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Manassantin A and B Isolated from Saururus chinensis Inhibit $TNF-{\\alpha}-Induced$ Cell Adhesion Molecule Expression of Human Umbilical Vein Endothelial Cells 원문보기

Archives of pharmacal research : a publication of the Pharmaceutical Society of Korea, v.28 no.1, 2005년, pp.55 - 60  

Kwon Oh Eok (Laboratory of Lipid Metabolism, Korea Research Institute of Bioscience and Biotechnology) ,  Lee Hyun Sun (Laboratory of Lipid Metabolism, Korea Research Institute of Bioscience and Biotechnology) ,  Lee Seung Woong (Laboratory of Lipid Metabolism, Korea Research Institute of Bioscience and Biotechnology) ,  Chung Mi Yeon (Laboratory of Lipid Metabolism, Korea Research Institute of Bioscience and Biotechnology) ,  Bae Ki Hwan (College of Pharmacy, Chungnam National University) ,  Rho Mun-Chual (Laboratory of Lipid Metabolism, Korea Research Institute of Bioscience and Biotechnology) ,  Kim Young-kook (Laboratory of Lipid Metabolism, Korea Research Institute of Bioscience and Biotechnology)

Abstract ▼ AI-Helper 아이콘AI-Helper

Leukocyte adhesion to the vascular endothelium is a critical initiating step in inflammation and atherosclerosis. We have herein studied the effect of manassantin A (1) and S (2), dineolignans, on interaction of THP-1 monocytic cells and human umbilical vein endothelial cells (HUVEC) and expression ...

주제어

#Manassantin A/B   #Cell adhesion molecules   #Monocyte   #Human umbilical vein endothelial cells   #Atherosclerosis  

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가설 설정

  • Values were presented to % gated (M1; marker of basal level of expression, M2; marker of TNF-a-in血ced expression). (B) The inhibitory effect of 1 on each CAM expression was down-regulated in a dose dependent manner. The % inhibition of ICAM너 expression was presented by more or less of intensity on the M2 values and calculated as follows: [1 - M2 value for TNF-a plus compound treated cells M2 value for unstimulated cells - M2 value for TNF-a treated c이s M2 value for unstimulated cells)] x 100 %.
  • , 2003). In this study, therefore, we investigated that whether 1 and 2 affect to the interaction of monocyte and human umbilical vein endothelial cells (HUVEC) and TNF-a-induced expression of ICAM너, VCAM너, and E- s이ectin in HUVEC.
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