$\require{mediawiki-texvc}$
  • 검색어에 아래의 연산자를 사용하시면 더 정확한 검색결과를 얻을 수 있습니다.
  • 검색연산자
검색연산자 기능 검색시 예
() 우선순위가 가장 높은 연산자 예1) (나노 (기계 | machine))
공백 두 개의 검색어(식)을 모두 포함하고 있는 문서 검색 예1) (나노 기계)
예2) 나노 장영실
| 두 개의 검색어(식) 중 하나 이상 포함하고 있는 문서 검색 예1) (줄기세포 | 면역)
예2) 줄기세포 | 장영실
! NOT 이후에 있는 검색어가 포함된 문서는 제외 예1) (황금 !백금)
예2) !image
* 검색어의 *란에 0개 이상의 임의의 문자가 포함된 문서 검색 예) semi*
"" 따옴표 내의 구문과 완전히 일치하는 문서만 검색 예) "Transform and Quantization"

과학기술 지식인프라 ScienceON

상세검색 다국어 입력
도움말도움말
쳇봇 이모티콘
안녕하세요!
ScienceON 챗봇입니다.
궁금한 것은 저에게 물어봐주세요.

논문 상세정보

MyON담기
내보내기

Construction of Comprehensive Metabolic Network for Glycolysis with Regulation Mechanisms and Effectors

Journal of microbiology and biotechnology v.15 no.1 , 2005년, pp.161 - 174  
JIN, JONG-HWA (Department of Chemical Engineering, Kwangwoon University ) ;  JUNG, UI-SUB ( Department of Chemical Engineering, Kwangwoon University ) ;  JAE, WOOK-NAM ( School of Chemical Engineering, Seoul National University ) ;  IN, YONG-HO ( Bioinformatix Inc., Eighth Floor, Sung Woo Bldg. ) ;  LEE, SANG-YUP ( Department of Chemical and Biomolecular Engineering, Korea Advanced Institute of Science and Technology ) ;  LEE, DOHE-ON ( Department of Biosystems, Korea Advanced Institute of Science and Technology ) ;  LEE, JIN-WON ( Department of Chemical Engineering, Kwangwoon University)
Abstract

Abstract Glycolysis has a main function to provide ATP and precursor metabolites for biomass production. Although glycolysis is one of the most important pathways in cellular metabolism, the details of its regulation mechanism and regulating chemicals are not well known yet. The regulation of the glycolytic pathway is very robust to allow for large fluxes at almost constant metabolite levels in spite of changing environmental conditions and many reaction effectors like inhibitors, activating compounds, cofactors, and related metal ions. These changing environmental conditions and metabolic reaction effectors were focused on to understand their roles in the metabolic networks. In this study, we have investigated for construction of the regulatory map of the glycolytic metabolic network and tried to collect all the effectors as much as possible which might affect the glycolysis metabolic pathway. Using the results of this study, it is expected that a complex metabolic situation can be more precisely analyzed and simulated by using available programs and appropriate kinetic data.

주제어

#Glycolysis   #metabolic pathway   #inhibitors   #activating  

저자의 다른 논문

진종화(3) Lee, Sang-Yup(113) Lee, Doheon(2)

참고문헌 (31)

  1. Green, F. C. and R. E. Feeney. 1970. Properties of muscle glyceraldehyde-3-phosphate dehydrogenase from the coldadapted antarctic fish Dissostichus mawsoni. Biochim. Biophvs. Acta 220: 430- 442 
  2. http://www.biocarta.com/genes/allPathways.asp 
  3. http://www.genome.ad.jp/kegg/metabolism.html 
  4. http://www.gwu.edu/-mpb/ 
  5. http://www.informatics.jax.org/searches 
  6. http://www.tcd.ie/Biochemistry/IUBMB-Nicholson/ 
  7. Hynne, F., P. G. Sorensen, and T. Moller. 1993. Current and eigenvector analysis of chemical reaction networks at Hopf bifurcations. J. Chem. Phys. 98: 211- 218 
  8. Lee, C. S. and W. J. O'Sullivan. 1975. Properties and mechanism of human erythrocyte phosphoglycerate kinase. J. Biol. Chem. 250: 1275- 1281 
  9. Montignv, C. and J. Sygusch. 1996. Functional characterization of an extreme thermophilic class II fructose 1,6-bisphosphate aldolase. Eur. J. Biochem. 241: 243- 248 
  10. Stocchi, V. M., F. C. Magnani, and G. Fomaini. 1982. Multiple forms of human red blood cell hexokinase: Preparation, characterization, and age dependence. J. Biol. Chem. 257: 2357- 2364 
  11. Flynn, I. W. and I. B. R. Bowman. 1980. Purification and characterization of pyruvate kinase from Trypanosoma brucei. Arch. Biochem. Biophys. 200: 401- 409 
  12. http://www.empproject.com/ 
  13. http://www.brenda.uni-koeln.de/ 
  14. http://biocyc.org/ 
  15. Lee, S. Y., S. H. Hong, and S. Y. Moo. 2002. In silico metabolic pathway analysis and design: Succinic acid production by metabolically engineered Escherichia coli an example. Genome Informatics 13: 214- 223 
  16. Goldberg, R. N. 1999. Thermodynamics of enzymecatalyzed reaction: Part 6. Update. J. Phys. Chem. 28: 931-965 
  17. Sakai, H., K. Suzuki, and K. lmahori. 1986. Purification and properties of pyruvate kinase from Bacillus stearothennophilus. J. Biochem. 99: 1157- 1167 
  18. Nakagawa, T. and F. Nagayama. 1991. Enzymatic properties of enolase from fish muscle. Comp. Biochem. Physiol. 98: 355- 359 
  19. Thomas, D. A. 1981. Partial purification and characterization of glucose-6-phosphate isomerase from Dictyostelium discoideum. J. Gen. Microbiol. 124: 403- 407 
  20. Fell, D. 1997. Understanding the Control of Metabolism, pp. 197 - 219. Portland Press Ltd., London, U.K 
  21. Fujita, S. C., T. Oshima, and K. Imahori. 1976. Purification and properties of D-glyceraldehyde-3-phosphate dehydrogenase from an extreme thermophile, Thermus thermophilus strain HB8. Eur. J. Biochem. 64: 57- 68 
  22. Hynne, F., S. Dano, and P. G. Sorensen. 2001. Full-scale model of glycolysis in Saccharomyces cerevisiae. J. Biol. Chem. 94: 121- 163 
  23. Cornpbell, N. A., L. G. Mitchell, and J. B. Reece. 1999. Biology, pp. 518- 519. 3rd Ed. San Francisco, U.S.A 
  24. Stephanopoulos, G. N., A. Aristidou, and J. Nielsen. 1998. Metabolic Engineering: Principles and Methodologies, pp. 38- 45. Academic Press, San Diego, U.S.A 
  25. Babul, J. D., C. M. Kretschmer, and D. G. Fraenkel. 1993. Glucose metabolism in Escherichia coli and the effect of increased amount of aldolase. Biochemistry 32: 4685- 4692 
  26. Goldberg, R. N. and Y. B. Tewari. 1995. Thermodynamics of enzyme-catalyzed reactions: Part 5. Isomerases and ligases. J. Phys. Chem. 24: 1765- 1801 
  27. Goldberg, R. N., and Y. B. Tewari. 1995. Thermodynamics of enzyme-catalyzed reactions: Part 1. Lyases. J. Phys. Chem. 24: 1669- 1698 
  28. Marcel, H. N., J. C. Hoefnagel, D. M. Starrenburg, M. K. Jeroen Hugenholtz, V. R. Iris, V. W. Hans, and L. S. Jacky. 2002. Metabolic engineering of lactic acid bacteria the combined approach: Kinetic modeling metabolic control and experimental analysis. Microhiology 148: 1003- 1013 
  29. Goldberg, R. N., Y. B. Tewari, D. K. Bell, and J. A. Fazio. 1993. Thermodynamics of enzyme-catalyzed reactons: Part l. Oxidoreductases. J. Phys. Chem. 22: 505- 582 
  30. Pelzer, R. B., S. Wiegand, and C. Scharrenberger. 1994. Plastid class and cytosol class II aldolase of Euglena gracilis. Plant Physiol.106: 1137-1144 
  31. Kombrink, E. 1982. Chloroplast phosphofructokinase in the green alga, Dunaliella marina: Partial purification and kinetic and regulatory properties. Arch. Biochern. Biophys. 213: 602-619 

이 논문을 인용한 문헌 (5)

  1. Jung, Ui-Sub ; Lee, Hye-Won ; Lee, Jin-Won 2005. "Study of in Silico Simulation Method for Dynamic Network Model in Lactic Acid Bacteria" 제어·자동화·시스템공학 논문지 = Journal of control, automation and systems engineering, 11(10): 823~829 
  2. 2005. "" Biotechnology and bioprocess engineering, 10(5): 400~407 
  3. 2006. "" Journal of microbiology and biotechnology, 16(5): 748~756 
  4. 2007. "" Journal of microbiology and biotechnology, 17(11): 1789~1796 
  5. 2007. "" Journal of microbiology and biotechnology, 17(3): 496~510 

원문보기

원문 PDF 다운로드

  • ScienceON :
  • KCI :

원문 URL 링크

원문 PDF 파일 및 링크정보가 존재하지 않을 경우 KISTI DDS 시스템에서 제공하는 원문복사서비스를 사용할 수 있습니다. (원문복사서비스 안내 바로 가기)

상세조회 0건 원문조회 0건

DOI 인용 스타일