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논문 상세정보

고지방식이로 유도된 고지혈증 모델 흰쥐에서 지방과 제니스테인 섭취가 지질대사 및 항산화능에 미치는 영향

Effect of Dietary Fat and Genistein on Lipid Metabolism and Antioxidant Activity in Hyperlipidemic Male Rats induced High Fat Diet


This study was conducted to investigate whether dietary factors, normal fat and genistein leads to beneficial improvement of lipid metabolism and oxidative stress in adult hyperlipidemic male rats. Seven wk-old male SD rats were fed high fat diet (15% fat, 1% cholesterol) for 4 wks for induction of hyperlipidemic model rat. Weight-matched rats were then assigned to four groups according to dietary fat level (7% or 15% fat) and genistein contents (0 or 320 mg/kg diet). Food intake was significantly decreased by both high fat intake and genistein supplementation compared with normal fat intake and genistein no supplementaion. But weight gain was significantly decreased by genistein supplementation in normal fat intake compared with the other groups. Total lipid, total cholesterol and triglyceride in serum and liver were significantly decreased by normal fat intake compared with high fat intake. But total cholesterol in liver was significantly increased by genistein supplementation in both high fat and normal fat intake. TBARS in serum and liver was less produced by normal fat intake compared with high fat intake but TBARS in liver was significantly increased by genistein supplementation compared with genistein no supplementation in normal fat intake. Glutathione reductase activity in erythrocytes was significantly reduced by genistein supplementation in normal fat intake compared with the other groups. Glutathione peroxidase and glutathione reductase activities in liver were significantly inhibited by normal fat intake compared with high fat intake. Catalase activity in liver was significantly increased by genistein supplementation compared with genistein no supplementation in high fat intake. Nitrite was significantly decreased by normal fat intake compared with high fat intake. These results suggest that normal fat intake has the treatment effect against risk factors related with cardiovascular disease by reducing lipid profiles, lipid peroxidation. And genistein shows action as a antioxidant replacing antioxidant enzymes but also may act as prooxidant causing the production of TBARS.

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이 논문을 인용한 문헌 (7)

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  2. Cho, Hwa-Eun ; Choi, Yun-Hee ; Park, Sung-Hye ; Park, Yong-Soo ; Ahn, Byung-Yong 2008. "Effect of Gastrodiae rhizoma Powder on Serum and Liver Lipid Levels of Rats with High Fat Diet" 한국식품영양학회지 = The Korean journal of food and nutrition, 21(1): 64~70 
  3. Lim, Ae-Kyung ; Jung, Mee-Jung ; Kim, Dong-Woo ; Hong, Joo-Heon ; Jung, Hee-Kyoung ; Kim, Kil-Soo ; Kim, Yong-Hae ; Kim, Dae-Ik 2009. "An Extrapolation Concentration Decision Effect Antihyperlipidemic of Aglycone Isoflavone from Biotransformation Soybean on the Fed High-Fat Diet Rats" 한국식품영양과학회지 = Journal of the Korean Society of Food Science and Nutrition, 38(9): 1167~1173 
  4. Park, Young-Sook 2010. "Antioxidant Effects and Improvement of Lipid Metabolism of Acanthopanacis cortex Water Extract in Rats Fed High Fat Diet" 東아시아食生活學會誌 = Journal of the East Asian Society of Dietary Life, 20(1): 37~45 
  5. Roh, Seung-Won ; Kim, Jeung-Beum 2010. "Effects of Mageum-tang on the Hyperlipidemia in Rats" 동의생리병리학회지 = Journal of physiology & pathology in Korean Medicine, 24(2): 319~327 
  6. Ha, Tae-Hoon ; Kim, Hyun-Young ; Kim, Hyung-Woo ; Cho, Su-In ; Kim, Young-Gyun 2012. "Effects of Tong Xin Lou (TXL) on levels of serum lipid in high fat diet-induced dyslipidemia in mice" 大韓本草學會誌 = The Korea journal of herbology, 27(3): 107~112 
  7. Kang, Seong-Sun ; Shin, Yong-Jin ; Jo, Jae-Joon ; Jeon, Sang-Yun 2014. "Study of the Effects of Samulhwalhyeol-tang in Hyperlipidemic Animal Model Induced with a High-Fat Diet" 대한한방내과학회지 = The journal of internal Korean medicine, 35(2): 119~132 

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