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논문 상세정보

Effects of Chrysanthemum boreale M. Water Extract on Serum Liver Enzyme Activities and Kupffer Cells of Carbon Tetrachloride-Induced Rats

Abstract

Effects of water extract obtained from Chrysanthemum boreale M. (CE) on serum enzyme activities and Kupffer cells of carbon tetrachloride ($CCl_4$)-induced rats were investigated. Thirty-two healthy male Sprague-Dawley rats were divided into normal (N), $CCl_4$-induced (T), CE-supplemented (C), and $CCl_4$-induced and CE-supplemented (TC) groups. $CCl_4$ injection significantly increased aspartate aminotransferase, alanine aminotransferase, lactate dehydrogenase, and alkaline phosphatase activities in serum. Significant increases in total cholesterol and triglyceride concentrations were also observed in $CCl_4$-induced rats. Oral administration of CE at 300 mg/kg body weight significantly decreased serum enzyme levels and suppressed $CCl_4$ hepatotoxicity-induced lipid profile changes. Histological findings showed fatty change, fibrosis and increased number of Kupffer cells in T group. Electron microscopic examination showed increased lysosome content and dilation of rough endoplasmic reticulum within Kupffer cells in T group, whereas CE supplement attenuated liver injury in $CCl_4$-induced liver. These results indicated CE could significantly alleviate CC4-induced hepatotoxicity injury.

참고문헌 (36)

  1. Carbon tetrachloride hepatotoxicity: An example of free radical-mediated injury , Williams, A.T.;Burk, R.F. , Semin. Liver Dis. / v.10,pp.279-284, 1990
  2. Toxicology , Amdur, M.O.;Doull, J.;Klassen, C.D. , / v.,pp., 1991
  3. Increased procollagen mRNA levels in $CCI_4$-induced liver fibrosis in rats , Pierce, R.A.;Glaug, M.R.;Greco, R.S.;Mackenzie, J.W.;Boyd, C.D.;Deak, S.B. , J. Biol. Chem. / v.262,pp.1652-1658, 1987
  4. A new direction in the srudy of carbon tetrachloride hepatotoxicity , Recknagel, R.O. , Life Sci. / v.33,pp.401-408, 1983
  5. Mechanisms of carbon tetrachloride toxicity , Recknagel, R.O.;Glende, E.A.;Dolak, J.A.;Waller, R.L. , Pharmacol. Ther. / v.43,pp.139-154, 1989
  6. Activation of Kupffer cells during the course of carbon tetrachloride-induced liver injury and fibrosis in rats , Luckey, S.W.;Petersen, D.R. , Exp. Mol. Pathol. / v.71,pp.226-240, 2001
  7. Pathogenesis of liver fibrosis: Role of oxidative stress , Poli, G. , Mol. Aspects Med. / v.21,pp.49-98, 2000
  8. Biologically active products of stimulated liver macrophages (Kupffer cells) , Decker, K. , Eur. J Biochem. / v.192,pp.245-252, 1990
  9. Non-parenchymal cells and hepatotoxicity , Laskin, D.M. , Semin. Liver Dis. / v.10,pp.293-304, 1990
  10. Comparative study of cytotoxicity tumor necrosis factor and prostaglandin release after stimulation of rat Kupffer cell, murine Kupffer cells and inflamatory liver macrophages , Decker, T.;Lohmann-Mattes, M.L.;Karck, U.;Deters, J.;Decker, K. , J. Leukoc. BioI. / v.45,pp.139-146, 1989
  11. Present aspects of the use of medicinal plants in traditional medicine , Marini-Bettolo, G.B. , J. Ethnopharmacol. / v.2,pp.5-7, 1980
  12. Preliminary evaluation of the antihepatotoxic activity of Kamilari, a polyherbal formulation , Rajesh, M.G.;Latha, M.S. , J. Ethnopharmacol. / v.91,pp.99-104, 2004
  13. Isolation and structure elucidation of radical scavengers from Chrysanthemum boreale Makino , Han, Y.S. , Kor. J Medicinal Crop Sci. / v.11,pp.1-4, 2003
  14. Chinese herbal medicine , DanBensky, R.;Andrew, G. , / v.,pp., 1986
  15. Antibacterial activity and chemical composition of essential oil of Chrysanthemum boreale , Kim, K.J.;Kim, Y.H.;Yu, H.H.;Jeong, S.I.;Cha, J.D.;Kil, B.S.;You, Y.O. , Planta Med. / v.69,pp.274-277, 2003
  16. Flavonoids from Cirsium Rhinoceros , Lee, H.B.;Kwak, J.H.;Zee, O.P.;Yoo, S.J. , Arch. Pharm. Res. / v.17,pp.273-277, 1994
  17. Effects of Sesquiterpene lactones isolated from Chrysanthemum boreale M. against sarcoma 180 implanted in ICR Mice , Nam, S.H.;Choi, S.D.;Choi, J.S.;Jang, D.S.;Choi, S.U.;Yang, M.S. , J. Kor. Food Nutr. / v.26,pp.144-148, 1997
  18. Structural analogues of cumambrin B from the flower of Chrysanthemum boreale M , Jang, D.S.;Yang, M.S.;Ha, T.J.;Park, K.H. , Arch. Pharm. Res. / v.21,pp.591-594, 1998
  19. A new guaianolide as apoptosis inhibitor from Chrysanthemum boreale M , Lee, J.R.;Yang, M.S.;Jang, D.S.;Ha, T.J.;Park, K.M.;Lee, C.H.;Kho, Y.H.;Park, K.H. , Planta Med. / v.67,pp.585-587, 2001
  20. A simple method for the isolation and purification of total lipids from animal tissues , Folch, J.;Lees, M.;Sloane, Gh. , J. BioI. Chem. / v.226,pp.497-509, 1957
  21. Protective effects of vitamin E on carbon tetrachloride-induced liver damage in rats , Naziroglu, M.;Cay, M.;Ustundag, B.;Aksakal, M.;Yekeller, H. , Cell Biochem. Funct. / v.17,pp.253-259, 1999
  22. A comparative study of the efficacy of Pavetta indica and Osbekia octandra in the treatment of liver dysfunction , Thabrew, M.I.;Joice, P.D.;Rajatissa, W. , Planta Medica / v.53,pp.239-241, 1987
  23. Tests in liver and biliary tract disease;Varley's Practical Clinical Biochemistry , Wells, F.E.;Gowenlock, H.A. , / v.,pp., 1988
  24. Enzymes in hepatic disease;Diagnostic Enzymology , Zimmerman, H.J.;Seef, L.B.;Goodly, E.I.(ed.) , / v.,pp., 1970
  25. Role of plant metabolites in toxic liver injury , Gole, M.K.;Dasgupta, S. , Asia Pac. J Clin. Nutr. / v.11,pp.48-50, 2002
  26. Hepatoprotective activity of leaves of Kalanchoe pinnata Pers , Yadav, N.P.;Dixit, V.K. , J. Ethnopharmacol. / v.86,pp.197-202, 2003
  27. Evaluation of the efficacy of Lawsonia alba in the alleviation of carbon tetrachloride- induced oxidative stress , Ahmed, S.;Rahman, A.;Alam, A.;Saleem, M.;Athar, M.;Sultana, S. , J. Ethnopharmacol. / v.69,pp.157-164, 2000
  28. Spirulina maxima prevents induction of fatty liver by carbon tetrachloride in the rat , Torres-Duran, P.V.;Miranda-Zamora, R.;Paredes-Carbajal, M.C.;Mascher, D.;Ble-Castillo, J.;Diaz-Zagoya, J.C.;Juraez-oropeza, M.A. , Biochem. Molecular BioI. lnt. / v.44,pp.787-793, 1998
  29. Effect of carbon ?tetrachloride on hepatic synthesis and release of triglycerides , Maling, H.M.;Frank, A.;Horning, M.G. , Biochimica et Biophysica Acta / v.64,pp.540-545, 1962
  30. Studies of biochemical changes in subcellular particles of rat liver and their relationship to a new hypothesis regarding the pathogenesis of carbon tetrachloride fat accumulation , Recknagel, R.;Lombardi, B. , J. BioI. Chem. / v.236,pp.564-569, 1961
  31. Therapeutic effect of melatonin on carbon tetrachloride-induced acute liver injury in rats , Ohta, Y.;Kongo, M.;Sasaki, E.;Nishida, K.;Ishiguro, I. , J. Pineal Res. / v.28,pp.119-126, 2000
  32. The effect of diet and vitamin E on liver injury due to carbon tetrachloride , McLean, A.E. , Br. J. Exp. Pathol. / v.48,pp.632-636, 1967
  33. Protective effect of Liver, a herbal formulation against erythromycin estolate induced hepatotoxicity in rats , Venkateswaran, S.;Pari, L.;Viswanathan, P.;Venugopal, P.M. , J. Ethnopharmacal. / v.57,pp.161-167, 1997
  34. Role of plant metabolites in toxic liver injury , Gole, M.K.;Dasgupta, S. , Asia Pac. J. Clin. Nutr. / v.11,pp.48-50, 2002
  35. Roles of oxidative stress in activation of Kupffer and Ito cells in liver fibrogenesis , Tsukamoto, H.;Rippe, R.;Niemela Lin M. , J. Gastroenterol. HepatoI. / v.10,pp.S50-S53, 1995
  36. Protective effect of Rhinax, a herbal formulation, against $CCl_4$-induced liver injury and survival in rats , Dhuley, J.N.;Naik, S.R. , J. Ethnopharmacol. / v.56,pp.159-164, 1997

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