[논문]정상 범위 내 혈청 GGT와 심혈관계질환의 위험요인과의 관련성

임지선; 김유진; 양진훈; 이덕희; 감신; 천병렬

정상 범위 내 혈청 GGT와 심혈관계질환의 위험요인과의 관련성
The Association between Serum GGT Level within Normal Range and Risk Factors of Cardiovascular Diseases 원문보기

Journal of preventive medicine and public health = 예방의학회지, v.38 no.1, 2005년, pp.101 - 106

임지선 (경북대학교 건강증진연구소) , 김유진 (경북대학교 건강증진연구소) , 양진훈 (경북대학교 건강증진연구소) , 이덕희 (경북대학교 건강증진연구소) , 감신 (경북대학교 건강증진연구소) , 천병렬 (경북대학교 건강증진연구소)

Abstract ▼ AI-Helper

Objectives : We conducted this study to examine the association between serum GGT levels within the normal range and the risk factors of cardiovascular diseases Methods : We examined the cross-sectional association between serum GGT and the systolic and diastolic blood pressure, fasting blood glucose, total cholesterol, triglyceride, high density lipoprotein cholesterol (HDLcholesterol), and uric acid among 975 subjects that participated in the health examination of a university hospital located in Daegu city. All the patients' GGT levels were within the normal range. Results : After adjustment were made for age, body mass index (BMI), smoking status, drinking frequency, exercise frequency and coffee intake, the serum GGT level was positively associated with fasting blood glucose (p<0.01), total cholesterol (p<0.01), and triglyceride (p<0.01) in men, and it was positively associated with fasting blood glucose (p<0.01), total cholesterol (p<0.05), triglyceride (p<0.01), and uric acid (p<0.01) in women. The associations were not significantly different depending on the status of alcohol drinking or obesity, except for the associations of serum GGT with diastolic blood pressure (P for interaction=0.04) and uric acid (P for interaction=0.04) between the lean and obese subjects. Conclusions : Serum GGT levels within the normal range were positively associated with fasting blood glucose, triglyceride and uric acid in most subgroups irrespective of the drinking or obesity status. These results suggest that GGT has important clinical implications as being more than just a marker of alcohol consumption and hepatobiliary disease.

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참고문헌 (39)

Wannamethee G, Ebrahim S, Shaper AG. Gamma-glutamyltransferase: determinants and association with mortality from ischemic heart disease and all causes. Am J Epidemiol 1995; 142: 699-708

상세보기
Perry IJ, Wannamethee SG, Shaper AG. Prospective study of serum gammaglutamyltransferase and risk of NIDDM. Diabetes Care 1998; 21: 732-737

상세보기
Miura K, Nakagawa H, Nakamura H, Serum gamma-glutamyl transferase level in predicting hypertension among male drinkers. J Hum Hypertens 1994; 8: 445-449

상세보기
Jousilahti P, Rastenyte D, Tuomilehto J. Serum gamma-glutamyl transferase, self-reported alcohol drinking, and the risk of stroke. Stroke 2000; 31: 1851-1855

상세보기
Lee DH, Ha MH, Kim JR, Gross M, Jacobs DR. Gamma-glutamyltransferase, alcohol, and blood pressure: a four year follow-up study. Ann Epidemiol 2002; 12: 90-96

상세보기
Lee DH, Ha MH, Kim JH, et al. Gammaglutamyltransferase and diabetes-A 4 year follow-up study. Diabetologia 2003; 4: 359-364
Lee DH, Jacobs DR, Gross M. Gamma glutamyltransferase is a predictor of incident diabetes and hypertension: Cardia Study. Clini Chem 2003; 49: 1358-1366

상세보기
Kim KY, Kam S, Lee JH, Ha YA, Lee KE. A cross-sectional study on $\gamma$ -GTP and its related factors in male workers. Korean J Prev Med 2002; 35(2): 167-174 (Korean)
Gray DS. Diagnosis and prevalence of obesity. Med Clin North Am 1989; 73(1): 1-13

상세보기
Skurtveit S, Tverdal A. Sex differences in gamma-glutamyltransferase in people aged 40-42 years in two Norwegian counties. Drug Alcohol Depend 2002; 67: 95-98

상세보기
Nilssen O, Forde OH, Brenn T. The Tromso Study. Distribution and population determinants of gamma-glutamyltransferase. Am J Epidemiol 1990; 132: 318-326

상세보기
Pintus, F, Mascia P. Distribution and population determinants of gamma-glutamyltransferase in a random sample of Sardinian inhabitants. Eur J Epidemiol 1996; 12: 71-76

상세보기
Lee DH, Gross M, Jacobs DR. The association of serum carotenoids and tocopherol with gamma glutamyltransferase: the CARDIA study. Clin Chem 2004; 50: 582-588

상세보기
Lee DH, Steffen LM, Jacobs DR. Association between serum gamma-glutamyltransferase and dietary factors: CARDIA study. Am J Clin Nutr 2004; 79: 600-605

상세보기
Lim JS, Yang JH, Chun BY, Kam S, Jacobs DR, Lee DH. Is serum ${\gamma}$ -glutamyltransferase inversely associated with serum antioxidants as a marker of oxidative stress? Free Radic Biol Med 2004; 37: 1018-1023

상세보기
Whitfield JB. Gamma glutamyl transferase. Crit Rev Clin Lab Sci 2001; 38: 263-355

상세보기
Kugelman A, Choy HA, Liu R. gamma- Glutamyl transpeptidase is increased by oxidative stress in rat alveolar L2 epithelial cells. Am J Respir Cell Mol Biol 1994; 11: 586-592

상세보기
Takahashi Y, Oakes SM, Williams MC. Nitrogen dioxide exposure activates gammaglutamyl transferase gene expression in rat lung. Toxoicol Appl Pharmacol 1997; 143: 388-396

상세보기
Hybertson BM, Lee YM, Cho HG. Alveolar type II cell abnormalities and peroxide formation in lungs of rats given IL-1 intratracheally. Inflammation 2000; 24: 289-303

상세보기
Hull J, Vervaart P, Grimwood K. Pulmonary oxidative stress response in young children with cystic fibrosis. Thorax 1997; 52: 557-560

상세보기
Shi M, Gozal E, Choy HA. Extracellular glutathione and gamma-glutamyl transpeptidase prevent H2O2-induced injury by 2,3- dimethoxy-1,4-naphthoquinone. Free Radic Biol Med 1993; 15: 57-67

상세보기
Markey CM, Rudolph DB, Labus JC. Oxidative stress differentially regulates the expression of gamma-glutamyl transpeptidase mRNAs in the intial segment of the rat epididymis. J Androl 1998; 19: 92-99

상세보기
Karp DR, Shimooku K, Lipsky PE. Expression of gamma-Glutamyl Transpeptidase protects Ramos B cells from oxidation-induced cell death. J Biol Chem 2001; 276: 3798-3804

상세보기
Stark AA. Oxidative metabolism of glutathione by gamma-glutamyl transpeptidase and peroxisome proliferation: the relevance to hepatocarcinogenesis. A hypothesis. Mutagenesis 1991; 6: 241-245

상세보기
Stark AA, Rusell JJ, Langenbach R. Localization of oxidative damage by a glutathionegamma-glutamyl transpeptidase system in preneoplastic lesions in sections of livers from carcinogen-treated rats. Carcinogenesis 1994; 15: 343-348

상세보기
Zalit I, Glass GA, Stark AA. The role of chelators in the catalysis of glutathionegamma- glutamyl transpeptidase dependent lipid peroxidation by transition metals. Biochem Mol Biol Int 1996; 40: 1123-1133

상세보기
Stark AA, Glass GA. Role of copper and ceruloplasmin in oxidative mutagenesis induced by the glutathione-gamma-glutamyl transpeptidase system and by other thiols. Environ Mol Mutagen 1997; 29: 63-72

상세보기
Glass GA, Stark AA. Promotion of glutathione- gamma-glutamyl transpeptidasedependent lipid peroxidation by copper and ceruloplasmin: the requirement for iron and the effects of antioxidants and antioxidant enzymes. Environ Mol Mutagen 1997; 29: 73-80
Paolicchi A, Tongiani R, Tonarelli P, et al. gamma-Glutamyl transpeptidase-dependent lipid peroxidation in isolated hepatocytes and HepG2 hepatoma cells. Free Radic Biol Med 1997; 22: 853-360

상세보기
Drozdz R, Parmentier C, Hachad H. gamma- Glutamyltransferase dependent generation of reactive oxygen species from a glutathione/ transferrin system. Free Radic Biol Med 1998; 25: 786-792

상세보기
Bandyopadhyay D, Chattopadhyay A, Ghosh G, Datta AG. Oxidative stress-induced ischemic heart disease: protection by antioxidants. Curr Med Chem 2004; 11: 369-387

상세보기
Dhalla NS, Golfman L, Takeda S, Takeda N, Nagano M. Evidence for the role of oxidative stress in acute ischemic heart disease: a brief review. Can J Cardiol 1999; 15: 587-593

상세보기
Janero DR. Ischemic heart disease and antioxidants: mechanistic aspects of oxidative injury and its prevention. Crit Rev Food Sci Nutr 1995; 35: 65-81

상세보기
Wojcicka G, Beltowski J, Jamroz A. Oxidative stress in hypertension. Postepy Hig Med Dosw 2004; 58: 183-193
Bonnefont-Rousselot D, Beaudeux JL, Therond P, Peynet J, Legrand A, Delattre J. Diabetes mellitus, oxidative stress and advanced glycation endproducts. Ann Pharm Fr 2004; 62: 147-157

상세보기
Aikawa M, Sugiyama S, Hill CC, Voglic SJ, Rabkin E, Fukumoto Y, Schoen FJ, Witztum JL, Libby P. Lipid lowering reduces oxidative stress and endothelial cell activation in rabbit atheroma. Circulation 2002; 106: 1390-1396

상세보기
Machin M, Simoyi MF, Blemings KP, Klandorf H. Increased dietary protein elevates plasma uric acid and is associated with decreased oxidative stress in rapidly-growing broilers. Comp Biochem Physiol B Biochem Mol Biol 2004; 137: 383-390

상세보기
Waring WS, Convery A, Mishra V, Shenkin A, Webb DJ, Maxwell SR. Uric acid reduces exercise-induced oxidative stress in healthy adults. Clin Sci (Lond) 2003; 105: 425-430

상세보기
Staub M. Uric acid as a scavenger in oxidative stress. Orv Hetil 1999; 140: 275-279

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정상 범위 내 혈청 GGT와 심혈관계질환의 위험요인과의 관련성
The Association between Serum GGT Level within Normal Range and Risk Factors of Cardiovascular Diseases 원문보기

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정상 범위 내 혈청 GGT와 심혈관계질환의 위험요인과의 관련성 The Association between Serum GGT Level within Normal Range and Risk Factors of Cardiovascular Diseases 원문보기

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정상 범위 내 혈청 GGT와 심혈관계질환의 위험요인과의 관련성
The Association between Serum GGT Level within Normal Range and Risk Factors of Cardiovascular Diseases 원문보기