$\require{mediawiki-texvc}$
  • 검색어에 아래의 연산자를 사용하시면 더 정확한 검색결과를 얻을 수 있습니다.
  • 검색연산자
검색연산자 기능 검색시 예
() 우선순위가 가장 높은 연산자 예1) (나노 (기계 | machine))
공백 두 개의 검색어(식)을 모두 포함하고 있는 문서 검색 예1) (나노 기계)
예2) 나노 장영실
| 두 개의 검색어(식) 중 하나 이상 포함하고 있는 문서 검색 예1) (줄기세포 | 면역)
예2) 줄기세포 | 장영실
! NOT 이후에 있는 검색어가 포함된 문서는 제외 예1) (황금 !백금)
예2) !image
* 검색어의 *란에 0개 이상의 임의의 문자가 포함된 문서 검색 예) semi*
"" 따옴표 내의 구문과 완전히 일치하는 문서만 검색 예) "Transform and Quantization"
쳇봇 이모티콘
안녕하세요!
ScienceON 챗봇입니다.
궁금한 것은 저에게 물어봐주세요.

논문 상세정보

Abstract

To develop functional food and anti-obesity drug through inhibition of dietary lipid absorption, inhibitory effects of herb extracts on pancreatic lipase were investigated. Due to high yield and simplicity of isolation, lipase inhibitor (ELI) was isolated from ethyl acetate extract of Eugenia aromaticum, which showed highest inhibitory activity, and characterized for development of novel functional material. Stability of ELI at high temperature and low pH was investigated. Results showed ELI is relatively stable under thermal and acidic conditions, reversible, and noncompetitive inhibitor of pancreatic lipase.

참고문헌 (22)

  1. Orlistat:its current status as an anti-obesity drug , Ballinger, A.;Peikin, S.I.R. , Eur. J. Pharm. / v.440,pp.109-117, 2002
  2. The underlying basis for obesity:relationship to cancer , Bray, G.A. , J. Nutr. / v.132,pp.3451S-3455S, 2002
  3. Dietary fat intake does affect obesity , Bray, G.A.;Popkin, B.M. , Am. J. Clin. Nutr. / v.68,pp.1157-1173, 1998
  4. Dietary fat affects obesity rate , Bray, G.A.;Popkin, B.M. , Am. J. Clin. Nutr. / v.70,pp.572-573, 1999
  5. Orlistat (Ro 18-0647), a lipase inhibitor,in the treatment of human obesity:a multiple dose study , Drent, M.L.;Larsson, I.;William-Olsson, T.;Quaade, F.;Czubayko, F.;Bergmann, K.;Strobel, W.;Sjostrom, L.;van der Veen, E.A. , Int. J. Obesity / v.19,pp.221-226, 1995
  6. Structure and function of gastrointestinal lipases , Embleton, J.K.;Pouton, C.W. , Adv. Drug. Deliv. Rev. / v.25,pp.15-32, 1997
  7. Prevalence and trends in obesity among US adults,1999-2000 , Flegal, K.M.;Carroll, M.D.;Ogden, C.L.;Johnson, C.L. , JAMA / v.288,pp.1723-1727, 2002
  8. Covalent inhibition of digestive lipases an in vitro study , Garugouri, Y.;Ransac, S.;Verger, R. , Biochimica. et Biophysica. Acta. / v.1334,pp.6-37, 1997
  9. Studies on the inhibition of pancreatic and microbial lipases by soybean proteins , Garugouri, Y.;Julien, R.;Pieroni, G.;Verger, R.;Sarda, L. , J. Lipid Res. / v.25,pp.1214-1221, 1984
  10. Anti-obesity effects in rodents of dietary teasaponin, lipase inhibitor , Han, L.K.;Kimura, Y.;Kawashima, M.;Takaku, T.;Taniyama, T.;Hayashi, T.;Zheng, Y.N.;Okuda, H. , Int. J. Obes. Rel. Metab Dis. / v.25,pp.1459-1464, 2001
  11. Flavin dimers with lipase inhibitory activity from Cassia nomame , Hatano, T.;Yamashita, A.;Hashimoto, T.;Ito, H.;Kubo, N.;Yoshiyama, M.;Shimura, S.;Itoh, Y.;Okuda, T.;Yoshida, T. , Phytochemistry / v.46,pp.893-900, 1997
  12. Lipase inhibitor for the treatment of acne , Higaki, S. , J. Molecular Catalysis B : Enzymatic. / v.22,pp.377-384, 2003
  13. Green tea extract $(AR25^{\circledR})$ inhibits lipolysis of triglycerides in gastric and duodenal medium in vitro , Juhel, C.;Armand, M.;Pafumi, Y.;Rosier, C.;Vandermander, J.;Lairon, D. , J. Nutr. Biochem. / v.11,pp.45-51, 2000
  14. Control of canine gastric emptying of fat by lipolytic products , Meyer, J.H.;Elashoff, J.D.;Domeck, M.;Levy, A.;Jehn, D.;Hlinka, M.;Lake, R.;Graham, L.S.;Gu, Y.G. , Am. J. Physiol. / v.266,pp.1017-1035, 1994
  15. Role of small intestine in caloric compensations to oil premeals in rats , Meyer, J.H.;Hlinka, M.;Khatibi, A.;Raybould, H.E.;Tso, P. , Am. J. Physiol. / v.275,pp.R1320-R1333, 1998
  16. A new spectrophotometric method for the detection of lipase activity using 2,4-dinitrophenyl butyrate as a substrate , Mosmuller, E.W.J.;Van Heemst, J.D.H.;Van Delden, C.J.;Franssen, M.C.R.;Engbersen, J.F.J. , Biocatalysis / v.5,pp.279-287, 1992
  17. Effect of Orlistat-Assisted Weight Loss in Decreasing Coronary Heart Disease Risk in Patients with Syndrome X , Reaven, G.;Segal, K.;Hauptman, J.;Boldrin, M.;Lucas, C. , Am. J. Cardiol. / v.87,pp.827-831, 2001
  18. Inhibitor Effect on Lipase Activity of Extracts from Medicinal Herbs , Shimura, S.;Tsuzuki, W.;Kobayashi, S.;Suzuki, T. , Biosci. Biotech. Biochem. / v.56,pp.1478-1479, 1992
  19. Degree of in vivo inhibition of human gastric and pancreatic lipases by Orlistat (Tetrahydrolipstatin,THL) in the stomach and small intestine , Sternby, B.;Hartmann, D.;Borgsrom, B.;Nilsson, A. , Clin. Nutr. / v.21,pp.395-402, 2002
  20. Anti-obesity effects of lipase inhibitor CT-II, an extract from edible herbs, Nomame herba, on rats fed a high-fat diet , Yamamoto, M.;Shimura, S.;Itoh, Y.;Ohsaka, T.;Egawa, M.;Inoue, S. , Int .J. Obes. / v.24,pp.758-764, 2000
  21. Obesity , Yanovski, S.Z.;Yanovski, J.A. , N. Engl. J. Med. / v.346,pp.591-602, 2002
  22. Salacia reticulata and its polyphenolic constituents with lipase inhibitory and lipolytic activities have mild antiobesity effects in rats , Yoshikawa, M.;Shimoda, H.;Nishida, N.;Takada, M.;Matsuda, H. , J. Nutr. / v.132,pp.1819-1824, 2002

이 논문을 인용한 문헌 (0)

  1. 이 논문을 인용한 문헌 없음

원문보기

원문 PDF 다운로드

  • ScienceON :

원문 URL 링크

원문 PDF 파일 및 링크정보가 존재하지 않을 경우 KISTI DDS 시스템에서 제공하는 원문복사서비스를 사용할 수 있습니다. (원문복사서비스 안내 바로 가기)

상세조회 0건 원문조회 0건

DOI 인용 스타일