[논문]Comparison of Cytotoxic Activities between in Vitro and Field Grown Plants of Typhonium flagelliforme (Lodd.) Blume

Chan Lai Keng; Koh Wan Yee; Tengku-Muhammad Tengku S.

doi:10.1007/bf03030561

Comparison of Cytotoxic Activities between in Vitro and Field Grown Plants of Typhonium flagelliforme (Lodd.) Blume

Journal of plant biology = 식물학회지, v.48 no.1, 2005년, pp.25 - 31

Chan Lai Keng (School of Biological Sciences, Universiti Sains Malaysia) , Koh Wan Yee (School of Biological Sciences, Universiti Sains Malaysia) , Tengku-Muhammad Tengku S. (School of Biological Sciences, Universiti Sains Malaysia)

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An in vitro cytotoxicity screening of the Typhonium flagelliforme extracts indicated high cytotoxicity effect on human lung carcinoma NCI-H23 cells and human mammary gland carcinoma T-47D cells, but the extracts were not active on human liver carcinoma HepG2 cells. NCI-H23 cells were more susceptible to T. flagelliforme extracts than T-47D cells. $EO_{50}$ values of the hexane fractions of the mature plant and the in vitro plantlet of T. flagelliforme on NCI-H23 cells were less than $2{\mu}g/mL$. Extract from the mature plant was relatively more cytotoxic than the one from in vitro plantlet except for the hexane fraction. The chloroform and butanol fraction of the mature plant had higher cytotoxicity effect than the fraction from in vitro plantlet on NCI-H23 cells. All the 3 fractions (hexane, chloroform, and butanol) of the mature plant exhibited higher cytotoxicity effects on human mammary gland carcinoma T-47D cells than the 3 fractions of in vitro plantlet. However, the human liver carcinoma cells were resistant to T. flagelliforme extracts except for higher concentration of hexane fractions of both the mature and the in vitro plants and the chloroform fraction of the mature plant. Micropropagated plantlets of T. flagelliforme could hence be used as herbal materials for the treatment of human lung and breast cancers.

참고문헌 (21)

J Ethnopharmacol CY Choo 77 129 2001 10.1016/S0378-8741(01)00274-4 Choo CY, Chan KL, Sam TW, Hitotsuyanagi Y, Takeya K (2001) The cytotoxicity chemical constituents of the hexane fraction ofTyphonium flagelliforme (Araceae). J Ethnopharmacol 77: 129-131

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Acta Cient Venez T Colman de Saizarbitoria 48 42 1997 Colman de Saizarbitoria T, Anderson JE, Alfonso D, McLaughlin JL (1997) Bioactive furonaphtoquinones fromTabebuia barbata (Bignoniaceae). Acta Cient Venez 48: 42-46

상세보기
C Dennis 2001 Antioxidant studies onTyphonium flagelliforme (mother plant),T flagelliforme (in vitro) andAndrographis paniculata (mother plant) Dennis C (2001) Antioxidant studies onTyphonium flagelliforme (mother plant),T flagelliforme (in vitro) andAndrographis paniculata (mother plant). Thesis of Applied Science Degree. Universiti Sains, Penang
Cancer Chem Rep Rl Geran 3 1 1972 Geran Rl, Greenberg NH, Macdonald MM (1972) Protocols for screening chemical agents and natural products against animal tumours and other biological systems. Cancer Chem Rep 3: 1-87
SH Goh 1993 Phytochemical guide to Malaysia flora. Institute of advanced studies Goh SH, Soepadmo E, Chuah CH (1993) Phytochemical guide to Malaysia flora. Institute of advanced studies, University of Malaya, Kuala Lumpur
Phytochem M Hamburger 30 3864 1991 10.1016/0031-9422(91)83425-K Hamburger M, Hostettmann K (1991) Bioactivity in plants: the link between phytochemistry and medicine. Phytochem 30: 3864-3874

상세보기
Blumea A Hay 37 345 1993 Hay A (1993) The genusTyphonium (Araceae-areae) in Australia. Blumea 37: 345-376
Cancer Invest CK Ho 21 729 2003 10.1081/CNV-120023771 Ho CK, Chan CC (2003) Moscatilin from the orchidDendrobrium loddigesii is a potential anticancer agent. Cancer Invest 21: 729-736

상세보기
K Hostettmann 1995 10.1017/CBO9780511565113 Saponins Hostettmann K, Marston A (1995) Saponins. Cambridge University Press, London
Heterocycles H Itokawa 35 1467 1993 10.3987/REV-92-SR(T)7 Itokawa H, Takaya K (1993) A review of antitumor substances from higher plants. Heterocycles 35: 1467

상세보기
J Trap Med Plants WY Koh 4 91 2003 Koh WY, Chan LK (2003) Micropropagation ofTyphonium flagelliforme in immersion cultures. J Trap Med Plants 4: 91-96
Yao Xue Xue Bao J Li 33 641 1998 Li J, Liang N, Mo L, Zhang X, He C (1998) Comparison of the cytotoxicity of five constituents fromPteris semipinnata L.in vitro and the analysis of their structure-activity relationships. Yao Xue Xue Bao 33: 641-644 (article in Chinese)
Physiol Plant T Murashige 15 473 1962 10.1111/j.1399-3054.1962.tb08052.x Murashige T, Skoog F (1962) A revised medium for rapid growth and bioassays with tobacco tissue cultures. Physiol Plant 15: 473-497

상세보기
Med J Malaysia CK Neoh 47 86 1992 Neoh CK (1992)Typhonium divaricatum (rodent tubers): A promising local plant in the fight against cancer. Med J Malaysia 47: 86-88

상세보기
BP Ong 1996 Micropropagation and bioactivities study ofTyphonium flagelliforme. Thesis of Applied Science Degree Ong BP (1996) Micropropagation and bioactivities study ofTyphonium flagelliforme. Thesis of Applied Science Degree. Univeristi Sains, Penang
Perry MR Metzger J (1980) Medicinal Plants of East and Southeast Asia: Attributed Properties and Uses. MIT Press, London, pp 39
In Vitro Cell Dev Biol TS Su 36 402 2000 10.1007/s11627-000-0072-9 Su TS, Chan LK, Pargini N, Teo CKH (2000)In vitro propagation ofTyphonium flagelliforme (Lodd) Blumea.In Vitro Cell Dev Biol 36: 402-406

상세보기
Tan ML (2003) Cytotoxicity and cell death mechanisms ofEpipremnum pinnatum (L.) Engl, extracts in T-47D, a breast carcinoma cell line. Ph.D. thesis, Universiti Sains, Penang
Teo CKH, Chng Bl (1996) Cancer: Yet they livel Eramaps Sdn Bhd, Malaysia, pp 53-70
K Thilakavathy 157 1999 Interdisciplinary Approaches in Natural Product Sciences Thilakavathy K, Maznah I, Asmah R, Siti MM, Asmah Y, Fauziah O (1999) The Effect ofTyphonium divaricatum extract on the plasma gamma-glutamyl transpeptidase and the histology of induced hepatocarcinogenesis rat liver.In Z Zakaria, Nl Yusoff, IM Said, LB Din, eds, Interdisciplinary Approaches in Natural Product Sciences. The Malaysian Natural Products Society, Kuala Lumpur, pp 157-163
Jap J Med Sci Biol S Yamazaki 39 105 1986 10.7883/yoken1952.39.105 Yamazaki S, Onishi E, Enami K, Kohase M, Sakamoto H, Tanouchi M, Hayashi H (1986) Proposal of standardized methods and reference for assaying recombinant human tumour necrosis factor. Jap J Med Sci Biol 39: 105-118

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표제어: PCR

동의어: Packet Collision Rate

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Comparison of Cytotoxic Activities between in Vitro and Field Grown Plants of Typhonium flagelliforme (Lodd.) Blume

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참고문헌 (21)

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