뇌전이 종양의 발견에 있어서 Doble dose Gd-DTPA를 이용한 3 T MRI와 1.5 T MRI간의 비교연구 Evaluation between 3.0 T vs 1.5 T MRI in Detection of Brain Metastasis using Double Dose Gd-DTPA원문보기
목적: 작은 뇌전이 종양의 조기 발견은 중요하다. 이 연구의 목적은 1.5 T MRI와 3.0 T MRI 간의 크기에 따른 뇌전이 종양의 발견율을 비교하는 것이다. 대상 및 방법: 폐암으로 진단 받은 162명의 환자를 대상으로 TNM 병기를 위해 뇌 MRI를 시행하였다. Gd-DTPA 를 2배 용량으로 투여 후, 3.0 T MRI에서 훼손경사회복획득으로 촬영하였으며 그 후 1.5 T MRI에서 T1 스핀 에코로 촬영하였다. 3명의 방사선과 전문의가 합의하여 MRI를 판독하였으며 정성 평가를 시행하였다. 3.0 T와 1.5 T MRI에서 크기에 따라 민감도, 양성 예측률, 정확도를 평가하였다. 신호 강도를 사용하여 전이 종양과 인접 조직간의 신호강도 비를 계산하였다. 결과: 162명의 환자 중 31명에서 1.5 T 또는 3.0 T MR에 뇌전이 종양이 발견되었다. 3.0 T MRI에서 143개의 종양이 발견되었으나 1.5 T MRI에서 137개의 종양이 발견되었다. 6개의 종양이 3.0 T MRI에서만 발견되었으며 크기는 모두 3 mm 미만이었다. 3.0 T MRI의 민감도, 양성 예측률, 정확도는 각각 100%, 100%, 100%이며, 1.5 T MRI에서는 각각 95.8%, 88.3%, 85.1% 이다. SI ratio는 1.5 T MRI보다 3.0 T MRI에서 유의하게 높았다(p=0.025). 결론: Double dose Gd-DTPA를 이용한 3.0 T MRI는 3 mm미만의 뇌전이 종양을 발견하는데 있어서 1.5 T MRI 보다 우수하다.
목적: 작은 뇌전이 종양의 조기 발견은 중요하다. 이 연구의 목적은 1.5 T MRI와 3.0 T MRI 간의 크기에 따른 뇌전이 종양의 발견율을 비교하는 것이다. 대상 및 방법: 폐암으로 진단 받은 162명의 환자를 대상으로 TNM 병기를 위해 뇌 MRI를 시행하였다. Gd-DTPA 를 2배 용량으로 투여 후, 3.0 T MRI에서 훼손경사회복획득으로 촬영하였으며 그 후 1.5 T MRI에서 T1 스핀 에코로 촬영하였다. 3명의 방사선과 전문의가 합의하여 MRI를 판독하였으며 정성 평가를 시행하였다. 3.0 T와 1.5 T MRI에서 크기에 따라 민감도, 양성 예측률, 정확도를 평가하였다. 신호 강도를 사용하여 전이 종양과 인접 조직간의 신호강도 비를 계산하였다. 결과: 162명의 환자 중 31명에서 1.5 T 또는 3.0 T MR에 뇌전이 종양이 발견되었다. 3.0 T MRI에서 143개의 종양이 발견되었으나 1.5 T MRI에서 137개의 종양이 발견되었다. 6개의 종양이 3.0 T MRI에서만 발견되었으며 크기는 모두 3 mm 미만이었다. 3.0 T MRI의 민감도, 양성 예측률, 정확도는 각각 100%, 100%, 100%이며, 1.5 T MRI에서는 각각 95.8%, 88.3%, 85.1% 이다. SI ratio는 1.5 T MRI보다 3.0 T MRI에서 유의하게 높았다(p=0.025). 결론: Double dose Gd-DTPA를 이용한 3.0 T MRI는 3 mm미만의 뇌전이 종양을 발견하는데 있어서 1.5 T MRI 보다 우수하다.
Purpose : Early detection of small brain metastases is important. The purpose of this study was to compare the detectability of brain metastases according to the size between 1.5 T and 3.0 T MRI. Materials and Methods : We reviewed 162 patients with primary lung cancer who were examined for TNM stag...
Purpose : Early detection of small brain metastases is important. The purpose of this study was to compare the detectability of brain metastases according to the size between 1.5 T and 3.0 T MRI. Materials and Methods : We reviewed 162 patients with primary lung cancer who were examined for TNM staging. After administration of double dose of Gd-DTPA, MR imaging was performed with SPGR by 3.0 T MRI and then with T1 SE sequence by 1.5 T MRI. In each patient, three readers performed qualitative assessment. Sensitivity, positive predictive value, and diagnostic accuracy were calculated in 3.0 T and 1.5 T MRI according to size. Using the signal intensity (SI) measurements between the metastatic nodules and adjacent tissue, nodule-to-adjacent tissue SI ratio was calculated. Results : Thirty-one of 162 patients had apparent metastatic nodules in the brain at either 1.5 T or 3.0 T MR imaging. 143 nodules were detected in 3.0 T MRI, whereas 137 nodules were detected at 1.5 T MRI. Six nodules, only detected in 3.0 T MRI, were smaller than 3.0 mm in dimension. Sensitivity, positive predictive value, and diagnostic accuracy in 3.0 T MRI were 100 %, 100 %, and 100 % respectively, and in 1.5 T MRI were 95.8%, 88.3%, and 85.1% respectively. SI ratio was significantly higher in the 3.0 T MRI than 1.5 T MRI (p=0.025). Conclusion : True positive rate of 3.0 T MRI with Gd-DTPA was superior to 1.5 T MRI with Gd-DTPA in detection of metastatic nodules smaller than 3.0 mm.
Purpose : Early detection of small brain metastases is important. The purpose of this study was to compare the detectability of brain metastases according to the size between 1.5 T and 3.0 T MRI. Materials and Methods : We reviewed 162 patients with primary lung cancer who were examined for TNM staging. After administration of double dose of Gd-DTPA, MR imaging was performed with SPGR by 3.0 T MRI and then with T1 SE sequence by 1.5 T MRI. In each patient, three readers performed qualitative assessment. Sensitivity, positive predictive value, and diagnostic accuracy were calculated in 3.0 T and 1.5 T MRI according to size. Using the signal intensity (SI) measurements between the metastatic nodules and adjacent tissue, nodule-to-adjacent tissue SI ratio was calculated. Results : Thirty-one of 162 patients had apparent metastatic nodules in the brain at either 1.5 T or 3.0 T MR imaging. 143 nodules were detected in 3.0 T MRI, whereas 137 nodules were detected at 1.5 T MRI. Six nodules, only detected in 3.0 T MRI, were smaller than 3.0 mm in dimension. Sensitivity, positive predictive value, and diagnostic accuracy in 3.0 T MRI were 100 %, 100 %, and 100 % respectively, and in 1.5 T MRI were 95.8%, 88.3%, and 85.1% respectively. SI ratio was significantly higher in the 3.0 T MRI than 1.5 T MRI (p=0.025). Conclusion : True positive rate of 3.0 T MRI with Gd-DTPA was superior to 1.5 T MRI with Gd-DTPA in detection of metastatic nodules smaller than 3.0 mm.
* AI 자동 식별 결과로 적합하지 않은 문장이 있을 수 있으니, 이용에 유의하시기 바랍니다.
제안 방법
2 mmol/kg). First, examinations were performed on a 3.0 T MR scanner and then were subsequently performed on a 1.5 T MR scanner without additional contrast injection. The scan interval between the 3.
In addition, the sensitivity, specificity, positive predictive value, negative predictive value, and diagnostic accuracy of the 3.0 T and 1.5 T MRI were calculated using the results from the final interpretation according to size.
MR imaging included the following sequences on both scanners: At 3.0 T MRI, an axial 3D SPGR, which is usually used at present, was used (TR/TE/TI 5.7/1.44/400 milliseconds; flip angle 20°; 2 mm slice thickness; FOV of 220 mm; matrix size of 512X512 ZIP; spatial resolution of 0.43X0.43X2 mm; two acquisition) with a scan time of 3 minutes 30 seconds. At 1.
The paired Wilcoxon’s signed ranks test was used to compare qualitative scores, and the matched-pair-t test was used to compare nodule SI ratios between the 3.0 T and 1.5 T MRI with a double dose of Gd-DTPA. For all tests, significance was set at p < 0.
The presence, size, and number of metastatic nodules were assessed. The postcontrast images were divided into the following two groups: 3.0 T MRI with a double dose of Gd-DTPA and 1.5 T MRI with a double dose of Gd-DTPA. The readers were asked to document the number of nodules.
5 T MRI with an axial T1-weighted spin echo sequence (SE), the higher field strength MR systems combined with a sequence of SPGR (spoiled gradient recalled acquisition in the steady state) and administration of a high dose of Gd-DTPA (gadopentetate dimeglumine) may also have advantages in detecting small metastases, although this has not yet been verified by clinical data. The purpose of this study is to compare the detectability of brain metastases classified according to the size of nodules, between thin slice SPGR of 3.0 T and conventional thick slice SE of 1.5 T MRI with the administration of a double dose of Gd- DTPA.
0 T images.17 The purpose of this study was to detect early small brain metastases, so using the SPGR sequence with a 3.0 T MRI, which is usually used at present, has advantages for detecting early small brain metastases. The second limitation was that the scan interval between the 1.
대상 데이터
4. A 64-year-old male with multiple brain metastases. (ol The3.
3. A 65-year-old male with multiple brain metastases. (a) The3.
1. A 65-year-old male with single brain metastasis. (a) The 3.
5. A 67-year-old female with multiple brain metastases. (a) The3.
2. A 73-year-old male with multiple brain metastases. Metastatic nodule (a) by a 3.
성능/효과
Forty- five of 137 nodules were satisfactory in both conditions. By consensus, the final review stated, nodules detected by the 3.0 T and 1.5 T MRI were consideredpositive for metastases (Table 2). Additionally, there were 18 pseudolesions which were detected as nodules by the 1.
5 T MRI with a double dose of Gd- DTPA due to partial volume artifact. Eighteen lesions were detected in the 1.5 T MRI with a double dose of Gd-DTPA, which proved to be vascular structures in3.0 T MRI with a double dose of Gd- DTPA. The true nature of these lesions was revealed because of the greater morphologic detail visualized by the high fieldstrength MR image, thus allowing differentiation between true enhancing lesions and sulcal vessels.
0 T MRI with a double dose of Gd-DTPA were 100%, 100%, and 100% respectively. For metastatic nodules smaller than 3 mm, the sensitivity, positive predictive value, and diagnostic accuracy of the 1.5 T MRI with a double dose of Gd-DTPA were 87.8%, 70.5%, and 64.2% respectively. The sensitivity, positive predictive value, and diagnostic accuracy of 3.
For quantitative image assessment, the SI ratio in the post contrast sequences (Table 4) was significantly higher in the 3.0 T MRI with a double dose of Gd- DTPA than in the 1.5 T MRI with a double dose of Gd-DTPA (p = 0.025).
In 6 of the 31 cases, six nodules, which were only detected by the 3.0 T MRI with a double dose of Gd- DTPA, and missed by the 1.5 T MRI with a double dose of Gd-DTPA, were unanimously agreed upon by all participants in the final interpretation. In three of the six nodules, a growing nodule was detected during a follow-up MR scan which confirmed the presence of metastases (Fig.
In the final review made by consensus of three radiologists (Table 1), a total of 143 metastatic nodules were detected by the 3.0 T MRI with a double dose of Gd-DTPA. Of these nodules, 49 nodules were < 3 mm in diameter, 37 nodules were 3 mm to 5 mm, and 57 nodules were >5 mm.
2% respectively. The sensitivity, positive predictive value, and diagnostic accuracy of 3.0 T MRI with a double dose of Gd-DTPA were 100%, 100%, and 100% respectively (Table 3).
1% respectively. The sensitivity, positive predictive value, and diagnostic accuracy of the 3.0 T MRI with a double dose of Gd-DTPA were 100%, 100%, and 100% respectively. For metastatic nodules smaller than 3 mm, the sensitivity, positive predictive value, and diagnostic accuracy of the 1.
5). The sensitivity, positive predictive values, and diagnostic accuracy of the 1.5 T MRI with a double dose of Gd-DTPA were 95.8%, 88.3%, and85.1% respectively. The sensitivity, positive predictive value, and diagnostic accuracy of the 3.
Of these nodules, 43 nodules were < 3 mm in diameter. The3.0 T MRI with a double dose of Gd-DTPA was significantly more effective at detecting nodules smaller than 3 mm (p = 0.014) than the 1.5 T MRI. However, we found no significant difference in the detection of nodules larger than 3 mm (p > 0.
※ AI-Helper는 부적절한 답변을 할 수 있습니다.