack, C. Bonaparte, and G. Reuter. 1998. Taxonomy and physiology of probiotic lactic acid bacteria. Int. J. Food Microbiol. 41: 103-125 
  8. Willem, M., R. Fonden, U. Svensson, M. Saxelin, L. Morelli, K. Collins, D. Brassard, E. Shiffrin, G. Mogensen, B. Grenov, S. Salminen, E. Isolauri, A. von Wright, and T. M. Sandholm. 1997. Recommendations for safety of probiotic cultures for traditional or novel foods. Demonst. Nutr. Functional. Probio. Food Newslett. 2: 2 
  9. Fukushima, M. and M. Nakano. 1996. Effects of a mixture of organisms, Lactobacillus acidophilus or Streptococcus faecalis on cholesterol metabolism in rats fed on a fat- and cholesterol-enriched diet. Brit. J. Nutr. 76: 857-867 
  10. Zhou, J. S., Q. Shu, K. J. Rutherfurd, J. Prasad, M. J. Birtles, P. K. Gopal, and H. S. Gill. 2001. Safety assessment of potential probiotic lactic acid bacterial strains Lactobacillus rhamnosus HN001, Lb. acidophilus HN017, and Bifidobacterium lactis HN019 in BALB/c mice. Int. J. Food Microbiol. 56: 87-96 
  11. Ward, L. J. H., J. C. S. Brown, and G. P. Davey. 1995. Detection of dairy Leuconostoc strains using the polymerase chain reaction. Lett. Appl. Microbiol. 20: 204-208 
  12. De Rodas, B. Z., S. E. Gilliland, and C. V. Maxwell. 1996. Hypocholesterolemic action of Lactobacillus acidophilus ATCC 43121 and calcium in swine with hypercholesterolemia induced by diet. J. Dairy Sci. 79: 2121-2128 
  13. Ford, H. R., A. Avanoglu, P. R. Boechat, R. Melgoza, R. S. LumCheong, P. Boyle, M. Garrett, and M. I. Rowe. 1996. The microenvironment influences the pattern of bacterial translocation in formula-fed neonates. J. Pediat. Surg. 31: 486-489 
  14. Fuller, R. 1991. Probiotics in man and animals. J. Appl. Bacteriol. 66: 365-378 
  15. Gill, H. S., K. J. Rutherfurd, J. Prasad, and P. K. Gopal. 2000. Enhancement of natural and acquired immunity by Lactobacillus rhamnosus (HN001), Lactobacillus acidophilus (HN017) and Bifidobacterium lactis (HN019). Brit. J. Nutr. 83: 167-176 
  16. Marteau, P. and J. C. Rambaud. 1993. Potential of using lactic acid bacteria for therapy and immunomodulation in man. Microbiol. Rev. 12: 207-220 
  17. Walter, J., G. W. Tannock, A. Tilsala- Timisjarvi, S. Rodtong, D. M. Loach, K. Munro, and T. Alatossava. 2000. Detection and identification of gastrointestinal Lactobacillus species by using denaturing gradient gel electrophoresis and speciesspecific PCR primers. Appl. Environ. Microbiol. 66: 297-303 
  18. Zhou, J. S., Q. Shu, K. J. Rutherfurd, J. Prasad, P. K. Gopal, and H. S. Gill. 2000. Acute oral toxicity and bacterial translocation studies on potentially probiotic strains of lactic acid bacteria. Food Chem. Toxicol. 38: 153-161 
  19. Park, J. H., Y. Lee, E. Moon, S. H. Seok, S. A. Cho, M. W. Baek, H. Y. Lee, D. J. Kim, and J. H. Park. 2005. Immunoenhancing effects of a new probiotic strain, Lactobaeillus fermentum PL 9005. J. Food. Prot. 68: 571-576 
  20. Fuller, R. 1992. History and development of probiotics, pp. 1-8. In Fuller, R. (ed.), Probiotics - The Scientific Basis. Chapman and Hall, London 
  21. Hull, R. 1995. Probiotics and human health. Proc. Nutr. Soc. Aust. 19: 88-93 
  22. Tortuero, F., J. Rioperez, E. Fernandez, and M. L. Rodriguz. 1995. Response of piglets to oral administration of lactic acid bacteria. J. Food Prot. 58: 1369-1374 
  23. Donohue, D. C., S. Salminen, and P. Marteau. 1998. Safety of probiotic bacteria, pp. 307. In S. Salminen and A. von Wright (eds.) Lactic Acid Bacteria. Marcel Dekker, New York, U.S.A 
  24. Gill, H. S., Q. Shu, H. Lin, K. J. Rutherfurd, and M. L. Cross. 2001. Protection against trans locating Salmonella typhimurium infection in mice by feeding the immunoenhancing probiotic Lactobacillus rhamnosus strain HN001. Med. Microbiol. Immunol. 190: 97-104 
  25. Swendseid, M. E. 1987. Biochemical assessment of protein and amino acid status, pp. 205-211. In Livingston, G. E. (ed.), Proceedings of a National Conference Sponsored by the Food and Nutrition Council of the American Health Foundation, Nutritional Status Assessment of the Individual. Food and Nutrition Press, New York, U.S.A 
  26. Kim, H. J., J. H. Kim, J. H. Son, H. J. Seo, S. J. Park, N. S. Paek, and S. K. Kim. 2004. Characterization of bacteriocin produced by Lactobacillus bulgaricus. J. Microbiol. Biotechnol. 14: 503-508 
  27. Matar, C., J. C. Valdez, M. Medina, M. Rachid, and G. Perdigon. 2001. Immunomodulating effects of milks fermented by Lactobacillus helveticus and its non-proteolytic variant. J. Dairy Res. 68: 601-609 
  28. Kato, J., K. Endo, and S. Rybka. 1997. Effects of oral administration of Lactobacillus casei on antitumor responses induced by tumor resection in mice. Int. J. Immunopharmacol. 16: 29-36 
  29. Lee, H. Y., J. H. Park, S. H. Seok, S. A. Cho, M. W. Baek, D. J. Kim, Y. H. Lee, and J. H. Park. 2004. Dietary intake of various lactic-acid bacteria suppresses type 2 helper T cell-production in antigen-primed mice splenocyte. J. Microbiol. Biotechnol. 14: 167-170 
  30. Ma, L., E. Deitch, R. Specian, E. Steffen, and R. Berg. 1990. Translocation of Lactobacillus murinus from the gastrointestinal tract. Curr. Microbiol. 20: 177-184 
  31. Gasser, F. 1994. Safety of lactic acid bacteria and their occurrence in human clinical infections. Bull. Pasteur Instit. 92: 45-67 
  32. Perdigon, G., M. E. N. de Marcias, S. Alvarez, G. Oliver, and A. P. de Ruiz Holgado. 1990. Prevention of gastrointestinal infection using immunobiological methods with milk fermented with Lactobacillus casei and Lactobacillus acidophilus. J. Dairy Res. 57: 255-264 
  33. Gordon, L. E., D. Ruml, H. J. Hahne, and C. P. Miller. 1995. Studies on susceptibility to infection following radiation. IV: The pathogenesis of endogenous bacteremia of mice. J. Exp. Med. 102: 413-424 
  34. Shu, Q., K. J. Rutherfurd, S. G. Fenwick, J. Prasad, P. K. Gopal, and H. S. Gill. 2000. Dietary Bifidobacterium lactis (HN019) enhances resistance to oral Salmonella typhimurium infection in mice. Microbiol. Immunol. 44: 213-222 
  35. Kim, S. H., S. J. Yang, H. C. Koo, W. K. Bae, J. Y. Kim, J. H. Park, Y. J. Baek, and Y. H. Park. 2001. Inhibitory activity of Bifidobacteria longum HY8001 against vero cytotoxin of Escherichia coli O157:H7. J. Food Prot. 64: 1667-1673 
  36. Bayer, A. S., A. W. Chow, D. Betts, and L. B. Guze. 1978. Lactobacillemia - report of nine cases, and important clinical and therapeutic considerations. Am. J. Med. 64: 808-813 
  37. Matsuzaki, T. 1998. Immunomodulation by treatment with Lactobacillus casei strain Shirota. Int. J. Food Microbiol. 41: 133-140 
  38. van der Kamp, J. W. 1996. Safety considerations regarding probiotic strains - conclusions of two specialist workshops. Int. Dairy Feder. Newslett. 5: 27 - 28 

이 논문을 인용한 문헌 (2)

  1. 2007. "" Journal of microbiology and biotechnology, 17(1): 104~109 
  2. 2008. "" Journal of microbiology and biotechnology, 18(2): 338~342 

원문보기

원문 PDF 다운로드

  • ScienceON :
  • KCI :

원문 URL 링크

원문 PDF 파일 및 링크정보가 존재하지 않을 경우 KISTI DDS 시스템에서 제공하는 원문복사서비스를 사용할 수 있습니다. (원문복사서비스 안내 바로 가기)

상세조회 0건 원문조회 0건

DOI 인용 스타일