• 검색어에 아래의 연산자를 사용하시면 더 정확한 검색결과를 얻을 수 있습니다.
  • 검색연산자
검색연산자 기능 검색시 예
() 우선순위가 가장 높은 연산자 예1) (나노 (기계 | machine))
공백 두 개의 검색어(식)을 모두 포함하고 있는 문서 검색 예1) (나노 기계)
예2) 나노 장영실
| 두 개의 검색어(식) 중 하나 이상 포함하고 있는 문서 검색 예1) (줄기세포 | 면역)
예2) 줄기세포 | 장영실
! NOT 이후에 있는 검색어가 포함된 문서는 제외 예1) (황금 !백금)
예2) !image
* 검색어의 *란에 0개 이상의 임의의 문자가 포함된 문서 검색 예) semi*
"" 따옴표 내의 구문과 완전히 일치하는 문서만 검색 예) "Transform and Quantization"
쳇봇 이모티콘
ScienceON 챗봇입니다.
궁금한 것은 저에게 물어봐주세요.

논문 상세정보


Alcoholism and alcohol abuse are major public health concerns. This is linked to the injury of many organs, especially liver. Experiments were peformed to know the acute effects of LeeKwaDoo (LKD) induced by two-third partial hepatectomy (PH) in rats. In liver samples, regeneration parameters and histological assessment were performed. For the blood biochemical study, the blood were assayed with AST, ALT. The portal branch of liver lobes was ligated in the male Sprague-Dowley rats, two-thirds partial hepatectomies were also performed. It was estimated bodyweight and relative liver weight for the index of liver mass. For the marker of blood chemistry, we investigate the serum sample of rats and demonstrated the level of AST, ALT. Remaining tissues of liver developed as microscopic structures. Resection of the lobes in PH+LKD group resulted in a marked change of liver weight, blood chemistry and histological changes. The initiation of the proliferative response in PH group stimulated as well as reduction of the liver mass. On the other hands, the Initiation of the proliferative response in PH+LKD group delayed. Eventually, both PH group and PH+LKD group was restored relative liver weigh after 7 day. In conclusion, the acute adminstration of LKD seems to inhibit the initial response of liver regeneration through alcohol effects.

참고문헌 (18)

  1. Channareddy S, Nguyen NT, Janes N. 2000. Saturable ethanol binding in rat liver mitochondria. Bioch Biophys Acta 1463(2):291-300 
  2. Jose SG, Luis MG, Elizabeth TI, et al. 1999. Redox state and energy metabolism during liver regeneration. Biochem Pharmacol 58:1831-1839 
  3. Jose GS, Alberto AF, Rodolfo PD, et al. 1996. A possible model to study ethanol-induced inhibition of liver regeneration. Int J Biochem Cell Biol 28:1007-1016 
  4. Anna DM. 1999. Effect of ethanol on tumor necrosis factor signaling during liver regeneration. Clin Biochem 32:571-578 
  5. Higgins DM, Anderson RM. 1931. Experimental pathology of the liver, restoration of the white tat following partial surgical removal. Arch Pathol 12:186-202 
  6. Luc L, Bo L, Isabelle L, et al. 2000. The compensatory hyperplasia (liver regeneration) following ligation of a portal branch is initiated before the atrophy of the deprived lobed. Hepatology J. 32:940-945 
  7. Block GD, Locker JL, Bowen WC, et al. 1996. Population expansion, clonal growth, and specific differentiation patterns in primary cultures of hepatocytes induced by HGF/SF, EGF and TGF $\alpha$ in a chemically defined(HGM) medium. J Cell Biol 132:1133-1149 
  8. Appasamy R, Tanabe M, Murase N, et al. 1993. Hepatocyte growth factor, blood clearance, organ uptake, and biliary excretion in normal and partially hepatectomized rats. J Invest 68:270-276 
  9. Schmidt C, Bladt F, Goedecke S, et al. 1995. Scatter factor/hepatocyte growth factor is essential for liver development. Nature 373:699-702 
  10. Gherardi E. 1990. Hepatocytes and scatter factor. Nature 346:228 
  11. Takeshi A, Masahiko M, Takashi N, et al. 2001. Capacity of hepatic regeneration following a second partial hepatectomy in rats. Hepatology Res 21:228-241 
  12. Christian P, Luc L, Peter S, et al. 2002. Steatosis is not sufficient to cause an impaired regenerative response after partial hepatectomy in rats. Hepatology J. 32:645-652 
  13. Ralph AB, Malcolm AR, Mattew G, et al. 1998. Augmentation of the early phase of liver regeneration after 70% partial hepatectomy in rats following selective Kupffer cell depletion. J Hepatol 29:271-280 
  14. Krebs HA, Freedland RA, Hems R, et al. 1969. Inhibition of hepatic gluco-neogenesis by ethanol. Biochem J 112:117-124 
  15. Jin YS, Sa JH, Shim YH, et al. 2005. Hepatoprotective and antioxidant effects of Morus bombycis Koidzumi on $CCl_4$-induced liver damage. Biochem Biophys Res Commun 329:991-995 
  16. Zhu W, Fung PCW, 2000. The roles played by crucial free radicals like lipid free radicals, nitric oxide, and enzymes NOS and NADPH in $CCl_4$-induced acute liver injury of mice. Free Radical Biol Med 29:870-880 
  17. Yoon SH, Jung SY, Ha H. 2001. Hypoglycemic and enzyme effects of the water extract of Mori Madicis Cortex in streptozotocin-induced diabetic rats. J Korean Soc Hyg Sci 7: 119-123 
  18. Limuro Y, Nishiura T, Hellerbrand C, et al. 1998. NFkB prevents apoptosis and liver dysfunction during liver regeneration. J Clin Invest 101:802-811 

이 논문을 인용한 문헌 (0)

  1. 이 논문을 인용한 문헌 없음


원문 PDF 다운로드

  • ScienceON :

원문 URL 링크

원문 PDF 파일 및 링크정보가 존재하지 않을 경우 KISTI DDS 시스템에서 제공하는 원문복사서비스를 사용할 수 있습니다. (원문복사서비스 안내 바로 가기)

상세조회 0건 원문조회 0건

이 논문과 연관된 기능

DOI 인용 스타일