$\require{mediawiki-texvc}$
  • 검색어에 아래의 연산자를 사용하시면 더 정확한 검색결과를 얻을 수 있습니다.
  • 검색연산자
검색연산자 기능 검색시 예
() 우선순위가 가장 높은 연산자 예1) (나노 (기계 | machine))
공백 두 개의 검색어(식)을 모두 포함하고 있는 문서 검색 예1) (나노 기계)
예2) 나노 장영실
| 두 개의 검색어(식) 중 하나 이상 포함하고 있는 문서 검색 예1) (줄기세포 | 면역)
예2) 줄기세포 | 장영실
! NOT 이후에 있는 검색어가 포함된 문서는 제외 예1) (황금 !백금)
예2) !image
* 검색어의 *란에 0개 이상의 임의의 문자가 포함된 문서 검색 예) semi*
"" 따옴표 내의 구문과 완전히 일치하는 문서만 검색 예) "Transform and Quantization"
쳇봇 이모티콘
안녕하세요!
ScienceON 챗봇입니다.
궁금한 것은 저에게 물어봐주세요.

논문 상세정보

Abstract

The purpose of the present study was to develop a standard protocol for imidapril hydrochloride bioequivalence testing. For this reason, a specific LC-MS method was developed and validated for the determination of imidapril in human plasma. A solid-phase extraction cartridge, $Sep-pak^{R}$ C18, was used to extract imidapril and ramipril (an internal standard) from deproteinized plasma. The compounds were separated using a XTerra $MS^{R}$?C18 column ($3.5 {\mu}m, 2.1\times150 mm$) and $acetonitrile-0.1\%$ formic acid (67:33, v/v) adjusted to pH 2.4 by 2 mmol/L ammonium formic acid, as mobile phase at 0.3 mL/min. Imidapril was detected as m/z 406 at a retention time of ca. 2.3 min, and ramipril as m/z 417 at ca. 3.6 min. The described method showed acceptable specificity, linearity from 0.5 to 100 ng/mL, precision (expressed as a relative standard deviation of less than $15\%$), accuracy, and stability. The plasma concentration-versus-time curves of eight healthy male volunteers administered a single dose of imidapril (10 mg), gave an $AUC_{12hr}$ of imidapril of $121.48\pm35.81 ng mL^{-1} h$, and $C_{max} and T_{max}$ values of $32.59\pm9.76 ng/mL and 1.75\pm0.27 h$. The developed method should be useful for the determination of imidapril in plasma with sufficient sensitivity and specificity in bioequivalence study.

저자의 다른 논문

참고문헌 (10)

  1. Bonazzi, D., Gotti, R., Andrisano, V., and Cavrini, V., Analysis of ACE inhibitors in pharmaceutical dosage forms by derivative UV spectroscopy and liquid chromatography (HPLC). J. Pharm. Biomed. Anal., 16, 431-438 (1997) 
  2. Tanaka, H. Y., Yoneyama, Sugawara, M., Umeda, I., and Ohta, Y., Enzyme immunoassay discrimination of a new angiotensin-converting enzyme (ACE) inhibitor, cilazapril, and its active metabolite. J. Pharmaceutical Science, 76, 224 -227 (1987) 
  3. Belal, F., Al -Zaagi, I. A., Gadkariem, E. A., and Abounassif, M. A., A stability-indicating LC method for the simultaneous determination of ramipril and hydrochlorothiazide in dosage forms. J. Pharm. Biomed. Anal., 24, 335-342 (2001) 
  4. Harder, S., Thurmann, P. A., and Ungethum, W., Single dose and steady state pharmacokinetics and pharmacodynamics of the ACE-inhibitor imidapril in hypertensive patients. Br. J. Clin. Pharmacol., 45, 377-380 (1998) 
  5. Lee, Y. J., Jung, S. J., and Shim, C. K., K-BE Test 2002 for window, Version 1.2.1. (2002) 
  6. Yamanaka, K., Takehara, N., Murata, K., Banno, K., and Sato, T., Pharmacokinetic and pharmacodynamic study of imidaprilat, and active metabolite of imidapril, a new angiotensincoverting enzyme inhibitor, in spontaneously hypertensive rats. J. Pharm. Biomed. Anal., 15, 1851-1859 (1997) 
  7. Tipnis, V. and Rakhit, A., Determination of pentopril, an angiotensin converting enzyme inhibitor, and its active metabolite in urine. J. Chromatogr.:Biomedical Application, 345, 396-401 (1985) 
  8. Yamanaka, K., Morikawa, S., Murata, K., Bano, K., Sato, T., Takai, T., Suzuki, T., Mizobe, M., Ito, M., and Ishibashi, K., Radioimmunoassay for imidapril, a new angiotensinconverting enzyme inhibitor, and imidaprilat, its active metabolite, in human plasma and urine. J. Pharm. Biomed. Anal., 14, 281 -287 (1996) 
  9. Zhu, Z., Vachareau, A., and Neirinck, L., Liquid chromatographymass spectrometry method for determination of ramipril and its active metabolite ramiprilat in human plasma. J. Chromatogr. B, 779, 297-306 (2002) 
  10. Mabuchi, M., Kano, Y., Fukuyama, T., and Kondo, T., Determination of imidapril and imidaprilat in human plasma by highperformance liquid chromatography-electrospray ionization tandem mass spectrometry. J. Chromatogr. B, 734, 145 -153 (1999) 

이 논문을 인용한 문헌 (0)

  1. 이 논문을 인용한 문헌 없음

원문보기

원문 PDF 다운로드

  • ScienceON :

원문 URL 링크

원문 PDF 파일 및 링크정보가 존재하지 않을 경우 KISTI DDS 시스템에서 제공하는 원문복사서비스를 사용할 수 있습니다. (원문복사서비스 안내 바로 가기)

상세조회 0건 원문조회 0건

이 논문과 연관된 기능

DOI 인용 스타일