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Effect of Chelation with Calcium Disodium EDTA on Haemato-biochemical and Trace Mineral Profile in Blood from Lead Exposed Calves

Asian-Australasian journal of animal sciences, v.18 no.8, 2005년, pp.1130 - 1134  

Patra, R.C. (Division of Medicine, Indian Veterinary Research Institute) ,  Swarup, D. (Division of Medicine, Indian Veterinary Research Institute)

Abstract AI-Helper 아이콘AI-Helper

An experiment was performed using 20 calves of about one-month old to investigate the effect of chelation therapy with calcium disodium ethylenediaminetetraacetate ($CaNa_2$EDTA) alone or along with antioxidant $\alpha$-tocopherol in lead loaded calves on blood trace minerals, ...

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제안 방법

  • Blood samples were collected by jugular venepuncture before the start of the chelation treatment (day 0) and, thereafter, on days 2, 4, 7 and 10 for haematobiochemical analysis. Approximately, 3 ml of blood was collected separately into nitric acid washed vials for wet digestion (Kolmer et al.
  • 5 mg/kg body weight as 10% solution daily through oral route as a drench for 28 days, where as calves of group A was given no treatment to serve as unexposed controls. Then the lead was withdrawn at the end of 28 days and lead-exposed calves were randomly divided into 3 equal groups, B1, B2 and B3 of 5 calves each for therapeutic trial as follows.
  • Twenty crossbred cal.,es, fed with only whole milk for first one month and subsequently, with whole milk and calf starter and, green fodder ad lib, were used for the experiment.
  • Twenty crossbred calves, fed with only whole milk for first one month and subsequently, with whole milk and calf starter and, green fodder ad lib, were used for the experiment. At the age of one month the calves were randomly divided into two groups, A and B of 5 and 15 animals each.

데이터처리

  • Data were analyzed statistically using two-way ANOVA to find out the significance between the means at different periods and of different therapeutic groups (Snedecor and Cochran, 1967).
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참고문헌 (30)

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