$\require{mediawiki-texvc}$
  • 검색어에 아래의 연산자를 사용하시면 더 정확한 검색결과를 얻을 수 있습니다.
  • 검색연산자
검색연산자 기능 검색시 예
() 우선순위가 가장 높은 연산자 예1) (나노 (기계 | machine))
공백 두 개의 검색어(식)을 모두 포함하고 있는 문서 검색 예1) (나노 기계)
예2) 나노 장영실
| 두 개의 검색어(식) 중 하나 이상 포함하고 있는 문서 검색 예1) (줄기세포 | 면역)
예2) 줄기세포 | 장영실
! NOT 이후에 있는 검색어가 포함된 문서는 제외 예1) (황금 !백금)
예2) !image
* 검색어의 *란에 0개 이상의 임의의 문자가 포함된 문서 검색 예) semi*
"" 따옴표 내의 구문과 완전히 일치하는 문서만 검색 예) "Transform and Quantization"

과학기술 지식인프라 ScienceON

상세검색 다국어 입력
도움말도움말
쳇봇 이모티콘
안녕하세요!
ScienceON 챗봇입니다.
궁금한 것은 저에게 물어봐주세요.

논문 상세정보

MyON담기
내보내기

Bone Loss Preventing Effect of Sophorae Fructus On Ovariectomized Rats

Archives of pharmacal research : a publication of the Pharmaceutical Society of Korea v.28 no.1 , 2005년, pp.106 - 110  
Shim Jae Geul (College of Pharmacy, Chung-Ang University ) ;  Yeom Seung Hwan ( College of Pharmacy, Chung-Ang University ) ;  Kim Hyun Jung ( College of Pharmacy, Chung-Ang University ) ;  Choi Young Wook ( College of Pharmacy, Chung-Ang University ) ;  Lee Do Ik ( College of Pharmacy, Chung-Ang University ) ;  Song Kye Yong ( College of Medicine, Chung-Ang University ) ;  Kwon Suk Hyung ( Rexgene Biotech Co., Ltd. ) ;  Lee Min Won ( College of Pharmacy, Chung-Ang University)
Abstract

The preventive effects of Sophorae Fructus extracts (I: hot water extract and II: combination product using I) on bone loss in ovariectomized (OVX) rats were investigated. Sophorae Fructus extracts were orally administrated to OVX rats for 9 weeks. Ovariectomy caused the increase of body weight and deoxypyridinoline (Dpd: bone resorption marker) and decrease of calcium (Ca: bone formation marker) level in serum. Dpd level were significantly decreased and Ca levels were elevated at 9 weeks in Sophorae Fructus extracts administered groups after ovariectomy at a dose of 0.556 g/kg/day compared with control group. In administered groups, trabecular bone area (TBA) in the tibia and lumbar were also increased compared with control group in histomorphological analysis. The preventive or treatment effects of Sophorae Fructus extracts on bone loss in OVX rats appears to be due to suppression of bone turnover.

주제어

#Sophorae fructus   #Osteoporosis   #Ovariectomy   #Deoxypyridinoline   #Calcium level   #Trabecular bone area  

저자의 다른 논문

Shim, Jae-Gul(10) Yeom, Seung-Hwan(14) Kim, Hyun-Jung(12) Choi, Young-Wook(73) Lee, Do-Ik(62) 권석형(6) 이민원(67)

참고문헌 (24)

  1. Balbaa, S. I., Zaki, A., Y., and Eln Shamy, A. M., Qualitative and quantitative study of the flavonoid content of the different organs of Sophora japonica at different stages of development. Planta Medica, 25, 325-330 (1974) 
  2. Han, B. H., Takeatsu, K., Paul, P. H. But, Guo, J.-X., and Sung, C. K., International Collation of Traditional and Folk Medicine: Northeast Asia-Part I, World Scientific Publishing Co., Singapore, p.p. 68-69 (1996) 
  3. Hesley, R. P., Shepard, K. A., Henkins, D. K., and Riggs, B. L., Monitoring estrogen replacement therapy and identifying rapid bone losers with an immunoassay for deoxypyridinoline. Osteoporosis int., 8, 159-164 (1998) 
  4. Kariyone, T., Ishimasa, S., and Shiomi, T., Triterpenoids. VIII. Triterpenoids contained in Sophora japonica. Yakugaku Zasshi., 76, 1210-1211 (1956) 
  5. Kim, H. J., Kim, M. G., Shim, J. G., Yeom, S. H., and Lee, M. W., Quantitative Determination of Isoflavonoids and Flavonoids from Sophorae Fructus. Chung-Ang Journal of Pharmacal Sciences, 18, 37-43 (2004) 
  6. Omi, N. and Ezawa, I., The effect of ovariectomy on bone metabolism in rats. Bone, 17, 163S-168S (1995) 
  7. Riggs, B. L., Overview of osteoporosis. West J. Med., 154, 63- 77 (1991) 
  8. Takahashi, M., Ishimasa, S., and Koyama, Y., Components of Sophora japonica. IV. Optical rotary dispersion curve of the derivative of sophoradiol. Yakugaku Zasshi., 80, 698-699 (1960) 
  9. Stark, A. and Madar, Z., Phytoestrogens: a review of recent findings. J. Pediatr. Endocrinol. Metab., 15, 561-572 (2002) 
  10. Kimura, M. and Yamada, H., Interaction in the antibacterial activity of flavonoids from Sophora japonica L. to Propionibacterium. Yakugaku zasshi., 104, 340-346 (1984) 
  11. Setchell, K. D. R., Phytoestrogens: the biochemistry, physiology, and implications for human health of soy isoflavones. AM. J. Clin. Nutr., 68, 1333S-1346S (1998) 
  12. Wang, L.-Q., Mammalian phytoestrogens: enterodiol and enterolactone. J. Chromatoar., B 777, 289-309 (2002) 
  13. Garnero, P. and Delmas, P. D., New developments in biochemical markers for osteoporosis. Calcified tissue international, 59, S2-9, (1996) 
  14. Seyedin, S. M. and Rosen, D. M., Matrix Proteins of the Skeleton. Curr. Opin. Cell Biol., 2, 914-919 (1990) 
  15. Bhathena, S. M. and Velasquez, M. T., Beneficial role of dietary phytoestrogens in obesity and diabetes. AM. J. Clin. Nutr., 76, 1191-1201 (2002) 
  16. Riley, J. P., The use of continuous extraction for the removal of interfering elements in the determination of calcium and magnesium. Analytica Chimica Acta, 21, 317-323 (1959 ) 
  17. Akhmedkhodzhaeva, N. M., Svechnikova, A. N., Bandyukova, V. A., and Kambarova, D. M., Determination of flavones in Sophora japonica fruits. Farmatsiya, 35, 60-61 (1986) 
  18. Genant, H. K., Bay link, D. J., and Gallagher, J. C., Estrogens in the prevention of osteoporosis in post menopausal women. American Journal of Obsteterics and Gynaecology, 161, 1842-1846 (1998) 
  19. Eastell, R., Colwell, A., Hampton, L., and Reeve, J., Biochemical markers of bone resorption compared with estimates of bone resorption from radiotracer kinetic studies in osteoporosis. J. Bone Miner. Res., 12, 59-65 (1997) 
  20. Kim, T. W., The Woody Plants of Korea in Color, Kyo-Hak Publishing Co., Seoul, Korea, p. 399 (1995) 
  21. Belcher, S. M. and Zasrnovszky, A., Estogenic actions in the brain: estrogen, phytoestrogen, and rapid intracellular mechanisms. J. Pharmacol. Exp. Ther., 299, 408-414 (2001) 
  22. Glazier, M. G. and Bowman, M. A., A review of the evidence for the use of phytoestrogens as a replacement for traditional estrogen replacement therapy. Arch. Intern. Med., 161, 1161- 1172 (2001) 
  23. Gruber, H. E., Ivey, J. L., Baylink, D. L., Mathews, M., Nelp, W. B., Sison, K., and Chestnut, C. H., Lomg-term calcitonin therapy in postmenopaual osteoporosis. Metabolism, 33, 295-303 (1984) 
  24. Van Staveren, W. A., de Groot, L. C., Blanco, Y. H., and Van der Wilen, R. P., Assessing diets of elderly people: problems and approaches. Am. J. Clin. Nutr., 59, 2215-2235 (1999) 

이 논문을 인용한 문헌 (4)

  1. Choi, Sun-Eun ; Shim, Jae-Geul ; Oh, Myoeng-Hwan ; Kwon, Suk-Hyung ; Lee, Min-Won 2009. "Anti-hyperlipidemic Effect of Sophorae Fructus on Hyperlipidemic Rat Induced by High Fat-rich Diet" 생약학회지, 40(3): 244~250 
  2. 2010. "" Archives of pharmacal research : a publication of the Pharmaceutical Society of Korea, 33(4): 523~530 
  3. Do, Yoon-Jung ; Ku, Sae-Kwang ; Kim, Hong-Tae ; Oh, Tae-Ho ; Cho, Young-Moo ; Kim, Sung-Woo ; Ryu, Il-Sun ; Lee, Keun-Woo 2011. "Antiosteoporotic Effects of Polygoni Multiflori Radix (PMR) in Ovariectomized (OVX)-Induced Osteoporosis ddY Mice" Journal of veterinary clinics = 한국임상수의학회지, 28(4): 375~386 
  4. Kang, Young-Soon ; Han, Min Ho ; Lee, Moon Hee ; Hong, Su Hyun ; Park, Heungsik ; Jung, Jae-Chul ; Lee, Jeongrai ; Lee, Eun-Woo ; Kang, Kyung Hwa ; Kim, Cheol Min ; Kim, Byung-Woo ; Choi, Yung Hyun 2013. "Fructus Sophorae Enhances the Production of Prostaglandin E2 and Tumor Necrosis Factor-α through Activation of MAPKs and PI3K/AKT Signaling Pathways in Murine Macrophages" 생명과학회지 = Journal of life science, 23(11): 1397~1403 

원문보기

원문 PDF 다운로드

  • ScienceON :

원문 URL 링크

원문 PDF 파일 및 링크정보가 존재하지 않을 경우 KISTI DDS 시스템에서 제공하는 원문복사서비스를 사용할 수 있습니다. (원문복사서비스 안내 바로 가기)

상세조회 0건 원문조회 0건

이 논문과 함께 이용한 콘텐츠

DOI 인용 스타일