[논문]Preparation of Controlled Release Spheronized Beads by a Simple Extrusion and Modified Spheronization Process

Lee, Si-Beum; Kim, Min-Soo; Jun, Seoung-Wook; Park, Jeong-Sook; Hwang, Sung-Joo

doi:10.1007/bf02977768

Preparation of Controlled Release Spheronized Beads by a Simple Extrusion and Modified Spheronization Process 원문보기

Archives of pharmacal research : a publication of the Pharmaceutical Society of Korea, v.28 no.5, 2005년, pp.619 - 625

Lee, Si-Beum (National Research Lab of Pharmaceutical Technology, College of Pharmacy, Chungnam National University) , Kim, Min-Soo (National Research Lab of Pharmaceutical Technology, College of Pharmacy, Chungnam National University) , Jun, Seoung-Wook (National Research Lab of Pharmaceutical Technology, College of Pharmacy, Chungnam National University) , Park, Jeong-Sook (National Research Lab of Pharmaceutical Technology, College of Pharmacy, Chungnam National University) , Hwang, Sung-Joo (National Research Lab of Pharmaceutical Technology, College of Pharmacy, Chungnam National University)

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Beads loaded with the water-soluble drug, phenylpropanolamine HCl (PPA), were prepared using an extruder and double arm counter-rotating roller modified from a traditional pill machine. The mean diameter of the cylindrical rod-like extrudate from the ram extruder was 3 mm; that of the uncoated bead after cutting and spheronization by the modified double arm counter-rotating roller was 3.26~3.28 mm. Although the surface of the beads was moderately rough and irregular, some exhibited hump-shaped protrusions, the sphericity was acceptable (roundness 1.15) and adequate for the subsequent coating process. An increase in mean diameter of the coated beads and improvements in friability and sphericity were observed in proportion to the amount of coating material applied (ethylcellulose or Eudragit？？ RS 100). It was also found that the release rate of PPA from the coated beads could be controlled by the amount and type of coating materials applied or with the incorporation of Eudragit ？？ RS 100 into the core matrix. Further modifications to the double arm counter-rotating roller, including adjustment of the rotation speed and distance between the rollers, would yield smaller uncoated beads with improved roundness and surface roughness. In conclusion , the present method could be potentially applied to prepare controlled release drug delivery beads or pellet dosage forms.

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문제 정의

The do나ble arm counter-rotating roller modified for this study had bowl-shaped furrows on the roller surfaces, such that the coming together of these half-spheres on two separate rollers would make a hollow of the desired size. This work was essentially a feasibility study for the prod니ction of beads smaller than those currently man니factured by extrusion and spheronization, with the aim of improving the controlled-release pellet drug delivery system.

제안 방법

A laboratory-scale pan spray coating system was used in this study. The coating process was initiated when the coating pan had achieved the desired temperature (50°C).
In this study, beads were prepared with a laboratory ram extruder and modified double arm counter-rotating roller (Fig. 1). A wet mass, containing known proportions of PPA, lactose, corn starch, PVP K-30 and magnesium stearate, was fed through a hopp으!" into the ram extiuder.
4 kJ/ min, Changsung Industry, Korea) was used for pellet ization and spheronization. Preparation and evaluation of the beads was accomplished with a UV너 201 spectropho tometer (Shimadz니 Cooperation, Japan), VK-7000 dissolu tion testing station, VK-750d heater and circulator (VanKel Industries Inc., NC, U.S.A.) and a laboratory pan spray coating system (Han S나ng Engineering, Korea).

참고문헌 (17)

Barrau, J. P., Bataille, B., and Jacob, M., The influence of spheronizer load in extrusion/spheronization. Pharm. Tech. Int., 66, 68-70 (1993)
Bodmeier, R., Tableting of coated pellets. Eur. J. Pharm. Biopharm., 43, 1-8 (1997)

상세보기
Christian, S. and Peter, K., Comparison between a twin-screw extruder and a rotatory ring die press. Part : influence of process variables. Eur. J. Pharm. Biopharm., 45, 173-179 (1998)

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David, F. E., Extrusion-spheronization as a granulation technique in Handbook of Pharmaceutical Granulation Technology; Dilip, M. P., Marcel Dekker, Inc.: New York, 333- 368 (1997)
Gandhi, R., Kaul, C. L., and Panchagnula, R., Extrusion and spheronization in the development of oral controlled-release dosage forms. PSTT, 2, 160-170 (1999)
Hofman, P. G., Pill and pill-making, available online, http:// www.rpsgb.org.uk /members/pdfs/mussheet07.pdf, (2002)
Jee, U. K., Hwang, S. J., Park, J. K., Park, K. L., Moon, Y. G., Lee, S., and Kwon, Y. J., PCT Int. Appl. WO 2004/050064 A1, 17 Jun 2004, Method of manufacturing controlled release formulation using pelletizer, (2004)
MacRitchie, K. A., Newton, J. M., and Rowe, R. C., The evaluation of the rheological properties of lactose/microcrystalline cellulose and water mixtures by controlled stress rheometry and the relationship to the production of spherical pellets by extrusion/spheronization. Eur. J. Pharm. Sci., 17, 43-50 (2002)

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Neau, S. H., Chow, M. Y., Hileman, G. A., Durrani, M. J., Gheyas, F., and Evans, B. A., Formulation and process considerations for beads containing Carbopol $^{\circledR}$ 974P, NF resin made by extrusion-spheronization. Int. J. Pharm., 199, 129-140 (2000)

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Otsuka, M., Gao, J., and Matsuda, Y., Effect of amount of added water during extrusion-spheronization process on pharmaceutical properties of granules. Drug Dev. Ind. Pharm., 20, 2977-2992 (1994)

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Pearnchob, N. and Bodmeier, R., Coating of pellets with micronized ethylcellulose particles by a dry power coating technique. Int. J. Pharm., 268, 1-11 (2003)

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PharmaEquipment, Pill forming machines catalogue, available online, http://pharmaequip mentcanada.com/equipment/pill_forming, (2001)
Ramarao, C. and Bhagwan, D. R., Rheological characterization of diltiazem HCl/cellulose wet masses using a mixer torque rheometer. Int. J. Pharm., 175, 47-59 (1998)

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Rashid, H. A., Heinamaki, J., Antikainen, O., and Yliruusi, J., Influence of the centrifugal granulating process on the properties of layered pellets. Eur. J. Pharm. Biopharm., 51, 227-234 (2001)

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Sousa, J. J., Sousa, A., Podczeck, F., and Newton, J. M., Factors influencing the physical characteristics of pellets obtained by extrusion-spheronization. Int. J. Pharm., 232, 91- 106 (2002)

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Vervaet, C., Baert, L., and Remon, J. P., Extrusion-spheronisation: a literature review. Int. J. Pharm., 116, 131-146 (1995)

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Young, C. R., Koleng, J. J., and McGinity, J. W., Production of spherical pellets by a hot-melt extrusion and spheronization process. Int. J. Pharm., 242, 87-92 (2002)

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Preparation of Controlled Release Spheronized Beads by a Simple Extrusion and Modified Spheronization Process 원문보기

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Preparation of Controlled Release Spheronized Beads by a Simple Extrusion and Modified Spheronization Process 원문보기

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