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논문 상세정보


Nine known diarylheptanoids (1-9) isolated from the barks of Alnus japonica were evaluated for their inhibitory activities on nitric oxide (NO) and prostagrandin $E_2$ (COX-2) production in interferon-${\gamma}$ (INF-${\gamma}$) and lipopolysaccharide (LPS)-activated RAW 264.7 cells in vitro. The NO and COX-2 levels were moderately reduced by the addition of compounds (1-9). Among these compounds, compounds 6 and 8 inhibited NO production in a dose dependent manner with an $IC_{50}$ of 16.7 and $27.2\;{\mu}g/mL$, respectively (positive control, L-NMMA; $22.8\;{\mu}g/mL$), and compounds 6, 7, 8, and 9 reduced the COX-2 level in a dose dependent manner with an $IC_{50}$ of 20.7, 25.7, 25.0, and $27.3\;{\mu}g/mL$, respectively (positive control, indomethacin; $26.2\;{\mu}g/mL$). An analysis of the structural activity relationship among these diarylheptanoids suggests that the presence of a keto-enol group in the heptane moiety or a caffeoyl group in the aromatic ring were important for the efficacy on the inhibitory activities of NO and COX-2 production.

참고문헌 (9)

  1. Jang D. S., Muriel C., Alison D. P., Leonardus B. S. K., Kazuko K., Norman R. F., Harry H. S. F., John M. P., and A. Douglas K., Potential cancer chemopreventive constituents of the leaves of Macaranga triloba. Phytochemistry, 65, 345-350 (2004) 
  2. Rie I., Koichi S., Masakazu H., Takeshi S., Susumu K., and Fumio A., Inhibitory Effects of Hydrolyzable Tannins from Melastoma dodecandrum Lour. On Nitric Oxide Production by a Murine Macrophage-Like cell Line, RAW 264.7, Activated with Lipopolysaccharide and Interferon-$\gamma$. Biol. Pharm. Bull., 22, 647-653 (1999) 
  3. Subbaramiah K., Telang N., Ramonetti J. T., Araki T., DeVito B., Weksler B. B., and Dannenberg A. J., Transcription of cyclooxygenase-2 is enhanced in transformed mammary epithelial cells. Cancer Res., 56, 4424-4429 (1996) 
  4. Kim, H. J., Kim, K. H., Yeom, S. H., Kim, M. K., Shim, J. G., and Lee M. W., New Diarylheptanoid from the Barks of Alnus japonica steudel. Chinese Chem. Lett., submitted (2004) 
  5. Je K. H., Jan A. R., Lee H. T., Mar W. C., and Seo E. K., The inhibitory Principle of lipopolysaccharide-Induced Nitric Oxide Production from Inula britannica var. chinensis. Arch. Pharm.Res., 27, 83-85 (2004) 
  6. Moncada S., Palmer R. M., and Higgs E. A., Nitric oxide: physiology, pathophysiology, and pharmacology. Pharmacol. Rev., 43, 1091-1042 (1991) 
  7. Mosmann, T., Rapid colorimetric assay for cellular growth and survival: application to proliferation and cytotoxic assays. J. Iimmunol. Methods., 65, 55-63 (1983) 
  8. Lee, M. W., Kim J. H., Jeong, D. W., Ahn, K. H., Toh, S. H., and Surh, Y. J., Inhibition of Cyclooxygenase-2 Expression by Diarylheptanoids from the Bark of Alnus hirsuta var. sibirica. Biol. Pharm. Bull., 23, 517-518 (2000) 
  9. Lee, M. W., Kim N. Y., Park. M. S., Ahn, K. H., Toh, S. H., Hahn, D. R., Kim, Y. C., and Chung, J. T., Diarylheptanoids with In vitro inducible nitric oxide synthesis inhibitory activity from Alnus hirsuta. Planta Med., 66, 551-553 (2000) 

이 논문을 인용한 문헌 (6)

  1. Lim, Hyun-Woo ; Shim, Jae-Geul ; Choi, Hyung-Kyoon ; Lee, Min-Won 2005. "Phenolic Compounds from Barks of Actinidia arguta Planchon Growing in Korea and its Anti-Oxidative and Nitric Oxide Production Inhibitory Activities" 생약학회지, 36(3): 245~251 
  2. 2006. "" Natural product sciences, 12(4): 221~225 
  3. 2008. "" Archives of pharmacal research : a publication of the Pharmaceutical Society of Korea, 31(4): 424~428 
  4. 2009. "" Journal of the Korean Society for Applied Biological Chemistry, 52(4): 371~374 
  5. 2010. "" Archives of pharmacal research : a publication of the Pharmaceutical Society of Korea, 33(3): 363~367 
  6. 2011. "" Journal of pharmaceutical investigation, 41(4): 227~232 


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