• 검색어에 아래의 연산자를 사용하시면 더 정확한 검색결과를 얻을 수 있습니다.
  • 검색연산자
검색연산자 기능 검색시 예
() 우선순위가 가장 높은 연산자 예1) (나노 (기계 | machine))
공백 두 개의 검색어(식)을 모두 포함하고 있는 문서 검색 예1) (나노 기계)
예2) 나노 장영실
| 두 개의 검색어(식) 중 하나 이상 포함하고 있는 문서 검색 예1) (줄기세포 | 면역)
예2) 줄기세포 | 장영실
! NOT 이후에 있는 검색어가 포함된 문서는 제외 예1) (황금 !백금)
예2) !image
* 검색어의 *란에 0개 이상의 임의의 문자가 포함된 문서 검색 예) semi*
"" 따옴표 내의 구문과 완전히 일치하는 문서만 검색 예) "Transform and Quantization"
쳇봇 이모티콘
ScienceON 챗봇입니다.
궁금한 것은 저에게 물어봐주세요.

논문 상세정보


Myxobacterium sp. HK1, isolated from Korean soil, degrades cellulose, differentiates to fruiting body, and its 16s rDNA has $95\%$ similarity to Polyangium sp. An anticancer molecule, CDMHK, was identified from culture broth of Myxobacterium sp. HK1, and purified by Diaion HP20, Silica gel, Sephadex LH-20 chromatography, and preparative HPLC using an YMC OSD-A C18 column. The molecular structure and formula were determined to be $C_{l2}H_{l9}N_3O_2$ (M.W 237) by MS spectrometry, 300 MHz $^{1}H\;and\;^{13}C$ NMR. The CDMHK was not active against Escherichia coli, Staphylococcus aureus, and Candida albicans. However, this molecule inhibited the growth of various cancer cell lines. The $ED_{50}$ values of CDMHK were determined to be 0.147, 0.086, 0.18, 0.166, and 0.142 $\mu$g/ml against A549, SK-OV-3, SK-MEL-2, VF498, and HCTl5 cancer cell lines, respectively. In addition, the CDMHK was able to induce apoptosis of the CCRF-CEM cancer cell line, evidenced by DNA fragmentation assay and DAPI staining.

참고문헌 (28)

  1. Bae, M. A., K. Yamada, D. Uemura, J. H. Seu, and Y. H. Kim. 1998. Aburatubolactam C, a novel apoptosis-inducing substance produced by marine Streptomyces sp. SCRC A-20. J. Microbiol. Biotechnol. 8: 445-460 
  2. Dawid, W. 2000. Biology and global distribution of myxobacteria in soils. FEMS. Microbiol. Rev. 24: 403-427 
  3. Denizot, F. and R. Lang. 1986. Rapid colorimetric assay for cell growth and survival: Modifications to the tetrazolium dye procedure giving improved sensitivity and reliability. J. Immuno. Methods 22: 271-277 
  4. Gerth, K., P Washausen, G Hofel, H.lrschik, and H. Reichenbach. 1995. The jerangolids: A family of new antifungal compounds from Sorangium cellulosum (Myxobacteria). I. Production, physico-chemical and biological properties of jerangolid A. J. Antibiot. (Tokyo) 49: 70-75 
  5. Jeong, Y. W., K. S. Kim, J. Y. Oh, J. C. Park, J. H. Bang, S. W. Choi, and J. C. Lee. 2003. Growth inhibition and apoptosis induction of gastric cancer cells by copper (II) glycinate complex. J. Microbiol. Biotechnol. 13: 394-399 
  6. Park, Y. H., E. M. Chun, M. A. Bae, Y. B. Seu, K. S. Song, and Y. H. Kim. 2000. lnduction of apoptotic cell death in human jurkat T cells by a chlorophyll derivative (Cp-D) isolated from Actinidia arguta planchon. J. Microbiol. Biotechnol. 10: 27 -34 
  7. Reichenbach, H. and G. Hofle. 1993. Biologically active secondary metabolites from myxobacteria. Biotechnol. Adv. 11: 219-277 
  8. Sasse, F., B. 86hlendorf, M. Hermann, B. Kunze, E. Forche, H. Steinmetz, G Hofel, and H. Reichenbach. 1999. Melithiazols, new ${\beta}$-methoxyacrylate inhibitors of the respiratory chain isolated from myxobacteria: Production, isolation, physicochemical and biological properties. J. Antibiot. (Tokyo) 52: 721-729 
  9. Park, S., J. Kim, B. Lee, D. R. Zusman, and K. Cho. 2003. Hpk A, a histidine protein homolog, is required for fruiting body development in Myxococcus xanthus. J. Microbiol. Biotechnol. 13: 400-405 
  10. Kim, N. S., K. H. Chang, B. S. Chung, S. H. Kim, J. H. Kim, and G M. Lee. 2003. Characterization of humanized antibody produced by apoptosis-resistant CHO cells under sodium butyrate-induced condition. J. Microbiol. Biotechnol. 13: 926-936 
  11. Lim, H., M. K. Kim, Y-H. Cho, J. M. Kim, Y. Lim, and C.-H. Lee. 2004. Inhibition of cell cycle progression and induction of apoptosis in HeLa cells by HY558-1, a novel CDK inhibitor isolated from Penicillium minioluteurn F558. J. Microbiol. Biotechnol. 14: 978-984 
  12. Gerth, K., N. Bedorf, H. Irschik, G Hofle, and H. Reichenbach. 1994. The soraphens: A family of novel antifungal compounds from Sorangium cellulosum (Myxobacteria). I. Soraphen A1 alpha: Fermentation, isolation, biological properties. J. Antibiot. (Tokyo) 47: 23-31 
  13. Kunze, B., R. Jansen, F. Sasse, G H6fle, and H. Reichenbach. 1998. Apicularens A and B, new cytostatic macrolides from Chondromyces species (Myxobacteria): Production, physicochemical and biological properties. J. Antibiot. (Tokyo) 51: 1075-1080 
  14. Irschik, H., K. Gerth, G. Hofle, W. Kohl, and H. Reichenbach. 1983. The myxopyronins, new inhibitors of bacterial RNA synthesis from Myxococcus fulvus (Myxobacterales). J. Antibiot. (Tokyo) 36: 1651-1658 
  15. lrschik, H., R. Jansen, G. Hofle, K. Gerth, and H. Reichenbach. 1985. The corallopyronins, new inhibitors of bacterial RNA synthesis from Myxobacteria. J. Antibiot. (Tokyo) 38: 145-152 
  16. Dworkin, M. 1996. Recent advances in the social and developmental biology of the myxobacteria. Microbiol. Rev. 60: 70-102 
  17. Irschik, H., R. Jansen, K. Gerth, G. Haile, and H. Reichenbach. 1984. The sorangicins, novel and powerful inhibitors of eubacterial RNA polymerase isolated from myxobacteria. J. Antibiot. (Tokyo) 40: 7-13 
  18. Rechenbach, H. and G H6fle. 1993. Production ofbioactive secondary metabolites, pp. 347-397. In Dworkin, M. and D. Kaiser (eds.), Myxobacteria II. American Society of Microbiology, Washington, DC, U.S.A 
  19. Gerth, K., S. PradeIla, O. Perlova, S. Beyer, and R. Muller. 2003. Myxobacteria: Proficient producers of novel natural products with various biological activities - past and biotechnological aspects with the focus on the genus Sorangium. J. Biotechnol. 106: 233-253 
  20. Irschik, H., K. Gerth, T. Kemmer, H. Steinmetz, and H. Reichenbach. 1983. The myxovalargins, new peptide antibiotics from Myxococcus fulvus (Myxobacterales). J. Cultivation, isolation; and some chemical and biological properties. J. Antibiot. (Tokyo) 36: 6-12 
  21. Gerth, K., H. Irschik, H. Reichenbach, and W. Trowitzsch. 1980. Myxothiazol, an antibiotic from Myxococcus fulvus (Myxobacterales). I. Cultivation, isolation, physico-chemical and biological properties. J. Antibiot. (Tokyo) 33: 1474-1479 
  22. Silakowski, B., H. U. Schairer, H. Ehret, B. Kunze, S. Weinig, G. Nordsiek, P. Brandit, H. Blocker, G. Hofle, S. Beyer, and R. MUller. 1999. New lessons for combinatory biosynthesis from myxobacteria. J. Biol. Chem. 274: 37391-37399 
  23. Goodin, S., M. P. Kane, and E. H. Rubin. 2004. Epothilones: Mechanism of action and biologic activity. J. Clin. Oncol. 22: 2015-2025 
  24. Kunze, B., G Hofle, and H. Reichenbach. 1987. The aurachins, new quinoline antibiotics from myxobacteria: Production, physico-chemical and biological properties. J. Antibiot. (Tokyo) 40: 258-265 
  25. Kapuscinski, J. 1995. DAPI: A DNA-specific fluorescent probe. Biotech. Histochem. 70: 220-233 
  26. Li, X., J. Liu, and P. Gao. 1996. A simple method for the isolation of cellulolytic myxobacteria and cytophagales. J. Microbiol. Methods 25: 43-47 
  27. Gerth, K., R. Jansen, G. Refenstahl, G. Hofle, H. Irschik, B. Kunje, H. Reichenbach, and G. Thierbach. 1983. The myxalamides, new antibiotics from Myxococcus xanthus (Myxobacteriales). I. Production, physico-chemical and biological properties and mechanism of action. J. Antibiot. (Tokyo) 36: 1150-1156 
  28. Reichenbach, H. 1993. Biology of the myxobacteria: Ecology and taxonomy, pp. 13-62. In M. Dworkin and D. Kaiser (eds.), Myxobacteria II. American Society of Microbiology, Washington, DC, U.S.A 

이 논문을 인용한 문헌 (3)

  1. 2006. "" Journal of microbiology and biotechnology, 16(8): 1262~1268 
  2. 2006. "" Journal of microbiology and biotechnology, 16(9): 1369~1376 
  3. 2006. "" Journal of microbiology and biotechnology, 16(9): 1399~1404 


원문 PDF 다운로드

  • ScienceON :
  • KCI :

원문 URL 링크

원문 PDF 파일 및 링크정보가 존재하지 않을 경우 KISTI DDS 시스템에서 제공하는 원문복사서비스를 사용할 수 있습니다. (원문복사서비스 안내 바로 가기)

상세조회 0건 원문조회 0건

DOI 인용 스타일