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논문 상세정보


The last two decades have shown a marked expansion in publications of diverse effects of Panax ginseng. Ginsenosides, as active ingredients of Panax ginseng, are saponins found in only ginseng. Recently, a line of evidences shows that ginsenosides regulate various types of ion channel activity such as $Ca^{2+},\;K^+,\;Na^+,\;Cl^-$, or ligand gated ion channels (i.e. $5-HT_3$, nicotinic acetylcholine, or NMDA receptor) in neuronal, non-neuronal cells, and heterologously expressed cells. Ginsenosides inhibit voltage-dependent $Ca^{2+},\;K^+,\;and\;Na^+$ channels, whereas ginsenosides activate $Ca^{2+}-activated\;Cl^-\;and\;Ca^{2+}-activated\;K^+$ channels. Ginsenosides also inhibit excitatory ligand-gated ion channels such as $5-HT_3$, nicotinic acetylcholine, and NMDA receptors. This review will introduce recent findings on the ginsenoside-induced differential regulations of ion channel activities and will further expand the possibilities how these ginsenoside-induced ion channel regulations are coupled to biological effects of Panax ginseng.

참고문헌 (40)

  1. Tyler, V. E. : Herbal remedies. J Pharm Technol 11, 214-220 (1995) 
  2. Nah, S. Y. : Ginseng; Recent advances and Trends. J. Ginseng Res. 21, 1-12 (1997) 
  3. Nah, S. Y., Park, H. J. and McCleskey, E.W. : A trace component of ginseng that inhibit $Ca^{2+}$ channels through a pertussis toxin-sensitive G protein. Proc Natl Acad Sci USA 92, 8739-8743 (1995) 
  4. Rhim, H., Kim, H., Lee, D. Y., Oh, T. H. and Nab, S. Y. : Ginseng and ginsenoside $Rg_3$, a newly identified active ingredient of ginseng, modulate $Ca^{2+}$ channel currents in rat sensory neurons. Eur. J. Pharmacol. 436, 151-158 (2002) 
  5. Miller, R. J. : Rocking and rolling with $Ca^{2+}$ channels. Trends in Neurosci. 24, 445-449 (2001) 
  6. Nah, S.Y. and McCleskey, E. W. : Ginseng root extract inhibits calcium channels in rat sensory neurons through a similar path, but different receptor, as m-type opioids. J Ethnopharmacol 42, 45-51 (1994) 
  7. Kim, H. S., Lee, J. H., Koo, Y. S. and Nab, S. Y. : Effects of ginsenosides on $Ca^{2+}$ channels and membrane capacitance in rat adrenal chromaffin cells. Brain Res Bull. 46, 245-251 (1998) 
  8. Choi, S., Jung, S. Y., Kim, C. H., Kim, H. S., Rhim, H., Kim, S. C. and Nah, S. Y. : Effect of ginsenosides on voltagedependent $Ca^{2+}$ channel subtypes in bovine chromaffin cells. J. Ethnopharmacol. 74, 75-81 (2001) 
  9. Wickman, K. D. and Clapham, D. E. : G-protein regulation of ion channels. Current Opinion in Neurobiology 5, 278-285 (1995) 
  10. Chung, I. and Kim, N. D. : Ginseng saponins enhance maxi $Ca^{2+}$ -activated $K^+$ currents of the rabbit coronary artery smooth muscle cells. J. Ginseng Res. 23, 230-234 (1999) 
  11. Chung, I. and Lee, J. S. : Ginsenoside $Rg_3$ increases the ATPsensitive $K^+$ channel activity in the smooth muscle of the rabbit coronary artery. J. Ginseng Res. 23, 235-238 (1999) 
  12. Li, Z., Chen, X., Niwa, Y., Sakamoto, S. and Nakaya, Y. : Involvement of $Ca^{2+}$-activated $K^+$ channels in ginsenosidesinduced aortic relaxation in rats. J.Cardiovasc. Pharmacol. 37,41-47 (2001) 
  13. Jeong, S. M., Lee, J. H., Kim, J. H., Lee, B. H., Yoon, I. S., Lee, J. H., Kim, D. H., Rhim, H., Kim, Y. and Nah, S. Y. : Stereospecificity of ginsenoside $Rg_3$ action on ion channels. Mol. Cells 18, 383-389 (2004) 
  14. Liu, D., Li., B., Liu, Y, Attele, A.S., Kyle, J. W. and Yuan, C. S. : Voltage-dependent inhibition of brain $Na^+$ channels by American ginseng. Eur. J. Pharmacol. 413, 47-54 (2001) 
  15. Lindstrom, J. : Nicotinic acetylcholine receptors. p153-175. In: North, A (ed), CRC Handbook of Receptors. CRC Press, Florida (1995) 
  16. Sargent, P. B. : The diversity of neuronal nicotinic acetylcholine receptor. Ann. Rev. Neurosci. 16,403-443 (1993) 
  17. Tachikawa, E., Kudo, T., Kashimoto, T. and Takashshi, E. : Ginseng saponins reduce acetylcholine-evoked $Na^+$ influx and catecholamine secretion in bovine adrenal chromaffin cells. J Pharmacol Exp Ther. 273, 629-636 (1995) 
  18. Campos-Caro, A., Smillie, E. I., Del Toro, E. D., Rovira, J. C., Vicente-Agullo, E., Chapuli, J., Juiz, J. M., Sala, S., Sala, E., Ballesta, J. and Criado, M.: Neuronal nicotinic acetylcholine receptors on bovine chromaffin cells: cloning, expression, and genomic organization of receptor subunits. J. Neurochem. 68,488-497 (1997) 
  19. Choi, S., Jung, S. Y, Lee, J. H., Sala, E., Criado, M., Mulet, J., Valor L. M., Sala, S., Engel, A. G. and Nah, S. Y.: Effects of ginsenosides, active components of ginseng, on nicotinic acetylcholine receptors expressed in Xenopus oocytes. Eur. J. Pharmacol. 442, 37-45 (2002) 
  20. Sala, F., Mulet, J., Choi, S., Jung, S. Y., Nah, S. Y., Rhim, H., Valor, L. M., Criado, M. and Sala, S. : Effects of ginsenoside $Rg_2$ on human neurona nicotinic acetylcholine receptors. J. Pharm. Exp. Ther. 301, 1052-1059 (2002) 
  21. Choi, S., Lee, J. H., Oh, S., Rhim, H., Lee, S. M. and Nah, S. Y. : Effects of ginsenoside $Rg_2$ on the 5-$HT_3$ receptor-mediated ion current in Xenopus oocytes. Mol. Cells 15, 108-113 (2003) 
  22. Lee, B. H., Jeong, S. M., Lee, J. H., Kim, D. H., Kim, J. H., Kim, J. I., Shin, H. C, Lee, S. M. and Nah, S. Y : Differential effect of ginsenoside metabolites on the 5-$HT_{3A}$ receptor-mediated ion current in Xenopus oocytes. Mol. Cells 17, 51-56 (2004) 
  23. Dingledine, R., Borges, K., Bowie, D. and Traynelis, S. E : Glutamate receptor ion channels. Pharmacol. Rev. 51, 7-62 (1999) 
  24. Kim, Y. C, Kim, S. R., Markelonis, G. J. and Oh, T. H. : Ginsenosides $Rb_1$and $Rg_3$ protect cultured rat cortical cells from glutamate-induced neurodegeranation. J. Neurosci. Res.53.426-432 (1998) 
  25. Seong, Y. H., Shin, C S., Kim, H. S. and Baba, A. : Inhibitory effect of ginseng total saponins on glutamate-induced swelling of cultured atrocytes. Biol. Pharm.Bull. 18, 1776-1778 (1995) 
  26. Abe, K., Cho, S. I., Kitagawa, I., Nishiyama, N. and Saito, H. : Differential effects of ginsenoside $Rb_1$ and malonylginsenoside $Rb_1$ on long-term potentiation in the dentate gyrus of rats. Brain Res. 649, 7-11 (1994) 
  27. Yoon, S. R., Nah, J. J., Shin, Y. H., Kim, S. K., Nam, K. Y., Choi, H. S. and Nah, S. Y. : Ginsenosides induce differential antinocicepion and inhibit substance P induced-nociceptive response in mice. Life Sci. 62, PL319-PL325 (1998) 
  28. Nah, J. J., Choi, S., Kim, Y. H., Kim, S. C, Nam, K. Y., Kim, J. K. and Nah, S. Y. : Effect of spinally administered ginseng total saponin on capsaicin-induced pain and excitatory amino acid-induced nociceptive responses. J. Ginseng Res. 23, 38-43 (1999) 
  29. Kim, S., Ahn, K., Oh, T. H., Nah, S. Y. and Rhim, H. : Inhibitory effect of ginsenosides on NMDA receptor-mediated signals in rat hippocampal neurons. Biochem Biophys Res Commun. 296, 247-254 (2002) 
  30. Hong, H.Y., Yoo, G. S. and Choi, J. K. : Effects of ginsenosides on pp60c- sre kinase, intracellular calcium and cell proliferation in NIH 3T3 cells. J Ginseng Res 22, 126-132 (1998) 
  31. Choi, S., Rho, S. H., Jung, S. Y., Kim, S. C., Park, C. S. and Nah, S. Y. : A novel activation of $Ca^{2+}$-activated $CI^-$ channel in Xenopus oocytes by ginseng saponins: evidence for the involvement of phospholipase C and intracellular $Ca^{2+}$ mobilization. British J. Pharmacol. 132, 641-648 (2001) 
  32. Jeong, S. M., Lee, J. H., Kim, S., Rhim, H., Lee, R.H., Kim, J. H., Oh, J. W., Lee, S. M. and Nah, S. Y. : Ginseng saponins induce store-operated calcium entry in Xenopus oocytes. Br. J. Pharmacol. 142, 585-593 (2004) 
  33. Berridge, M. J., Bootman, M. D. and Lipp, P. : Calcium - a life and death signal. Nature, 395, 645-668 (1998) 
  34. Choi, S., Jung, S. Y., Ko, Y. S., Koh, S. R., Rhim, H. and Nah, S. Y. : Functional Expression of a novel ginsenoside Rf binding protein from rat brain mRNA in Xenopus oocytes. Mol. Pharmacol. 61, 928-935 (2002) 
  35. Shin, E. K., Park, H. W., Kim, S. C. and Jung, N. P. : The effect of ginseng components on the signal transduction in the activation of murine macrophages. Kor J Ginseng Sci 20, 159-167 (1996) 
  36. Choi, S., Kim, H. J., Ko, Y. S., Jeong, S. W., Kim, Y. I., Simonds, W. E, Oh, j. W. and Nab, S. Y. :$G{\alpha}_{q/11}$ coupled to mammalian PLC$\beta$3-like enzyme mediates the ginsenoside effect on $Ca^{2+}$ -activated CJ current in the Xenopus oocyte. J. Biol. Chem. 276, 48797-48802 (2001) 
  37. Kim, N. K., Kang, S. Y., Park, J. H. and Schini-Kerth, V. B. : Ginsenoside $Rg_3$ mediates endothelium-dependent relaxation in response to ginsenosides in rat aorta: role of $K^+$ channels. Eur. J. Pharmacol. 367, 41-49 (1999) 
  38. Dascal, N. : Signaling via the G prorein-activated $K^+$ channels. Cell Signal. 9,551-573 (1997) 
  39. Maricq, A. V., Peterson, A. S., Brake, A. J., Myers, R. M. and Julius, D. : Primary structure and functional expression of the 5-$HT_3$ receptor, a serotonin-gated ion channel. Science, 254, 432-437 (1991) 
  40. Lee, J. H., Kim, S. H., Kim, D., Hong, H. N. and Nah, S. Y. : Protective effect of ginsenosides, active ingredients of Panax ginseng, on kainate-induced neurotoxicity in rat hippocam- pus. Neurosci. Lett. 325, 129-133 (2001) 

이 논문을 인용한 문헌 (4)

  1. 2006. "" Journal of ginseng research = 高麗人參學會誌, 30(2): 57~63 
  2. 2009. "" Journal of ginseng research = 高麗人參學會誌, 33(4): 294~304 
  3. 2010. "" Journal of ginseng research = 高麗人參學會誌, 34(3): 246~253 
  4. 2014. "" Journal of ginseng research = 高麗人參學會誌, 38(1): 1~7 


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