$\require{mediawiki-texvc}$
  • 검색어에 아래의 연산자를 사용하시면 더 정확한 검색결과를 얻을 수 있습니다.
  • 검색연산자
검색연산자 기능 검색시 예
() 우선순위가 가장 높은 연산자 예1) (나노 (기계 | machine))
공백 두 개의 검색어(식)을 모두 포함하고 있는 문서 검색 예1) (나노 기계)
예2) 나노 장영실
| 두 개의 검색어(식) 중 하나 이상 포함하고 있는 문서 검색 예1) (줄기세포 | 면역)
예2) 줄기세포 | 장영실
! NOT 이후에 있는 검색어가 포함된 문서는 제외 예1) (황금 !백금)
예2) !image
* 검색어의 *란에 0개 이상의 임의의 문자가 포함된 문서 검색 예) semi*
"" 따옴표 내의 구문과 완전히 일치하는 문서만 검색 예) "Transform and Quantization"
쳇봇 이모티콘
안녕하세요!
ScienceON 챗봇입니다.
궁금한 것은 저에게 물어봐주세요.

논문 상세정보

Abstract

The objective of the present investigation was to study pharmacokinetics of promethazine in Korean healthy subjects using a validated HPLC method. The HPLC analysis was performed on a Capcell Pak CN column with a mixture of acetonitrile-0.02M potassium dihydrogen phosphate (42:58, v/v, pH 6.0) and the analyte was quantified with UV detection at 251 nm. The calibration curve of the drug was linear over the range of 1-40ng/mL in human serum and the limit of quantification (LOQ) was 1 ng/mL. This analytical method was validated and shown to be specific, accurate, precise and reproducible. This method was applied to pharmacokinetic study of promethazine in Korean healthy volunteers following an oral administration of two 25 mg Himazin tablets (50 mg promethazine ${\cdot}$HCI) after overnight fasting. Serum samples were collected at given intervals over a 36-hour period (12 points) and pharmacokinetic parameters were determined from serum concentration-time profile using WinNonlin program. The estimated $AUC_{0__\infty}$, $AUC_{0_\infty}$, $C_{max}$, $T_{max}$ and $t_{1/2}$ of promethazine obtained from Korean healthy subjects were 103.84 ${\pm}$84.30 ng${\cdot}$hr/mL, 87.94${\pm}$81.02 ng${\cdot}$hr/mL, 13.43${\pm}$10.92 ng/mL, 2.00${\pm}$1.16 hr and 5.88${\pm}$3.47 hr, respectively.

참고문헌 (16)

  1. DiGregorio G. J. and Ruch E. (1980) Human whole blood and parotid saliva concentrations of oral and intramuscular promethazine. J Pharm. Sci. 69, 1457-1459 
  2. Fox, A.R. and McLoughlin D. A. (1993) Rapid, sensitive high-performance liquid chromatographic method for the quantification of promethazine in human serum with electrochemical detection. J Chromatogr. 631, 255-259 
  3. Lackner, J. R. and Graybiel, A. (1994). Use of promethazine to hasten adaptation to provocative motion. J Clin. Pharmacal. 34, 644-648 
  4. Pistos, C. and Stewart, J. T. (2003). Direct injection HPLC method for the determination of selected phenothiazines in plasma using a Hisep column. Biomed. Chromatogr. 17, 465-470 
  5. Quinn J. and Calvert R. (1976). The disposition of promethazine in man [proceedings]. J Pharm. Pharmacol. 28, suppl-59 
  6. Schwinghammer, T. L., Juhl, R. P., Dittert, L. W., Melethil, S. K., Kroboth, F. J. and Chung, V.S. (1984). Comparison of the bioavailability of oral, rectal and intramuscular promethazine. Biopharm. Drug Dispos. 5, 185-194 
  7. Song, Q. and Putcha, L. (2001) Quantitation of promethazine and metabolites in urine samples using on-line solid-phase extraction and column-switching. J Chromatogr. B. 763, 920 
  8. Stavchansky, S., Wallace, J. E., Geary, R., Hecht, G.., Robb, C. A. and Wu, P. (1987). Bioequivalence and phannacokinetic profile of promethazine hydrochloride suppositories in humans. J Pharm. Sci. 76, 441-445 
  9. Strenkoski-Nix, L.C., Ermer, J., DeCleene, S., Cevallos, W. and Mayer, P.R. (2000). Pharmacokinetics of promethazine hydrochloride after administration of rectal suppositories and oral syrup to healthy subjects. Am. J Health-Syst. Pharm. 57, 1499-1505 
  10. Taylor, G.., Houston, J. B., Shaffer J. and Mawer, G. (1983). Pharmacokinetics of promethazine and its sulphoxide metabolite after intravenous and oral administration to man. Br. J Clin. Pharmacol. 15, 287-293 
  11. Vanapalli, S. R., Kambhampati, S. P., Putcha, L. and Bourne, D. W. A. (2001). A liquid chromatographic method for the simultaneous determination of promethazine and three of its metabolites in plasma using electrochemical and UV detectors. J Chromatogr. Sci., 39, 70-72 
  12. Wallace, J. E., Shimek, E. Jr., Stavchansky, S. and Harris, S. C. (1981). Determination of promethazine and other phenothiazine compounds by liquid chromatography with electrochemical detection. Anal. Chem. 53, 960-962 
  13. Zaman, R., Honigberg, I. L., Francisco, G. E., Kotzan J. A., Stewart, J. T., Brown W. J., Shah. V. P. and Pelsor, F. R. (1986). Bioequivalency and dose proportionality of three tableted promethazine products. Biopharm. Drug Dispos. 7, 281-291 
  14. Temdrup, T. E., Dire, D. J., Madden. C. M., Davis, H., Cantor, R. M. and Gavula, D. P. (1991). A prospective analysis of intramuscular meperidine, promethazine, and chlorpromazine in pediatric emergency department patients. Ann. Emerg. Med. 20, 31-35 
  15. Bagli, M., Rao, M. L., Hoflich, G. (1994) Quantification of chlorprothixene, levomepromazine and promethazine in human serum using high-performance liquid chromatography with coulometric electrochemical detection. J Chromatogr. B Biomed. Appl. 657, 141-148 
  16. Tarkkila, P., Tom, K., Tuominen, M. and Lindgren, L. (1995). Premedication with promethazine and transdermal scopolamine reduces the incidence of nausea and vomiting after intrathecal morphine. Acta Anaesthesiol. Scand. 39, 983-986 

이 논문을 인용한 문헌 (0)

  1. 이 논문을 인용한 문헌 없음

원문보기

원문 PDF 다운로드

  • ScienceON :

원문 URL 링크

원문 PDF 파일 및 링크정보가 존재하지 않을 경우 KISTI DDS 시스템에서 제공하는 원문복사서비스를 사용할 수 있습니다. (원문복사서비스 안내 바로 가기)

상세조회 0건 원문조회 0건

DOI 인용 스타일