$\require{mediawiki-texvc}$
  • 검색어에 아래의 연산자를 사용하시면 더 정확한 검색결과를 얻을 수 있습니다.
  • 검색연산자
검색연산자 기능 검색시 예
() 우선순위가 가장 높은 연산자 예1) (나노 (기계 | machine))
공백 두 개의 검색어(식)을 모두 포함하고 있는 문서 검색 예1) (나노 기계)
예2) 나노 장영실
| 두 개의 검색어(식) 중 하나 이상 포함하고 있는 문서 검색 예1) (줄기세포 | 면역)
예2) 줄기세포 | 장영실
! NOT 이후에 있는 검색어가 포함된 문서는 제외 예1) (황금 !백금)
예2) !image
* 검색어의 *란에 0개 이상의 임의의 문자가 포함된 문서 검색 예) semi*
"" 따옴표 내의 구문과 완전히 일치하는 문서만 검색 예) "Transform and Quantization"
쳇봇 이모티콘
안녕하세요!
ScienceON 챗봇입니다.
궁금한 것은 저에게 물어봐주세요.

논문 상세정보

Abstract

In the course of screening anti-dementia agents from natural products, two $\beta$-secretase (BACE1) inhibitors were isolated from the ethyl acetate soluble fraction of Sanguisorbae Radix by the activity-guided purification using silica gel, Sephadex LH-20, and RP-HPLC. They were identified as 1,2,3-trigalloyl-4,6-hexahydroxydiphenoyl-$\beta$-D-glucopyranoside (Tellimagrandin II, 1) and 1,2,3,4,6-pentagalloyl-$\beta$-D-glucopyranoside (2) and were shown to non-competitively inhibit $\beta$-secretase (BACE1) with the $IC_{50}$ values of $3.10{\times}10^{-6}M\;and\;3.76{\times}10^{-6}M$, respectively. The Ki values of 1 and 2 were $6.84{\times}10^{-6}M\;and\;5.13{\times}10^{-6}M$. They were less inhibitory to asecretase (TACE) and other serine proteases such as chymotrypsin, trypsin, and elastase, suggesting that they were relatively specific inhibitors of BACE1.

참고문헌 (12)

  1. Anderson, J. P., Barbour, R., Basi, G. S., Caccavello, R., Davis, D., and Doan, M. et al., Purification and cloning of amyloid precursor protein $\beta$-secretase from human brain. Nature, 402, 533-537 (1999) 
  2. Ghosh A. K., Bilcer G., Harwood C., Kawahama R., Shin, D., Hussain, K. A., Hong, L., Loy, J. A., Nguyen, C., Koelsch, G., Ermolieff, J., and Tang, J., Structure-based design: potent inhibition of human brain memapsin 2 ($\beta$-secretase). J. Med. Chem., 44, 2865-2868 (2001) 
  3. Lee, V. M.-Y., Balin, B. J., Otvos, L., and Trojanowski, J. Q., A major subunit of paired helical filaments and derivatized forms of normal tau. Science, 251, 675-678 (1991) 
  4. Vassar, R., $\beta$-Secretase (BACE) as a drug target for alzheimer's disease. Advanced Drug Delivery Reviews, 54, 1589-1602 (2002) 
  5. Kim, S.-I. and Song, K.-S., 1,2,3,4,6-Pentagalloyl-$\beta$-D-glucopyranose, a prolyl endopeptidase inhibitor from Moutan cortex. J. Korean Soc. Agric. Chem. Biotechnol., 43, 158-161 (2000) 
  6. Glenner, G. G. and Wong, C. W., Alzheimer's disease: initial report of the purification and characterization of a novel cerebrovascular amyloid protein. Biochem. Biophys. Res. Commun., 120, 885-890 (1984) 
  7. Ghosh, A. K., Shin, D., Downs, D., Koelsch, G., Lin, X., Ermolieff, J., and Tang, J., Design of potent inhibitors for human brain memapsin 2 ($\beta$-secretase). J. Am. Chem. Soc., 122, 3522- 3523 (2000) 
  8. Terry, R. D., Masliah, E., and Hansen, L. A., The neuropathology of Alzheimer disease and the structural basis of its cognitive alterations, in: R. D. Terry et al. (Ed.), Alzheimer Disease, Lippincott, Williams and Wilkins, Philadelphia, pp. 187-206 (1999) 
  9. Feldman, K. S. and Sahasrabudhe, K., Ellagitannin Chemistry. Syntheses of tellimagrandin and a dehydrodigalloyl ethercontaining dimeric gallotannin analogue of coriariin A. J. Org. Chem., 64, 209-216 (1999) 
  10. Tung J. S., Davis D. L., Anderson J. P., Walker D. E., Mamo S., Jewett N., Hom R. K., Sinha S., Thorsett E. D., and John V., Design of substrate-based inhibitors of human $\beta$-secretase. J. Med. Chem., 45, 259-262, (2002) 
  11. Citron, M., $\beta$-Secretase as a target for the treatment of Alzheimer's disease. J. Neurosci. Res., 70, 373-379 (2002) 
  12. Jeon, S.-Y., Bae, K-.H., Seong, Y.-H., and Song, K.-S., Green tea catechins as a BACE1 ($\beta$-secretase) inhibitor. Bioorg. Med. Chem. Lett., 13, 3905-3908 (2003) 

이 논문을 인용한 문헌 (6)

  1. 2005. "" 韓國藥用作物學會誌 = Korean journal of medicinal crop science, 13(5): 219~226 
  2. 2006. "" Food science and biotechnology, 15(4): 617~624 
  3. 2008. "" Food science and biotechnology, 17(6): 1165~1170 
  4. 2008. "" Archives of pharmacal research : a publication of the Pharmaceutical Society of Korea, 31(2): 183~187 
  5. 2008. "" Food science and biotechnology, 17(3): 489~494 
  6. 2008. "" Mycobiology, 36(3): 195~197 

DOI 인용 스타일