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논문 상세정보


In the course of screening anti-dementia agents from natural products, two $\beta$-secretase (BACE1) inhibitors were isolated from the ethyl acetate soluble fraction of Sanguisorbae Radix by the activity-guided purification using silica gel, Sephadex LH-20, and RP-HPLC. They were identified as 1,2,3-trigalloyl-4,6-hexahydroxydiphenoyl-$\beta$-D-glucopyranoside (Tellimagrandin II, 1) and 1,2,3,4,6-pentagalloyl-$\beta$-D-glucopyranoside (2) and were shown to non-competitively inhibit $\beta$-secretase (BACE1) with the $IC_{50}$ values of $3.10{\times}10^{-6}M\;and\;3.76{\times}10^{-6}M$, respectively. The Ki values of 1 and 2 were $6.84{\times}10^{-6}M\;and\;5.13{\times}10^{-6}M$. They were less inhibitory to asecretase (TACE) and other serine proteases such as chymotrypsin, trypsin, and elastase, suggesting that they were relatively specific inhibitors of BACE1.

참고문헌 (12)

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  12. Jeon, S.-Y., Bae, K-.H., Seong, Y.-H., and Song, K.-S., Green tea catechins as a BACE1 ($\beta$-secretase) inhibitor. Bioorg. Med. Chem. Lett., 13, 3905-3908 (2003) 

이 논문을 인용한 문헌 (6)

  1. 2005. "" 韓國藥用作物學會誌 = Korean journal of medicinal crop science, 13(5): 219~226 
  2. 2006. "" Food science and biotechnology, 15(4): 617~624 
  3. 2008. "" Food science and biotechnology, 17(6): 1165~1170 
  4. 2008. "" Archives of pharmacal research : a publication of the Pharmaceutical Society of Korea, 31(2): 183~187 
  5. 2008. "" Food science and biotechnology, 17(3): 489~494 
  6. 2008. "" Mycobiology, 36(3): 195~197 

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