$\require{mediawiki-texvc}$
  • 검색어에 아래의 연산자를 사용하시면 더 정확한 검색결과를 얻을 수 있습니다.
  • 검색연산자
검색연산자 기능 검색시 예
() 우선순위가 가장 높은 연산자 예1) (나노 (기계 | machine))
공백 두 개의 검색어(식)을 모두 포함하고 있는 문서 검색 예1) (나노 기계)
예2) 나노 장영실
| 두 개의 검색어(식) 중 하나 이상 포함하고 있는 문서 검색 예1) (줄기세포 | 면역)
예2) 줄기세포 | 장영실
! NOT 이후에 있는 검색어가 포함된 문서는 제외 예1) (황금 !백금)
예2) !image
* 검색어의 *란에 0개 이상의 임의의 문자가 포함된 문서 검색 예) semi*
"" 따옴표 내의 구문과 완전히 일치하는 문서만 검색 예) "Transform and Quantization"
쳇봇 이모티콘
안녕하세요!
ScienceON 챗봇입니다.
궁금한 것은 저에게 물어봐주세요.

논문 상세정보

Abstract

Leukocyte adhesion to the vascular endothelium is a critical initiating step in inflammation and atherosclerosis. We have herein studied the effect of manassantin A (1) and S (2), dineolignans, on interaction of THP-1 monocytic cells and human umbilical vein endothelial cells (HUVEC) and expression of intercellular adhesion molecule-1 (ICAM-1), vascular cell adhesion molecule-1 (VCAM-1), and E-selectin in HUVEC. When HUVEC were pretreated with 1 and 2 followed by stimulation with $TNF-{\alpha}$, adhesion of THP-1 cells to HUVEC decreased in dose-dependent manner with $IC_{50}$ values of 5 ng/mL and 7 ng/mL, respectively, without cytotoxicity. Also, 1 and 2 inhibited $TNF-{\alpha}-induceda$ up-regulation of ICAM-1, VCAM-1 and E-selectin. The present findings suggest that 1 and 2 prevent monocyte adhesion to HUVEC through the inhibition of ICAM-1, VCAM-1 and E-selectin expression stimulated by $TNF-\alpha$, and may imply their usefulness for the prevention of atherosclerosis relevant to endothelial activation.

참고문헌 (25)

  1. Berk, B. C., Abe, J. I., Min, W., Surapisitchat, J., and Yan, C., Endothelial atheroprotective and anti-inflammatory mechanisms. Ann. N. Y. Acad. Sci., 947, 93-111 (2001) 
  2. Bevilacqua, M. P., Endothelial-leukocyte adhesion molecules. Annu. Rev. Immunol., 11, 767-804 (1993) 
  3. Bevilacqua, M. P., Nelson, R. M., Mannori, G., and Cecconi, O., Endothelial-leuckocyte adhesion molecules in human disease. Annu. Rev. Med., 45, 361-378 (1994) 
  4. Chen, Y. -H., Lin, S. -J., Ku, H. -H., Shiao, M. -S., Lin, F. -Y., Chen, J. -W., and Chen, Y. -L., Salvianolic acid B attenuates VCAM-1 and ICAM-1 expression in TNF-${\alpha}$-treated human aortic endothelial cells. J. Cell Biochem., 82, 512-521 (2001) 
  5. Cybulsky, M. I., and Gimbrone, M. A. Jr., Endothelial expression of a mononuclear leukocyte adhesion molecule during atherogenesis. Science, 251, 788-791 (1991) 
  6. Hwang, B. Y., Lee, J. -H., Nam, J. B., Hong, Y. -S., and Lee, J. J., Lignans from Saururus chinensis inhibiting the transcription factor NF-${\kappa}$B. Phytochemistry, 64, 765-771 (2003) 
  7. Imhof, B. A. and Dunon, D., Leukocyte migration and adhesion. Adv. Immunol., 58, 345-416 (1995) 
  8. Kraft, C., Jenett-Siems, K., Kohler, I., Tofern-Reblin, B., Siems, K., Bienzle, U., and Eich, E., Antiplasmodial activity of sesquilignans and sesquineolignans from Bonamia spectabilis. Phytochemistry, 60, 167-173 (2002) 
  9. Lee, J. -H., Hwang, B. Y., Kim, K. -S., Nam, J. B., Hong, Y. S., and Lee, J. J., Suppression of RelA/p65 transactivation activity by a lignoid manassantin isolated from Saururus chinensis. Biochem. Pharmacol., 66, 1925-1933 (2003) 
  10. Lee, W. S., Lee, D. -W., Baek, Y. -I., An, S. -J., Cho, K.- H., Choi, Y. -K., Kim, H. -C., Park, H. -Y., Bae, K. -H., and Jeong, T. -S., Human ACAT-1 and -2 inhibitory activities of saucerneol B, manassantin A and B isolated from Saururus chinensis. Bioorg. Med. Chem. Lett., 14, 3109-3112 (2004) 
  11. Modur, V., Zimmerman, G. A., Prescott, S. M., and McIntyre, T. M., Endothelial cell inflammatory responses to tumor necrosis factor-${\alpha}$. Ceramide-dependent and -independent mitogen-activated protein kinase cascades. J. Biol. Chem., 271, 13094-13102 (1996) 
  12. Mosmann, T., Rapid colorimetric assay for cellular growth and survival: Application to proliferation and cytotoxicity assays. J. Immunol. Methods, 65, 55-63 (1983) 
  13. Pfeffer, K., Matsuyama, T., Kundig, T. M., Wakeham, A., Kishihara, K., Shahinian, A., Wiegmann, K., Ohashi, P. S., Kronke, M., and Mak, T. W., Mice deficient for the 55 kd tumor necrosis factor receptor are resistant to endotoxic shock, yet succumb to L. monocytogenes infection. Cell, 73, 457-467 (1993) 
  14. Pober, J. S. and Cotran, R. S., Cytokines and endothelial cell biology. Physiol. Rev., 70, 427-451 (1990) 
  15. Rao, K. V. and Alvarez, F. M., Manassantins A/B and saucerneol: Novel biologically active lignoids from Saururus cernuus. Tetrahedron Lett., 24, 4947-4950 (1983) 
  16. Rao, K. V., Puri, V. N., Diwan, P. K., and Alvarez, F. M., Preliminary evaluation of manassantin A, a potential neuroleptic agent from Saururus cernuus. Pharmacol. Res. Commun., 19, 629- 638 (1987) 
  17. Rho, M. C., Kwon, O. E., Kim, K., Lee, S. W., Chung, M. Y., Kim, Y. H., Hayashi, M., Lee, H. S., and Kim, Y. K., Inhibitory effects of manassantin A and B isolated from the roots of Saururus chinensis on PMA-induced ICAM-1 expression. Planta Med., 69, 1147-1149 (2003) 
  18. Ross, R., Atherosclerosis - An inflammatory disease. N. Engl. J. Med., 340, 115-126 (1999) 
  19. Springer, T. A., Traffic signals for lymphocyte recirculation and leukocyte emigration: The multistep paradigm. Cell, 76, 301- 314 (1994) 
  20. Stannard, A. K., Riddell, D. R., Bradley, N. J., Hassall, D. G., Graham, A., and Owen, J. S., Apolipoprotein E and regulation of cytokine-induced cell adhesion molecule expression in endothelial cells. Atherosclerosis, 139, 57-64 (1998) 
  21. Surapisitchat, J., Hoefen, R. J., Pi, X., Yoshizumi, M., Yan, C., and Berk, B. C., Fluid shear stress inhibits TNF-${\alpha}$ activation of JNK but not ERK1/2 or p38 in human umbilical vein endothelial cells: inhibitory crosstalk among MAPK family members. Proc. Natl. Acad. Sci. U.S.A., 98, 6476-6481 (2001) 
  22. Tsuchiya, S., Yamabe, M., Yamaguchi, Y., Kobayashi, Y., Konno, T., and Tada, K., Establishment and characterization of a human acute leukemia cell line (THP-1). Int. J. Cancer, 26, 171-176 (1980) 
  23. Van der Wal, A. C., Das, P. K., Tigges, A. J., and Becker, A. E., Adhesion molecules on the endothelium and mononuclear cells in human atherosclerotic lesions. Am. J. Pathol., 141, 1427-1433 (1992) 
  24. Vaporciyan, A. A., Jones, M. L., and Ward, P. A., Rapid analysis of leukocyte-endothelial adhesion. J. Immunol. Methods, 159, 93-100 (1993) 
  25. Zhang, W. J. and Feri, B., ${\alpha}$-Lipoic acid inhibits TNF-${\alpha}$-induced NF-${\kappa}$B activation and adhesion molecule expression in human aortic endothelial cells. FASEB J., 15, 2423-2432 (2001) 

이 논문을 인용한 문헌 (0)

  1. 이 논문을 인용한 문헌 없음

원문보기

원문 PDF 다운로드

  • ScienceON :

원문 URL 링크

원문 PDF 파일 및 링크정보가 존재하지 않을 경우 KISTI DDS 시스템에서 제공하는 원문복사서비스를 사용할 수 있습니다. (원문복사서비스 안내 바로 가기)

상세조회 0건 원문조회 0건

DOI 인용 스타일