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논문 상세정보

Abstract

In order to isolate hyaluronidase (HAase) inhibitor from Astragali radix (AR), dried roots were extracted with ethanol, prior to sequential fractionations with n-hexane, chloroform, ethyl acetate, n-butanol, and aqueous fractions. The n-butanol soluble fraction was found to exhibit the most pronounced inhibitory effect (68%) on HAase, and the active components were separated using various chromatographic methods, including column chromatography and preparative HPLC. The active component was isolated from the n-butanol soluble fraction of AR and was structurally identified as calycosin-7-O-${\beta}$-D-glucopyranoside by LC-MS, IR, $^1H$ NMR, and $^{13}C$ NMR analysis. The $IC_{50}$ of calycosin-7-O-${\beta}$-D-glucopyranoside's HAase activity was found to be 3.7 mg/mL.

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이 논문을 인용한 문헌 (3)

  1. 2007. "" Archives of pharmacal research : a publication of the Pharmaceutical Society of Korea, 30(10): 1318~1327 
  2. 2008. "" Food science and biotechnology, 17(1): 38~45 
  3. 2008. "" Food science and biotechnology, 17(2): 402~407 

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