$\require{mediawiki-texvc}$
  • 검색어에 아래의 연산자를 사용하시면 더 정확한 검색결과를 얻을 수 있습니다.
  • 검색연산자
검색연산자 기능 검색시 예
() 우선순위가 가장 높은 연산자 예1) (나노 (기계 | machine))
공백 두 개의 검색어(식)을 모두 포함하고 있는 문서 검색 예1) (나노 기계)
예2) 나노 장영실
| 두 개의 검색어(식) 중 하나 이상 포함하고 있는 문서 검색 예1) (줄기세포 | 면역)
예2) 줄기세포 | 장영실
! NOT 이후에 있는 검색어가 포함된 문서는 제외 예1) (황금 !백금)
예2) !image
* 검색어의 *란에 0개 이상의 임의의 문자가 포함된 문서 검색 예) semi*
"" 따옴표 내의 구문과 완전히 일치하는 문서만 검색 예) "Transform and Quantization"
쳇봇 이모티콘
안녕하세요!
ScienceON 챗봇입니다.
궁금한 것은 저에게 물어봐주세요.

논문 상세정보

Abstract

Aldose reductase catalyzes the conversion of glucose into sorbitol. Inhibiting this enzyme in diabetes mellitus can delay or prevent pathogenic process. Aldose reductase inhibitor was screened from Korean fermented soybean pastes (Doen-jang) and purified via sequential processes of ethanol extraction, HP-20 column chromatography, ethyl acetate extraction, silica gel column chromatography, and crystallization. Aldose reductase inhibitor was identified as genistein with molecular weight of 270 Da and molecular formula of $C_{15}H_{10}O_5$ based on UV spectrometry, $^1H$ and $^{13}C\;NMRs$, and mass spectrometry. Genistein inhibited aldose reductase of pig lens with $IC_{50}$ level of $20\;{\mu}M$. Because genistein was effective against aldose reductase of animal source, it may be a potential therapeutic agent for diabetic complications.

참고문헌 (36)

  1. Overview of the complications of diabetes , Santiago, J.V. , Clin. Chem. / v.32,pp.48-53, 1986
  2. Diabetes mellitus and its degenerative complications: a prospective study of 4400 patients observed between 1947 and 1973 , Pirart, J. , Diabetes Care / v.1,pp.168-188, 1978
  3. Tolrestat for mild diabetic neuropathy , Dario, G.;Teresa, S. , Ann. Int. Med. / v.118,pp.7-11, 1993
  4. Hyperglycemic pseudohypoxia and diabetic complications , Joseph, R.W.;Katherine, C.;Myrto, F. , Diabetes / v.42,pp.801-813, 1993
  5. Handbook of Diabetes , Williams, G.;John, P. , / v.,pp.44-45, 1992
  6. Inhibition of aldehyde reductase by aldose reductase inhibitors , Sanai, S.;Peter, F.K. , Biochem. Pharmacol. / v.40,pp.1033-1042, 1990
  7. Polyol metabolism and complications of diabetes mellitus , Gabby, K.H. , Hyperglycemia / v.12,pp.512-536, 1975
  8. Reversal of diabetic cataract by sorbinil, an aldose reductase inhibitor , Annette, B.M.;Cruz, E. , Diabetes / v.34,pp.15-21, 1985
  9. Aldose reductase and complications of diabetes , David, G.C.;Kinoshita, J.H.;Peter, F.K. , Ann. Int. Med. / v.101,pp.82-91, 1984
  10. The involvement of aldose reductase in diabetic complications , Kinoshita, J.H.;Nishimura, C. , Diabetes Metab. Rev. / v.4,pp.323-333, 1988
  11. Hyperglycemia, polyol metabolism and complications of diabetes mellitus , Mistry, K.P.;Annette, B.M.;Diecke, F.P. , Biochem. J. / v.250,pp.523-530, 1989
  12. Mechanisms for D-glucose inhibition of myo-inositol influx into rat lens , Kishor, P.M.;Annette, B.M.;Friedrich, P.J. , Diabetes / v.42,pp.1737-1744, 1993
  13. Effects of treatment with myo-inositol or its 1,2, 6-triphosphate(PP56) on nerve conduction in streptozotocin-diabetes , Anne, L.C.;Nigel, A.C.;Claudia, B.E. , Eur. J. Pharmcol. / v.237,pp.257-263, 1993
  14. Aldose reductase inhibitors: A potential new class of agents for the pharmacological control of certain diabetic complications , Kador, P.F.;Kinoshita, J.H.;Sharpless, N.E. , J. Med. Chem. / v.28,pp.841-849, 1985
  15. Aldose reductase inhibitors and their potential for the treatment of diabetic complications , David, R.T.;Elizabeth, J.S.;Lara, T.D. , Tip. / v.15,pp.293-297, 1994
  16. Ponalrestat: A potent and specific inhibitor of aldose reductase , Walter, H.J.;Ward, C.M.;Sennitt, H.R. , Biochem. Pharmcol. / v.39,pp.337-346, 1990
  17. Kinetic and structural effects of activation of bovine kidney aldose reductase , Grimshaw, C.E.;Shahbaz, M.;Jahangiri, G. , Biochemistry / v.28,pp.5343-5353, 1989
  18. Search for naturally occuring substances to prevent the complications of diabetes , Yoshihito, O.;Noriaki, M.;Katsuhisa, S. , Chem. Pharm. Bull. / v.43,pp.1385-1387, 1995
  19. WF-2421, an aldose reductase inhibitor produced from a fungus, Humicola grisea , Motoaki, N.;Yasuhisa, T. , J. Antibiot. / v.42,pp.130-135, 1990
  20. Bovine lens aldose reductase , Anjana, B.H.;James, M.C. , Biochem. J. / v.219,pp.33-39, 1984
  21. Purification and identification of squalene synthase inhibitor isolated from fermented soybean paste , Choi, S.W.;Kim, D.S.;Park, C.S.;Baik, M.Y. , Food Sci. Biotechnol. / v.14,pp.89-93, 2005
  22. Reduction of benzo(a)pyren-induced mouse forestomach neoplasms in mice given nitrite and dietray soy sauce , Benjamin, H.;Storkson, J.;Tallas, P.G.;Pariza, M.W. , Food Chem. Toxicol. / v.26,pp.671-678, 1988
  23. Inhibition of benzo(a)pyren-induced mouse forestomach neoplasia by dietry soy sauce , Benjamin, H.;Storkson, J.;Nagahara, A.;Pariza, M.W. , Cancer Res. / v.51,pp.2940-2942, 1991
  24. Antioxidative and antimutagenic characteristics of melanoidin related products , Cheigh, H.S.;Lee, C.Y. , J. Korean Soc. Food Sci. Nutr. / v.22,pp.246-252, 1993
  25. Antioxidant characteristics of melanidin related products fractionated from fermented soybean sauce , Cheigh, H.S.;Lee, J.S.;Moon, G.S.;Park, K.Y. , J. Korean Soc. Food Sci. Nutr. / v.22,pp.570-575, 1993
  26. Effects of protease inhibitors on radiation transformation in vitro , Kennedy, A.R.;Little, J.B. , Cancer Res / v.41,pp.2103-2108, 1981
  27. Bowman-Birk soybean protease inhibitor as an anti carcinogen , Yavelow, J.;Finalay, T.H.;Kennedy, A.R.;Troll, W. , Cancer Res. / v.43,pp.2454-2459, 1983
  28. Supression of dimethylhydrazine-induced carcinogenesis in mice by dietry addition of Bowman-Birk protease inhibitor , Clair, W.H.;Billing, P.C.;Carew, J.A.;McGandy, C.K.;Newberne, P.;Kennedy, A.R. , Cancer Res. / v.50,pp.580-586, 1990
  29. Inositol and inositol hexaphosphate supree cell proliferation and tumor formation in CD-1 mice , Shamsuddin, A.M.;Ullah, A.;Chakravarthy, A.K. , Carcinogenesis / v.10,pp.1461-1463, 1989
  30. Supression of large intesinal cancer in F344 rats by inositol hexaphosphate , Shamsuddin, A.M.;Elsayed, A.M.;Ullah, A. , Carcinogenesis / v.9,pp.577-580, 1988
  31. Genistein, daidzein, and their ${\beta}$-glycoside conjugates: antitumor isoflavones in soybean foods from American and Asian diets , Coward, L.;Barnes, N.C.;Stechell, K.D.R.;Barnes, S. , J. Agric. Food Chem. / v.41,pp.1961-1967, 1993
  32. Genistein inhibition of the human breast cancer cells: Independence from estrogen receptors and the multi-drug resistance gene , Peterson, G.;Barnes, S. , Biochim. Biophys. Res. Commun. / v.179,pp.661-667, 1991
  33. Mechanism initiating cataract formation , Kinoshita, J.H. , Invest. Ophthalmol. / v.73,pp.713-724, 1974
  34. Five new C-methyl flavonoids the potent aldose reductase inhibitors from Matteuccia orientalis TREV , Purusotam, B.;Shigetoshi, K.;Koji, H. , Chem. Pharm. Bull. / v.43,pp.1558-1564, 1995
  35. Inhibition of lens aldose reductase by flavonoids , Shimizu, M.;Ito, T.;Terashima, S.;Hayashi, T.;Arisawa, M.;Morita, N.;Kurokawa, S.;Ito, K.;Hashimoto, Y. , Phytochem / v.23,pp.1885-1888, 1984
  36. Isoflavones: Source and metabolism;Handbook of Nutraceuticals and Functional Foods , Hendrich, S.;Murphy, P.A.;Wildman, R.E.C.(ed.) , / v.,pp.55-75, 2001

이 논문을 인용한 문헌 (0)

  1. 이 논문을 인용한 문헌 없음

원문보기

원문 PDF 다운로드

  • ScienceON :

원문 URL 링크

원문 PDF 파일 및 링크정보가 존재하지 않을 경우 KISTI DDS 시스템에서 제공하는 원문복사서비스를 사용할 수 있습니다. (원문복사서비스 안내 바로 가기)

상세조회 0건 원문조회 0건

DOI 인용 스타일