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논문 상세정보

Abstract

The flower of Campsis grandiflora K. Schum. Was extracted with 80% aqueous MeOH, and the concentrated extract was partitioned with EtOAc, n-BuOH and H$_2$O. From the EtO Ac fraction, seven triterpenoids were isolated through the repeated silica gel, ODS column chromatographies and preparative HPLC. From the result of physico- chemical data including NMR, MS and IR, the chemical structures of the compounds were determined as 3${\beta}$-hydroxyolean-12-en-28-oic acid (oleanolic acid, 1), 3${\beta}$-hydroxyurs-12-en-28-oic acid (ursolic acid, 2), 3${\beta}$-hydroxyurs-12-en-28-al (ursolic aldehyde, 3), 2${\alpha}$,3${\beta}$-dihydroxyolean-12-en-28-oic acid (maslinic acid, 4), 2${\alpha}$,3${\beta}$-dihydroxyurs-12-en-28-oic acid (corosolic acid, 5), 3${\beta}$,23-dihydroxyurs-12- en-28-oic acid (23-hydroxyursolic acid ,6) and 2${\alpha}$,3${\beta}$,23-trihydroxyolean-12-en-28- oic acid (arjunolic acid, 7). These teriterpenoids were isolated for the first time from this plant. Also, compounds 4, 5, 6, and 7 revealed relatively high hACAT-1 inhibitory activity with the value of 46.2${\pm}$1.1, 46.7${\pm}$0.9, 41.5${\pm}$1.3 and 60.8${\pm}$1.1% at the concentration of 100${\mu}$g/mL, respectively.

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이 논문을 인용한 문헌 (5)

  1. 2007. "" Bulletin of the Korean Chemical Society, 28(10): 1851~1853 
  2. Lee, Dae-Young ; Jeong, Tae-Sook ; Lyu, Ha-Na ; Bang, Myun-Ho ; Hong, Yoon-Hee ; Lee, Youn-Hyung ; Baek, Nam-In 2008. "Screening for Human ACAT-1 and ACAT-2 Inhibitory Activity of Edible Plant Extracts" 韓國藥用作物學會誌 = Korean journal of medicinal crop science, 16(5): 341~348 
  3. 2009. "" Natural product sciences, 15(2): 90~95 
  4. 2009. "" Natural product sciences, 15(3): 151~155 
  5. 2010. "" Journal of the Korean Society for Applied Biological Chemistry, 53(1): 97~100 

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