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논문 상세정보

Abstract

Bioassay-guided fractionation of methanol extract of Reynoutria sachalinensis flower using DPPH assay has led to the isolation of three anthraquinones and three flavonoids. Their structures were identified as emodin (1), emodin-8-O-$\beta$-D-glucopyranoside (2), physcion-8-O-$\beta$-D­glucopyranoside (3), quercetin-3-O-$\alpha$-L-arabinofuranoside (4), quercetin-3-O-$\beta$-D-galactopyra­noside (5), and quercetin-3-O-$\beta$-D-glucuronopyranoside (6) by comparing their physicochemical and spectral data with those published in literatures. All isolated compounds were evaluated for antioxidant activities with free radical 1, 1-diphenyl-2-picrylhydrazyl (DPPH) scavenging, superoxide radical scavenging and $Cu^{2+}$-mediated low density lipoprotein (LDL) oxidation assay. The results demonstrated that three flavonoids, 4, 5, and 6 had remarkable antioxidant activities with the $IC_{50}$ values of 64.3, 54.7, and 46.2${\mu}M$ (DPPH scavenging), the $IC_{50}$ values of 6.0, 6.7, and $4.4{\mu}M$ (superoxide radical scavenging) and the $IC_{50}$ values of 3.8, 3.2, and 5.4${\mu}M$ against LDL oxidation, respectively.

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이 논문을 인용한 문헌 (8)

  1. An, Ren-Bo ; Kwon, Ji-Wung ; Kwon, Tae-Oh ; Chung, Wan-Tae ; Lee, Hye-Suk ; Kim, Youn-Chul 2007. "Chemical constituents from the whole plants of Euphorbia supina Rafin" 생약학회지, 38(3): 291~295 
  2. 2008. "" Journal of applied biological chemistry, 51(1): 13~16 
  3. 2008. "" Archives of pharmacal research : a publication of the Pharmaceutical Society of Korea, 31(5): 598~605 
  4. Lee, Yun-Mi ; Kim, Young-Sook ; Kim, Jong-Min ; Jang, Dae-Sik ; Kim, Joo-Hwan ; Yoo, Jeong-Lim ; Kim, Jin-Sook 2008. "Screening of Korean Herbal Medicines with Inhibitory Activity on Advanced Glycation End Products (AGEs) Formation (II)" 생약학회지, 39(3): 223~227 
  5. Hong, Hyun-Kyung ; Kwak, Jong-Hwan ; Kang, Se-Chan ; Lee, Jong-Wook ; Park, Jong-Hyuk ; Ahn, Jong-Woong ; Kang, Hye-Sook ; Choung, Eui-Su ; Zee, Ok-Pyo 2008. "Antioxidative Constituents from the Whole Plants of Euphorbia supina" 생약학회지, 39(3): 260~264 
  6. 2009. "" Archives of pharmacal research : a publication of the Pharmaceutical Society of Korea, 32(10): 1373~1377 
  7. 2011. "" Natural product sciences, 17(2): 65~79 
  8. 2011. "" Journal of the Korean Society for Applied Biological Chemistry, 54(2): 308~311 

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