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논문 상세정보

9종의 허브류로부터 ACE 저해활성, HMG-CoA reductase 저해활성 및 혈전용해활성에 대한 검색

Screening of Nine Herbs with Biological Activities on ACE Inhibition, HMG-CoA Reductase Inhibition, and Fibrinolysis

초록

본 연구는 혈액순환 개선 효능을 알아보기 위해 민간에서 빈번하게 사용하는 허브류인 마조람, 라벤더, 딜, 로즈마리, 히솝, 장미, 레몬밤, 파인애플 세이지 및 에키네시아 등 총 9종 을 실험 시료로 선정하였다. 이들을 부위별 및 용매별로 추출하여 angiotensin I converting enzyme(ACE) 저해 활성, hydroxy-methylglutalyl coenzyme A reductase 저해활성 및 혈전용해활성을 측정하였다. 추출 수율은 장미꽃이 가장 높았으며 열수 추출의 경우 43.3%였고 70% 에탄올 추출의 경우 45%였다. ACE 저해활성은 열수 추출의 경우 장미꽃이 133.8% 로 가장 높았고 70% 에탄올 추출의 경우에는 파인애플 세이지 잎이 91.2%로 가장 높았다. HMG-CoA reductase 저해활성의 경우에는 장미꽃이 열수 추출물 48.9%, 70% 에탄올 추출물 80.5%로 모두 높았다. 혈전용해활성도 장미꽃에서 열수 추출이나 에탄올 추출물 모두 가장 높은 활성을 보였다. 이상의 결과로 볼 때 장미꽃 추출물의 혈액순환 개선 효과가 뛰어난 것으로 나타나 기능성 식품으로의 개발 가능성이 기대된다.

Abstract

The purpose of this study was to investigate how herb extracts may improve blood circulation. Twenty-six extracts from nine different herbs (marjoram, lavender, dill, rosemary, hyssop, rose, lemon balm, pineapple sage, and echinacea) were evaluated for their anti-hypertensive effects via angiotensin I converting enzyme (ACE) inhibition. Their cholesterol-lowering effects via hydroxy-methyl-glutaryl coenzyme A (HMG-CoA) reductase inhibition and their fibrinolytic activity via fibrin-plate method were also evaluated. Both water extraction of rose flowers and 70% EtOH extraction of pineapple sage leaves effectively reduced the ACE activity with inhibition rates of 133.8% and 91.2%, respectively. Similarly, both water and 70% EtOH extracts of rose flowers strongly inhibited the enzymatic activity of HMG-CoA reductase by 48.9% and 80.5%, respectively. Water and 70% EtOH extracts of rose flowers also showed relatively high fibrinolytic activity. Based on these observations, rose flower extracts can be developed as a functional tool for use in the improvement of blood circulation.

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이 논문을 인용한 문헌 (10)

  1. Lee, Joon-Seol ; Park, Yang-Kyun ; Ahn, Young-Sup ; Kim, Hag-Sin ; Chung, Mi-Nam ; Jeong, Byeong-Choon ; Bang, Jin-Ki 2007. "Antioxidative and Biological Activites of Extracts of Sweetpotato Tips" Korean journal of crop science = 韓國作物學會誌, 52(4): 411~420 
  2. Lee, Joon-Seol ; Park, Yang-Kyun ; Ahn, Young-Sup ; Kim, Hag-Sin ; Chung, Mi-Nam ; Jeong, Byeong-Choon ; Bang, Jin-Ki 2007. "Antioxidative and Biological Activites of Extracts of Sweetpotato Tips" Korean journal of crop science = 韓國作物學會誌, 52(2): 228~238 
  3. Oh, Soon-Ja ; Hong, Sung-Soo ; Kim, Yeon-Hee ; Koh, Seok-Chan 2008. "Screening of Biological Activities in Fern Plants Native to Jeju Island" 韓國資源植物學會誌 = Korean journal of plant resources, 21(1): 12~18 
  4. Ha, Jin-Ok ; Ha, Tae-Man ; Lee, Jae-Joon ; Kim, Ah-Ra ; Lee, Myung-Yul 2009. "Chemical Components and Physiological Functionalities of Brassica campestris ssp rapa Sprouts" 한국식품영양과학회지 = Journal of the Korean Society of Food Science and Nutrition, 38(10): 1302~1309 
  5. Kang, Byung-Sun ; Moon, Sung-Won 2010. "Effect of Rosemary Powder on the Sensory Characteristics and Color of Sponge Cake during Storage" 한국식품저장유통학회지 = Korean journal of food preservation, 17(1): 9~15 
  6. Hwang, In-Guk ; Kim, Hyun-Young ; Shin, So-Lim ; Lee, Cheol-Hee ; Lee, Jun-Soo ; Jang, Keum-Il ; Jeong, Heon-Sang 2010. "Biological Activities of Coreopsis tinctoria Nutt. Flower Extracts" 원예과학기술지 = Korean journal of horticultural science & technology, 28(5): 857~863 
  7. Kim, Hyun-Young ; Hwang, In-Guk ; Kim, Tae-Myoung ; Park, Dong-Sik ; Kim, Jae-Hyun ; Kim, Dae-Joong ; Lee, Jun-Soo ; Jeong, Heon-Sang 2011. "Antioxidant and Angiotensin Converting Enzyme I Inhibitory Activity on Different Parts of Germinated Rough Rice" 한국식품영양과학회지 = Journal of the Korean Society of Food Science and Nutrition, 40(6): 775~780 
  8. Son, Jong-Youn ; Kim, Tai-Ok 2011. "Antioxidative and Physiological Activities of Traditional Korean Teas" 한국식품조리과학회지 = Korean Journal of Food & Cookery Science, 27(5): 567~575 
  9. Kim, Min Young ; Lee, Sang Hoon ; Jang, Gwi Young ; Park, Hye Jin ; Meishan, Li ; Kim, Shinje ; Lee, Youn Ri ; Lee, Junsoo ; Jeong, Heon Sang 2013. "Enzyme Inhibition Activities of Ethanol Extracts from Germinating Rough Rice (Oryza sativar L.)" 한국식품영양과학회지 = Journal of the Korean Society of Food Science and Nutrition, 42(6): 917~923 
  10. Kim, Min Young ; Lee, Sang Hoon ; Jang, Gwi Young ; Park, Hye Jin ; Li, Meishan ; Kim, Shinje ; Lee, Youn Ri ; Lee, Junsoo ; Jeong, Heon Sang 2014. "The Enzyme Inhibitory Activity of Ethanol Extracts Derived from Germinated Rough Rice (Oryza sativar L.) Treated by High Pressure" 한국식품과학회지 = Korean journal of food science and technology, 46(1): 44~50 

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