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논문 상세정보

Abstract

Nine known diarylheptanoids (1-9) isolated from the barks of Alnus japonica were evaluated for their inhibitory activities on nitric oxide (NO) and prostagrandin $E_2$ (COX-2) production in interferon-${\gamma}$ (INF-${\gamma}$) and lipopolysaccharide (LPS)-activated RAW 264.7 cells in vitro. The NO and COX-2 levels were moderately reduced by the addition of compounds (1-9). Among these compounds, compounds 6 and 8 inhibited NO production in a dose dependent manner with an $IC_{50}$ of 16.7 and $27.2\;{\mu}g/mL$, respectively (positive control, L-NMMA; $22.8\;{\mu}g/mL$), and compounds 6, 7, 8, and 9 reduced the COX-2 level in a dose dependent manner with an $IC_{50}$ of 20.7, 25.7, 25.0, and $27.3\;{\mu}g/mL$, respectively (positive control, indomethacin; $26.2\;{\mu}g/mL$). An analysis of the structural activity relationship among these diarylheptanoids suggests that the presence of a keto-enol group in the heptane moiety or a caffeoyl group in the aromatic ring were important for the efficacy on the inhibitory activities of NO and COX-2 production.

참고문헌 (9)

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이 논문을 인용한 문헌 (6)

  1. Lim, Hyun-Woo ; Shim, Jae-Geul ; Choi, Hyung-Kyoon ; Lee, Min-Won 2005. "Phenolic Compounds from Barks of Actinidia arguta Planchon Growing in Korea and its Anti-Oxidative and Nitric Oxide Production Inhibitory Activities" 생약학회지, 36(3): 245~251 
  2. 2006. "" Natural product sciences, 12(4): 221~225 
  3. 2008. "" Archives of pharmacal research : a publication of the Pharmaceutical Society of Korea, 31(4): 424~428 
  4. 2009. "" Journal of the Korean Society for Applied Biological Chemistry, 52(4): 371~374 
  5. 2010. "" Archives of pharmacal research : a publication of the Pharmaceutical Society of Korea, 33(3): 363~367 
  6. 2011. "" Journal of pharmaceutical investigation, 41(4): 227~232 

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