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논문 상세정보

Abstract

Flowers of Erigeron annuus L. were extracted with 80% aqueous MeOH, and the concentrated extract was partitioned with EtOAc, n-BuOH, and H$_2$O. Repeated silica gel and OD S column chromatography of the EtOAc fraction led to the isolation of a sterol, through activityguided fractionation, using ACAT inhibitory activity measurements. From the physico-chemical data, including NMR, MS, and IR, the chemical structure of the compound was determined to be an ergosterol peroxide (1), which has been isolated for the first time from this plant. This compound exhibited hACAT-1 and Lp-PLA$_2$ inhibitory effects, with inhibitory values of 51.6 ${\pm}$ 0.9 and 51 .7 ${\pm}$ 1.2%, at a treatment concentration of 0.23 mM.

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이 논문을 인용한 문헌 (6)

  1. 2006. "" 韓國藥用作物學會誌 = Korean journal of medicinal crop science, 14(5): 273~277 
  2. 2006. "" Archives of pharmacal research : a publication of the Pharmaceutical Society of Korea, 29(3): 191~194 
  3. 2007. "" Archives of pharmacal research : a publication of the Pharmaceutical Society of Korea, 30(11): 1392~1397 
  4. 2008. "" Archives of pharmacal research : a publication of the Pharmaceutical Society of Korea, 31(4): 429~437 
  5. 2010. "" Journal of microbiology and biotechnology, 20(1): 78~81 
  6. 2010. "" Journal of microbiology and biotechnology, 20(11): 1521~1523 

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