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Obesity can be defined as a metabolic disease due to an increased fat accumulation in the body caused by an imbalance of calorie intake and output The prevalence of obesity has increased substantially over the past 2-3 decades in developed and developing countries. The health impact of weight gain is so marked that obesity has now been classified as a major global public health problem In order to investigate the effect of diet conversion and oral administration of Platycodon grandiflorum extracts on the treatment of obesity, male Spraque-Dawley rats were divided into four groups: a group converted to normal diet (Control group), a group maintained high fat (30%) diet (H), and two groups with Platycodon grandiflorum extract added to the previously mentioned two groups. All animals were fed high fat diet for 7 weeks to induce the obesity. Then they were divided as mentioned above. Animals were fed experimental diet and Platycodon grandiflorum extract (150 mg/ml/rat/day) for 7 weeks. Body weight, adipose tissue weight (subcutaneous, epididymal, peritoneal fat pads) and serum lipids (total cholesterol and triglyceride) showed some differences among groups. The Platycodon grandiflorum feeding markedly decreased both body weight and adipose tissue weight in control group compared to H, high fat diet maintaining, group. Platycodon grandiflorum extracts significantly decreased the concentrations of serum lipids compared to H group. Fat cell numbers and sizes were significantly reduced in the oriental medicinal herb extract administrated group. Increased fatty acid binding protein (FABP) expression in high fat diet group was decreased by the dietary conversion to normal diet and the oral administration of Platycodon glandiflorum extracts. In contrast, there was no significant effect on FABP expression in the high fat maintenance group. In this study, the conversion from high fat diet to low fat or normal diet had a beneficial effect on body weight loss and serum lipid profiles. Dietary Platycodon glandiflorum extracts had an additive beneficial effect on the prevention and treatment of obesity.

참고문헌 (30)

  1. Grundy SM, Barnett JP. Metabolic and health complications of obesity. In bone RC, ed. Disease-a-month. Mosby Year Book. 36(12):643-731, 1990 
  2. Epstein LH, Wing RR, Valoski A. Childhood obesity. Pediatric Clinics of North America 32:363-379, 1985 
  3. Lee JH. Treatment of obesity. J Kor Soc Food Nutr 1(1):21-24, 1992 
  4. Segal KR, Pi-Sunny FX. Exercise and obesity. Med Clin North Am 73:217-236, 1989 
  5. Glatz JFC, Veerkamp JH. Intracellular fatty acid binding proteins. Int J Biochem 17:13-22, 1985 
  6. Mataress V, Stone RL, Waggner DW, Bernlihr DA. Intracellular fatty acid trafficking and the role of cytosolic lipid binding proteins. Prog Lip Res 28:245-272, 1989 
  7. Lee ES, Lim SS, Chung SH, Lee JS, Shin HD. The effect of the Banggihwanggitang on the biochemical changes of obese rats. Kor J Oriental Med 5(1):1-37, 1995 
  8. Reeves PG, Nielsen FH, Fahey GC. AIN-93 purified diets for laboratiry rodents final report of the American Institute of Nutrition ad hoc writing committee on the reformulation of the AIN-76A rodent. J Nutr 123:1939-1951, 1993 
  9. Oakenfull DG, Fenwick DE, Hood RL. Effects of saponins on bile acids and plasma lipids in the rat. Br J Nutr 42(2):209-216, 1979 
  10. Bass NM. The cellular fatty acid bindimg proteins : Aspects of structure, regulation and fuction. Int Rev Ctyol 111:143-184, 1988 
  11. Vidal AP, Mercedes JL, Bradford BL. Regulation of $PPAR{\gamma}$ gene expression by Nutrition and obesity in rodentes. J Clin Invest 97:2553-2561, 1996 
  12. Schoonjans K, Staels B, Auwerk J. The peroxisome pro­liferator activated receptors (PPARS) and their effects on lipid metabolism and adipocyte differentiation. Biochim Biophys Acta 26:1302, 1996 
  13. Albright AL. Stem JS. Adipose tissue. In: Encyclopedia of Sports Medicine and Science, Internet Society for Sport Science. 1998 
  14. Shoji O, Junko N, Tetsuro S, Hiroshi F. Identification of a Rat 30-kDa protein recognized by the antibodies to a recom­binant rat cataneous fatty acid binding protein as a 14-3-3 protein. J Biochem 129:213-219, 2001 
  15. Riessert J, Andreelli F, Auboeuf D, Roques M, Vallier P, Riou JP, Auwerx J, Larille M, Vidal H. Insulin acutely activated receptor-gamma in human adipocytes. Diabetes 48:699-705, 1999 
  16. Lowell BB. PPAR;an essential regulator of adipogenesis and modulator of fat cell function. Cell 99:239-242, 1999 
  17. Sidhu GS, Oakenfull DG. A mechanism for the hypocholesterol­emic activity of saponins. Br J Nutr 55(3):643-649, 1986 
  18. Ahn SH, Lee JH, Park HR, Kwon ST, Koh YS, Sohn YD, Jang YS, Chung KH. Effect of curcuminoids and natural plants extract mixture on the cardiovascular system in rats. Kor J Nutr 36(2):101-108, 2003 
  19. Bray GA. A concise review on the therapeutics of obesity. Nutrition 16(10):953-60, 2000 
  20. Joseph V, Norvert L. Medical significance of peroxisome proliferator activated receptors. Lancet 354:141-148, 1999 
  21. Matarese V, Stone RL, Waggoner DW, Bernlohr DA. Intracellular fatty acid trafficking and the role of cytosolic lipid binding proteins. Prog Lipid Res 28(4):245-72, 1989 
  22. Lee DJ, Han IK, Chung HY, Lee KR. Combination of Diet, Exercise recording and low dose fluoxetine treatment in obese women. J Kor Soc Study Obesity 2(1):1-4, 1993 
  23. Kim SY. Effects of the Feeding Platycodon grandiflorum and Codonopsis lanceolata on the Fatty Acid Composition of Serum and Liver in Rats. J Kor Soc Food Nutr 13(4):413-420, 1984 
  24. Lee HK. Obesity and its associated disease. J Kor Soc Study Obesity 1:34, 1992 
  25. Korea Society of Obesity. Clinical Obesity. Korea Medicine press, 1995 
  26. Fisher H, Silver WG. The retardation by pectin of cholesterol induced atherosclerosisin the fowl. J Atheroscl Res 6(3):292-298, 1966 
  27. Kim SY, Kim HS, Su IS, Yi HS, Kim HS, Chung SY. Effects of the Feeding Platycodon grandiflorum and Codonopsis lanceolata on the Lipid Components of Serum and Liver in Rats. J Kor Soc Food Nutr 22(5):517-523, 1993 
  28. Morrison RF, Farmer SR:lnsight into the transcriptional control of adipocyte differentiation. J Cell Biol Suppl 32:33:59-67, 1999 
  29. Council on Scientific Affairs :Treatment of obesity in adults. Am Med Assoc 260:2547-2551, 1988 
  30. Okner RK, Manning JA, Fatty acid binding protein in small intestine : Identification, isolation, and evidence for its role in cellular fatty acid transport. J Clin Invest 54:326-338, 1974 

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