In this research, we propose a hybrid inference architecture for medical diagnosis based on dynamic knowledge map (DKM) and relational database (RDB). Conventional expert systems (ES) and developing tools of ES has some limitations such as, 1) time consumption to extend the knowledge base (KB), 2) difficulty to change the inference path, 3) inflexible use of inference functions and operators. To overcome these Limitations, we use DKM in extracting the complex relationships and causal rules from human expert and other knowledge resources. The DKM also can help the knowledge engineers to change the inference path rapidly and easily. Then, RDB and its management systems help us to transform the relationships from diagram to relational table.