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In Vivo Anti-tumor Activity of 3-Methyl-6-allylthiopyridazine in Nude Mice Xenografted with Hep-G2 Hepatocarcinoma 원문보기

The journal of applied pharmacology : the official journal of the Korean Society of Applied Pharmacology, v.13 no.2, 2005년, pp.113 - 117  

Kwon, Soon-Kyoung (College of Pharmacy, Duksung Women's University) ,  Moon, Aree (College of Pharmacy, Duksung Women's University)

Abstract ▼ AI-Helper 아이콘AI-Helper

Organosulfur compounds have been shown to exert an anti-cancer activity. In an attempt to develop novel chemopreventive and anti-cancer agents for liver cancer, we synthesized allylthiopyridazine derivatives. We have previously shown that allylthiopyridazine derivatives exert inhibitory effects on...

주제어

#Allylthiopyridazine   #hepatocarcinoma   #xenograft  

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제안 방법

  • The nude mice were used for experiments when the tumor vol- 니me reached 100 mm3. Using these animals, we investigated the inhibitory effect of K6 on the tumor growth by performing an ultrasonographic analysis to measure the final tumor volume. As shown in Fig.

대상 데이터

  • Seven-week old male Balb/C nude mice weighing 16-18g were purchased from Japan SLC Inc. (Shizuoka, Japan) and housed in filter-topped cages (26W x 42L x 18H). Animal room was maintained for constant temperature (22 ± 2℃), light (12 hr light/dark cycle) and humidity (50 ± 10%).

데이터처리

  • The results are presented as the means ± S.D. and the significance of difference between the mean of each group was analyzed using one-way analysis of variance (ANOVA) followed by a Dunnet's t-test correction, paired t-test, and linear regression analysis.
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참고문헌 (20)

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    상세보기 crossref

  2. Bandoh, K., Ishizuka, Y. and Sato, M. (1995). Effects of 3-[N(2-Chlorobenzyl)amino]-6-(1H-imidazol-l-yl) pyridazine dihydrochloride on various aromatase enzyme systems and experimental breast cancer. Arzneim-Forsch.(Drug Res.) 45, 897-900. 

  3. Chai, H.-Y., Sin, J. S., Kim, T. M., Kwon, W., Cho, Y. M., Choi, E.-K., Hwang, S.-Y., Kim, Y.-B., Moon, A., Kwon, S.-K. and Kang, J.-K. (2004). Antitumor activity of pyridazine derivative in nude mice. Kor. J Lab. Animal Sci. 20, 68-75 

  4. Cho, M. K. and Kim, S. G. (1998). Differential induction of rat hepatic microsomal epoxide hydrolase and rGSTA2 by diazines: the role of cytochrome P450 2E I-mediated metabolic activation. Chem. Biol. Interact. 116, 229-245 

    상세보기 crossref

  5. Clapper, M. L. (1998). Chemopreventive activity of oltipras. Pharma. Ther. 53, 17-27 

  6. Elka, H. K., Vincent, E. L. O. and Fung, K. P. (2002). Circumvention of multidrug resistance and reduction of cardiotoxicity of doxorubicin in vivo by coupling it with low density lipoprotein. Lift Sci. 73, 677-687 

  7. Goluboff, E. T., Shabsigh, A., Saidi, J. A., et al., (1999). Exisulind (sulindac sulfone) suppresses growth of human prostate cancer in a nude mouse xenograft model by increasing apoptosis. Urol. 53, 440-445 

    상세보기 crossref

  8. Imahie, H., Adachi, T., Nagasaki, T., Yamamura, T. and Hori, M. (1995). Effects of adriamycin, anticancer drug showing testicular toxicity, on fertility in male rats. J Toxicol. Sci. 20, 183-193 

    상세보기 crossref

  9. Jung, M. Y., Kwon, S. K. and Moon, A. (2001). Chemopreventive allylthiopyridazine derivatives induced apoptosis in SK-Hep-l hepatocarcinoma cells through a caspase-3-dependent mechanism. Eur. J Cancer 37, 2104-2110 

    상세보기 crossref

  10. Kelland, L. R. (2004). Of mice and men: values and liabilities of the athymic nude mouse model in anticancer drug development. Eur. J Cancer 40, 827-836 

    상세보기 crossref

  11. Kwon, S. K. and Hyun, J. W. (2000). Synthesis of allylthiopyridazine derivatives and their protective effects of UV-C irradiation. J Pharm. Soc. Kor. 44,9-15 

    원문보기 상세보기

  12. Kwon, S. K. (2000). Pyridazine derivatives developed as medicines. J Applied Pharmacol. 8, 1-12 

  13. Kwon, S. K. (2003). Organosulfur compounds from Allium sativum and physiological activities. J Applied Pharmacol., 11, 8-32 

  14. Labonte, P, Kadhim, S., Bowlin, T. and Mounir, S. (2000). Inhibition of tumor growth with doxorubicin in a new orthotopically impaired human hepatocellular carcinoma model. Hepatol. Res. 18, 72-85 

    상세보기 crossref

  15. Langdon, S. P. and Hendricks (1994). Preclinical phase studies in human tumor xenografts. Eur. Multicenter Follow-up Study 5, 415-422 

  16. Lee, E. J., Shin, I., Kwon, S. -K., Shin, H. -S. and Moon. A. (2003). Chemopreventive allylthiopyridazines inhibit invasion, migration and angiogenesis in hepatocarcinoma cells. Int. J. Oneal. 23, 1645-1650 

  17. Rao, C. V., Rivenson, A., Simi, B., et al., (1995). Chemoprevention of colon carcinogensis by sulindac, a nonsteroidal anti-inflamantory agent. Cancer 55, 1464-1472 

  18. Shin, H. S. and Kwon, S. K. (2003). Synthesis of allylthiopyridazine derivatives and inhibition of aflatoxin Bl-induced hepatoxicity in rats. Architecture Pharma. Res. 5, 351-357 

  19. Williams, P. L., James, R. C. and Roberts, S. M. (2000). Principles of toxicology. John Wiley & Sons, Inc. 2, 209-217 

  20. Yang, E. B., Tang, W. Y., Zhang, K., Cheng, L. Y, et al., (1997). Norcantharidin inhibits growth of human Hep-G2 cell-transplanted tumor in nude mice and prolongs host survival. Cancer Lett. 117. 93-98 

    상세보기 crossref

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