$\require{mediawiki-texvc}$

연합인증

연합인증 가입 기관의 연구자들은 소속기관의 인증정보(ID와 암호)를 이용해 다른 대학, 연구기관, 서비스 공급자의 다양한 온라인 자원과 연구 데이터를 이용할 수 있습니다.

이는 여행자가 자국에서 발행 받은 여권으로 세계 각국을 자유롭게 여행할 수 있는 것과 같습니다.

연합인증으로 이용이 가능한 서비스는 NTIS, DataON, Edison, Kafe, Webinar 등이 있습니다.

한번의 인증절차만으로 연합인증 가입 서비스에 추가 로그인 없이 이용이 가능합니다.

다만, 연합인증을 위해서는 최초 1회만 인증 절차가 필요합니다. (회원이 아닐 경우 회원 가입이 필요합니다.)

연합인증 절차는 다음과 같습니다.

최초이용시에는
ScienceON에 로그인 → 연합인증 서비스 접속 → 로그인 (본인 확인 또는 회원가입) → 서비스 이용

그 이후에는
ScienceON 로그인 → 연합인증 서비스 접속 → 서비스 이용

연합인증을 활용하시면 KISTI가 제공하는 다양한 서비스를 편리하게 이용하실 수 있습니다.

Sensitization of Vanilloid Receptor Involves an Increase in the Phosphorylated Form of the Channel

Archives of pharmacal research : a publication of the Pharmaceutical Society of Korea, v.28 no.4, 2005년, pp.405 - 412  

Lee Soon-Youl (Department of Genomic Engineering, Genetic Informatics Center, GRRC) ,  Lee Jae-Hag (Department of Food and Nutrition, Seoil College) ,  Kang Kwon Kyoo (Department of Horticulture, Hankyong National University) ,  Hwang Sue-Yun (Graduate School of Bio & Information Technology, Hankyong National University) ,  Choi Kang Duk (Graduate School of Bio & Information Technology, Hankyong National University) ,  Oh Uhtaek (The Sensory Research Center, National Creative Research Initiatives, College of Pharmacy, Seoul National University)

Abstract AI-Helper 아이콘AI-Helper

A vanilloid receptor (VR1, now known as TRPV1) is an ion channel activated by vanilloids, including capsaicin (CAP) and resiniferatoxin (RTX), which are pungent ingredients of plants. Putative endogenous activators (anandamide and metabolites of arachidonic acid) are weak activators of VR1 compared ...

주제어

AI 본문요약
AI-Helper 아이콘 AI-Helper

* AI 자동 식별 결과로 적합하지 않은 문장이 있을 수 있으니, 이용에 유의하시기 바랍니다.

가설 설정

  • Therefore, we used 10 mM of PMA, at which small portions of DRG showed CAP activity in order to activate the VR1 current. This study of in vivo phosphorylation supports the idea that PMA does not activate the channel by direct interaction, but rather that PMA sensitize the channel by activating PKC to phosphorylate the channel. It is also possible that PMA activates the channel in a PKC-independent manner, as accumulating lines of evidence indicate that in addition to activating PKC, PMA also produces some regulatory effects in a PKC-independent manner (Samuvel et al.
본문요약 정보가 도움이 되었나요?

참고문헌 (40)

  1. Amos, S., Martin, P. M., Polar, G. A., Parsons, S. J., and Hussaini, I. M., Phorbol 12-myristate 13-acetate induces epidermal growth factor receptor transactivation via protein kinase C{delta}/c-Src pathways in glioblastoma cells. J. Biol. Chem., 280, 7729-7738 (2005) 

  2. Caterina, M. J., Schumacher, M. A., Tominaga, M., Rosen, T. A., Levine, J. D., and Julius, D., The capsaicin receptor: a heat-activated ion channel in the pain pathway. Nature, 389, 816-824 (1997) 

  3. Caterina, M. J., Leffler, A., Malmberg, A. B., Martin, W. J., Trafton, J., Petersen-Zeitz, K. R., Koltzenburg, M., Basbaum, A. I., and and Julius, D., Impaired nociception and pain sensation in mice lacking the capsaicin receptor. Science, 288, 306-313 (2000) 

  4. Cesare, P., Moriondo, A., Vellani, V., and McNaughton, P. A., Ion channels gated by heat. Proc. Natl. Acad. Sci. U.S.A., 96, 7658-63 (1999) 

  5. Cesare, P. and McNaughton, P., A novel heat-activated current in nociceptive neurons and its sensitization by bradykinin. Proc. Natl. Acad. Sci. U.S.A., 93, 15435-15439 (1996) 

  6. Cheng, S. H., Rich, D. P., Marshall, J., Gregory, R. J., Welsh, M. J., and Smith, A. E., Phosphorylation of the R domain by cAMP-dependent protein kinase regulates the CFTR chloride channel. Cell, 66, 1027-1036 (1991) 

  7. Chuang, H. H., Prescott, E. D., Kong, H., Shields, S., Jordt, S. E., Basbaum, A. I., Chao, M. V., and Julius, D., Bradykinin and nerve growth factor release the capsaicin receptor from PtdIns(4,5) P2-mediated inhibition. Nature, 411, 957-962 (2001) 

  8. Cortright, D. N. and Szallasi, A., Biochemical pharmacology of the vanilloid receptor TRPV1. An update. Eur. J. Biochem., 271, 1814-1819 (2004) 

  9. Davies, S. P., Reddy, H., Caivano, M., and Cohen, P., Specificity and mechanism of action of some commonly used protein kinase inhibitors. Biochem. J., 351 (part 1), 95-105 (2000) 

  10. Davis, J. B., Gray, J., Gunthorpe, M. J., Hatcher, J. P., Davey, P. T., Overend, P., Harries, M. H., Latcham, J., Clapham, C., Atkinson, K., Hughes, S. A., Rance, K., Grau, E., Harper, A. J., Pugh, P. L., Rogers, D. C., Bingham, S., Randall, A., and Sheardown, S. A., Vanilloid receptor-1 is essential for inflammatory thermal hyperalgesia. Nature, 405, 183-187 (2000) 

  11. De Petrocellis, L., Harrison, S., Bisogno, T., Tognetto, M., Brandi, I., Smith, G. D., Creminon, C., Davis, J. B., Geppetti, P., and Di Marzo, V. J., The vanilloid receptor (VR1)- mediated effects of anandamide are potently enhanced by the cAMP-dependent protein kinase. Neurochem., 77, 1660- 1663 (2001) 

  12. Di Marzo, V., Bisogno, T., and De Petrocellis, L., Anandamide: some like it hot. Trends Pharmacol. Sci., 22, 346-349 (2001) 

  13. Docherty, R. J., Yeats, J. C., and Piper, A. S., Inhibition of calcineurin inhibits the desensitization of capsaicin-evoked currents in cultured dorsal root ganglion neurones from adult rats. Br. J. Pharmacol., 121, 1461-1467 (1996) 

  14. Hong, S. and Wiley, J. W., Early painful diabetic neuropathy is associated with differential changes in the expression and function of vanilloid receptor 1. J. Biol. Chem., 280, 618-627 (2004) 

  15. Huang, S. M., Bisogno, T., Trevisani, M., Al-Hayani, A., De Petrocellis, L., Fezza, F., Tognetto, M., Petros, T. J., Krey, J. F., Chu, C. J., Miller, J. D., Davies, S. N., Geppetti, P., Walker, J. M., and Di Marzo, V., An endogenous capsaicin-like substance with high potency at recombinant and native vanilloid VR1 receptors. Proc. Natl. Acad. Sci. U.S.A., 99, 8400-8405 (2002) 

  16. Hwang, S. W., Cho, H., Kwak, J., Lee, S. Y., Kang, C. J., Jung, J., Cho, S., Min, K. H., Suh, Y. G., Kim, D., and Oh, U., Direct activation of capsaicin receptors by products of lipoxygenases: endogenous capsaicin-like substances. Proc. Natl. Acad. Sci. U. S. A., 97,6155-6160 (2000) 

  17. Jung, J., Shin, J. S., Lee, S. Y., Hwang, S. W., Koo, J., Cho, H., and Oh, U., Phosphorylation of vanilloid receptor 1 by $Ca^{2+}$ / calmodulin-dependent kinase II regulates its vanilloid binding. J. Biol. Chem., 279, 7048-7054 (2004) 

  18. Khasar, S. G., Lin, Y. H., Martin, A., Dadgar, J., McMahon, T., Wang, D., Hundle, B., Aley, K. O., Isenberg, W., McCarter, G., Green, P. G., Hodge, C. W., Levine, J. D., and Messing, R. O., A novel nociceptor signaling pathway revealed in protein kinase C epsilon mutant mice. Neuron, 24, 253-260 (1999) 

  19. Lazar, J., Szabo, T., Marincsak, R., Kovacs, L., Blumberg, P. M., and Biro, T., Sensitization of recombinant vanilloid receptor-1 by various neurotrophic factors. Life Sci., 75, 153-163 (2004) 

  20. Nakamura, J., Suda, T., Ogawa, Y., Takeo, T., Suga, S., and Wakui, M., Protein Kinase C-dependent and ? independent inhibition of $Ca^{2+}$ influx by phorbol ester in rat pancreatic $\beta$ -cells. Cell Signal, 13, 199-205 (2001) 

  21. Numazaki, M., Tominaga, T., Toyooka, H., and Tominaga, M., Direct phosphorylation of capsaicin receptor VR1 by protein kinase Cepsilon and identification of two target serine residues. J. Biol. Chem., 277, 13375-13382 (2002) 

  22. Oh, U., Hwang, S. W., and Kim, D., Capsaicin activates a nonselective cation channel in cultured neonatal rat dorsal root ganglion neurons. J. Neurosci., 16, 1659-1667 (1996) 

  23. Olah, Z., Karai, L., and Iadarola, M. J., Protein kinase C alpha is required for vanilloid receptor 1 activation. Evidence for multiple signaling pathways. J. Biol. Chem., 277, 35752- 35759 (2002) 

  24. Olah, Z., Karai, L., and Iadarola, M. J., Anandamide activates vanilloid receptor 1 (VR1) at acidic pH in dorsal root ganglia neurons and cells ectopically expressing VR1. J. Biol. Chem., 276, 31163-31170 (2001) 

  25. Premkumar, L. S. Interaction between vanilloid receptors and purinergic metabotropic receptors: pain perception and beyond. Proc. Natl. Acad. Sci. U.S.A., 98, 6537-6539 (2001) 

  26. Premkumar, L. S. and Ahern, G. P., Induction of vanilloid receptor channel activity by protein kinase C. Nature, 408, 985-990 (2000) 

  27. Rathee, P. K., Distler, C., Obreja, O., Neuhuber, W., Wang, G. K., Wang, S. Y., Nau, C., and Kress, M., PKA/AKAP/VR-1 module: A common link of Gs-mediated signaling to thermal hyperalgesia. J. Neurosci., 22, 4740-4745 (2002) 

  28. Roberts, N. A., Marber, M. S., and Avkiran, M., Specificity of action of bisindolylmaleimide protein kinase C inhibitors: do they inhibit the 70 kDa ribosomal S6 kinase in cardiac myocytes? Biochem. Pharmacol., 68, 1923-1928 (2004) 

  29. Samuvel, D. J., Jayanthi, L. D., Bhat, N. R., and Ramamoorthy, S., A role for p38 mitogen-activated protein kinase in the regulation of the serotonin transporter: evidence for distinct cellular mechanisms involved in transporter surface expression. J. Neurosci., 25, 29-41 (2005) 

  30. Shin, J., Cho, H., Hwang, S. W., Jung, J., Shin, C. Y., Lee, S. Y., Kim, S. H., Lee, M. G., Choi, Y. H., Kim, J., Haber, N. A., Reichling, D. B., Khasar, S., Levine, J. D., and Oh, U., Bradykinin-12-lipoxygenase-VR1 signaling pathway for inflammatory hyperalgesia. Proc. Natl. Acad. Sci. U.S.A., 99, 10150-10155 (2002) 

  31. Smart, D., Gunthorpe, M. J., Jerman, J. C., Nasir, S., Gray, J., Muir, A. I., Chambers, J. K., Randall, A. D., and Davis, J. B., The endogenous lipid anandamide is a full agonist at the human vanilloid receptor (hVR1). Br. J. Pharmacol., 129, 227-230 (2000) 

  32. Smith, J. A., Davis, C. L., and Burgess, G. M., Prostaglandin E2- induced sensitization of bradykinin-evoked responses in rat dorsal root ganglion neurons is mediated by cAMPdependent protein kinase A. Eur. J. Neurosci., 12, 3250-3258 (2000) 

  33. Szolcsanyi, J., Anandamide and the question of its functional role for activation of capsaicin receptors. Trends. Pharmacol. Sci., 21, 203-204 (2000) 

  34. Toullec, D., Pianetti, P., Coste, H., Bellevergue, P., Grand- Perret, T., Ajakane, M., Baudet, V., Boissin, P., Boursier, E., and Loriolle, F., The bisindolylmaleimide GF 109203X is a potent and selective inhibitor of protein kinase C. J. Biol. Chem., 266, 15771-15781 (1991) 

  35. Vellani, V., Mapplebeck, S., Moriondo, A., Davis, J. B., and McNaughton, P. A., Protein kinase C activation potentiates gating of the vanilloid receptor VR1 by capsaicin, protons, heat and anandamide. J. Physiol., 534, 813-825 (2001) 

  36. Wang, Y., Kedei, N., Wang, M., Wang, Q. J., Huppler, A., Toth, A., Tran, R., and Blumberg, P. M., Interaction between PKCmu and the vanilloid receptor type 1. J. Biol. Chem., 279, 53674-53682 (2004) 

  37. Welch, J. M., Simon, S. A., and Reinhart, P. H., The activation mechanism of rat vanilloid receptor 1 by capsaicin involves the pore domain and differs from the activation by either acid or heat. Proc. Natl. Acad. Sci. U.S.A., 97, 13889-13894 (2000) 

  38. Xu, F., Satoh, E., and Iijima, T., Protein kinase C-mediated $Ca^{2+}$ entry in HEK 293 cells transiently expressing human TRPV4. Br. J. Pharmacol., 140, 413-21 (2003) 

  39. Zygmunt, P. M., Andersson, D. A., and Hogestatt, E. D., Delta 9- tetrahydrocannabinol and cannabinol activate capsaicinsensitive sensory nerves via a CB1 and CB2 cannabinoid receptor-independent mechanism. J. Neurosci., 22, 4720- 4727 (2002) 

  40. Zygmunt, P. M., Petersson, J., Andersson, D. A., Chuang, H., Sorgard, M., Di Marzo, V., Julius, D., and Hogestatt, E. D., Vanilloid receptors on sensory nerves mediate the vasodilator action of anandamide. Nature, 400, 452-457 (1999) 

관련 콘텐츠

오픈액세스(OA) 유형

FREE

Free Access. 출판사/학술단체 등이 허락한 무료 공개 사이트를 통해 자유로운 이용이 가능한 논문

섹션별 컨텐츠 바로가기

AI-Helper ※ AI-Helper는 오픈소스 모델을 사용합니다.

AI-Helper 아이콘
AI-Helper
안녕하세요, AI-Helper입니다. 좌측 "선택된 텍스트"에서 텍스트를 선택하여 요약, 번역, 용어설명을 실행하세요.
※ AI-Helper는 부적절한 답변을 할 수 있습니다.

선택된 텍스트