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Synthesis, Analgesic, and Anti-Inflammatory Activities of [6-(3,5-Dimethyl-4-Chloropyrazole-1-yl)-3(2H)-Pyridazinon-2-yl]Acetamides 원문보기

Archives of pharmacal research : a publication of the Pharmaceutical Society of Korea, v.28 no.5, 2005년, pp.509 - 517  

Sukuroglu, Murat (Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Gazi University) ,  Caliskanergun, Burcu (Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Gazi University) ,  Unlu, Serdar (Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Gazi University) ,  Sahin, M.Fethi (Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Gazi University) ,  Kupeli, Esra (Department of Pharmacognosy, Faculty of Pharmacy, Gazi University) ,  Yesilada, Erdem (Department of Pharmacognosy, Faculty of Pharmacy, Gazi University) ,  Banoglu, Erden (Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Gazi University)

Abstract AI-Helper 아이콘AI-Helper

A series of structurally diverse amide derivatives of [6-(3,5-dimethyl-4- chloro-pyrazole-1-yl)-3(2H)-pyridazinone-2-yl]acetic acid were prepared and tested for their in vivo analgesic and anti-inflammatory activity by using p-benzoquinone-induced writhing test and carrageenan induced hind paw edema...

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  • acid show analgesic and anti-inflammatory activity, and the presence of fluroroarylpiperazine and alkylamine sb・ stituents in the amide portion might contribute to their activity. These type of compounds along with our previously published results (Banoglu et al.
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참고문헌 (28)

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