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논문 상세정보

난소절제 랫드에서 회화나무 이소플라본의 갱년기증상 개선효과 및 신경세포 보호효과

Anti-oxidant Effect and Enhancement of Menopausal Signs by Sophorae fructus-derived Isoflavones in Ovariectomized Rats and Cytoprotective Effect in Neuro-2a

약학회지 = Yakhak hoeji v.49 no.4 , 2005년, pp.317 - 322  
Abstract

Isoflavones are reported to playa role in menopausal women as a phytoestrogen, which can replace estradiols in hormone replacement therapy (HRT). Recently; due to the risk of breast cancer by HRT, phytoestrogens (e.g. isoflavones) have been focused as an alternative therapy in menopause. In the study, we investigated whether isoflavones derived from Sophorae fructus (SISO) have more benefit than that of soybean isoflavones in estrogen deficient rats. We found that SISO effectively controled $H_2O_2$ comparing with the baseline (p<0.01 vs. post value of OVX-Cont), and the blood sugar and weight were also controlled with decreasing patterns. Additionally, in LDH assay for cytoprotective effect in Neuro-2a cell line, SISO protected cells from the damage by SNAP (p<0.05). In conclusion, SISO may have more beneficial effect in enhancing the menopausal signs than that of soybean isoflavones and the cytoprotective effect in neuron cells suggests that SISO can play a certain role in neuroprotection after menopause.

참고문헌 (19)

  1. Sagar, S., Kallo, I. J., Kaul, N., Ganguly, N. K. and Sharman, B. K.: Oxygen free radicals in essential hypertension. Mol. Cell Biochem. 111, 103 (1992) 
  2. Joo, S. S., Won, T. J., Kang, H. C. and Lee, D. I. : Isoflavones extracted from Sophorae fructus upregulate IGF-I and TGF-${\beta}$ and inhibit osteoclastogenesis in rat born marrow cells. Arch. Pharm. Res. 27, 99 (2004) 
  3. Jayagopal, V, Albertazzi, P., Kilpatrick, E. S., Howarth, E. M., Jennings, P. E., Hepburn, D. A. and Atkin, S. L. : Beneficial effects of soy phytoestrogen intake in postmenopausal women with type 2 diabetes. Diabetes Care. 25(10), 1709 (2002) 
  4. Wu, S. I., Chou, P. and Tsai, S. T. : The impact of years since menopause on the development of impaired glucose tolerance. J. Clin. Epidemiol. 54, 117 (2001) 
  5. Wakatsuki, A., Okatani, Y., Ikenou, N., Shinohara, K., Watanabe, K. and Fukaya, T. : Effect of lower dose of oral conjugated equine estrogen on size and oxidative susceptability of low-density lipoprotein particles in postmenopausal women. Circulation. 108, 808 (2003) 
  6. Lissin, L. W. and Cooke, J. P.. ; Phytoestrogens and cardiovascular health. J. Am. Coll. Cardiol. 35, 1403 (2000) 
  7. Nakajima, D., Kim, C. S., Oh, T. W, Yang, C. Y., Tatsuki, N., lgawa, S. and Fukio, O. : Suppressive effects of genistein dosage and resistance exercise on bone loss in ovariectomized rats. J. Physiol. Anthropol. 20(5), 285 (2001) 
  8. La Vecchia, C. : Reproductive surgery, menopause and breast cancer risk. Eur. J. Cancer. 35, 12 (1999) 
  9. Alice, L., Gisela, W. and Susan, R. ; Review-phytoestrogen. J. Clin. Endocrinol. Metab. 83(2), 297 (1997) 
  10. Susan, W. : Wise Women Way for the Menopausal Years. Ash. Tree Publ., Co., p. 58 & 133 (1992) 
  11. Glazier, M., Gina, M. B. and Bowman, M. : A review of the evidence for the use of phytoestrogens as a replacement for traditional estrogen replacement therapy. Arch. Int. Med. 161(9), 1161 (2001) 
  12. Joo, S. S., Kang, H. C., Lee, M. W, Choi, Y. W. and Lee, D. I. : Inhibition of IL-1${\beta}$ and IL-6 in osteoblast-like cell by isoflavones extracted from Sophorae fructus. Arch. Pharm. Res. 26, 1029 (2003) 
  13. Tamir; S., Izeael, S. and Vaya, J. : The effect of oxidative stress on ER$\alpha$ and ER$\beta$ expression. J. Steroid Biochem. 81, 327 (2002) 
  14. Ososki, A. L. and Kennelly, E. J. : Phytoestrogens: a review of the present state of research. Phytother. Res. 17, 845 (2003) 
  15. Greendale, G. A., Lee, N. P. and Arriola, E. R. : The menopause. Lancet. 353, 571 (1999) 
  16. Gaspard, U. J., Gottal, J. M. and van den Brule, F. A. : Postmenopausal changes of lipid and glucose metabolism: a review of their main aspects. Maturitas 21, 171 (1995) 
  17. Kenneth, D. R. and Classidy, A. : Dietary isoflavones: Biological effect and relevance to human health. J. Nutr. 129, 758S (1999) 
  18. Farrell, E. : Medical choices available for management of menopause. Best Pract. Res. Cl. En. 17(1), 1 (2003) 
  19. Kaufert, P., Boggs, P., Ettinger, B., Woods, N. F. and Utian, W. H. : Women and menopause: beliefs, attitudes and behaviors. The North American Menopause Society 1997 survey. Menopause. 5(4), 197202 (1997) 

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