Abstract

Excessive drinking causes 'alcohol hangover' within 8-16 hours. The cause of 'hangover' has not been elucidated exactly until now, but it is reported that it is caused by the creation of blood ethanol and acetaldehyde as ethanol metabolites. In this study vinegar extract of wood (VE) or OC-1, to which the powder extract of green tea leaves extract is added, was administered to the rats 30 minutes before the oral administration of ethanol (3 g/kg) and the blood ethanol and acetaldehyde concentration was measured in order to evaluate the efficacy of the beverage material for detoxification. As a result, the blood ethanol concentration in the group of the VE-1(vinegar crude extract) and VE-2 (double diluted solution) is statistically lower (P,0.05) than the exclusive alcohol administered control group. The blood acetaldehyde concentration of all groups of VE and OC-2, which is the double dilution of OC-1, is statistically low after 7 hours following ethanol administration. Especially, the AUC value of OC-2 group is statistically low compared to the control group. Accordingly, it indicates the conclusion that VE and OC-1, reducing the blood ethanol and acetaldehyde concentration which are two leading factors of 'hangover' after drinking, and worthwhile to be developed as beverage materials to eliminate 'hangover'.

주제어

#Vinegar extract of wood   #OC-1   #blood ethanol concentration   #blood acetaldehyde concentration   #hangover  

저자의 다른 논문

참고문헌 (25)

1. An, S. W. and Kim, Y. G. (1999). Comparison of heptic detoxification activity and reducing serum alcohol concentration of Hovenia dulsis THUNB and Alnus. Japonica Steud. Korean J Medicinal Crop Sci. 7, 263-2689 
2. Bagchi, D., Shara, M. A., Bagchi, M., Hassoun, E. A. and Stohs, S. J. (1993). Time-dependent effects of 2,3,7,8tetrachlorodibenzo-p-dioxin on serum and urine levels of malondialdehyde, formaldehyde, acetaldehyde, and acetone in rats. Toxicol. Appl. Pharmacal. 123(1), 83-8 
3. Chance, B., Oshino, N., Sugano, T. and Jamieson, D. (1974). Alcohol and Aldehyde Metabolizing System, New York, Academic Press. 169 
4. Deitrich, R. A., Collins, A. C. and Eriwin, V G. (1972). Effect of pyrazole in vivo on aldehyde metabolism in rat liver and brain. Bio. Chem. Pharmacol. 20, 2663-2669 
5. Jones, A. W. and Holmgren, P. (2003). Comparison of bloodethanol concentration in deaths attributed to acute alcohol poisoning and chronic alcoholism. Forensic Sci. 48(4), 874-9 
6. Kai, L. T. (1977). Enzymology of human alcohol metabolism. Adv. Enzymol. 45, 427 
7. Kerb, H. A. and Eggleston, L. V. (1948). Observations on transimination in liver homogemates. Biochimica et biophysica Acta. 2, 319-328 
8. Kim, C. I. (1999). Cause and effect of hangover. Food Ind. Nur. 4, 26-30 
9. Kolb, E. and Brodie, A. (1982). Modem clinical psychiatry, W. B. Saunders company, New York 
10. Lee, Y J., Kim, Y G., Lee, M. G., Chung, S. J., Lee, M. H. and Shim, C. K. (2000). Analysis of bioequivalence study using log-transformed model. Yakhak Hoeji 44, 308 
11. Lieber, C.S., Alcohol and the liver (1985). Metabolism of ethanol, metabolic effects and pathogenesis of injury. Acta. Scand. Supple. 703, 11 
12. Lieber, C. S. and Leo, M. A. (1992). Alcohol and liver. In Medical and nutritional complications of alcoholims: mechanism and management (Lieber, C. S., Ed.). Plenum Medical Book Co, New York 185 
13. Lieber, C .S., Garro, A., Leo, M. A., Mak, K. M. and Womor, T. (1986). Alcohol and cancer. Hepatology. 6, 1005-1019 
14. Paek, S. C. (1990). Ethanol oxidation is accelerated by augmentation of malate-aspartate shuttle with asparate. Korean J. Biochem. 25, 137-143 
15. Shumate, R. P., Crowther, R. F. and Zarafshan, M. (1967). A study of the metabolism rates of alcohol in the human body. J Forensic. Med. 14(3), 83-100 
16. Svanas, G. W. and Winer, H. (1985). Aldehyde dehydrogenase acitivty as the rate-limiting factor for acetaldehyde metabolism in rat liver. Arch. Biochem. Biophys. 236, 36 
17. Swift, R. and Davidson, D. (1998). Alcohol hangover, mechanism and mediators. Alcohol Health Res. World. 22, 54-60 
18. Tomita, Y, Haseba, T., Kurosu, M. and Watanabe, T. (1990). Effect of acute ethanol intoxication on aldehyde dehydrogenase in mouse. Arukoru Kenkyuto Yakubutsu Ison. 25(2), 116-28 
19. Tsukamoto, S., Kanegae, T., Isobe, E., Hirose, M. and Nagoya, T. (1998). Determinations of free and bound ethanol, acetaldehyde, and acetate in human blood and urine by headspace gas chromatography. Arukoru. Yakubutsu. Igakkai. Zasshi. 33(3), 200-209 
20. Tsukamoto, S., Muto, T., Nagoya, T., Shimamura, M., Saito, M. and Tainaka, H. (1989). Determinations of ethanol, acetaldehyde and acetate in bloodand urine during alcohol oxidation in man. Alcohol Alcohol. 24(2), 101-108 
21. Wall, T. L., Hom, S. M., Johnson, M. L., Smith, T. L. and Carr, L. G. (2000). Hangover symptoms in Asian Americans with variations in the aldehyde dehydrogenase (ALDH2) gene. J Stud. Alcohol. 61(1), 13-17 
22. Wang, S.H. (1988). Removal method of harmful ingredient that is included to wood winegar. Korean Industrial Property, Patent number 10-0212472 
23. Wiese, J. G., Shlipak, M. G. and Browner, W. S. (2000) The alcohol hangover. Ann. Intern. Med. 132(11), 897-902 
24. Winkler, K., Lundguist, F. and Tygstrup, N. (1969) The hepatic metabolism of ethanol in patient with cirrhosis of the liver J Clin. Lab. Invest. 23, 59 
25. Sainio, K., Leino, T., Huttunen, M. O. and Ylikahri, R. H. (1976). Electroencephalographic changes during experimenthangover. Clin. Neurophysiol. 40(5), 535-538 

이 논문을 인용한 문헌 (0)

1. 이 논문을 인용한 문헌 없음