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논문 상세정보

Endotoxin Induces Late Increase in the Production of Pulmonary Proinflammatory Cytokines in Murine Lupus-Like Pristane-Primed Modelp

Abstract

Lupus-like syndrome is characterized by multiple organ injuries including lungs and kidneys. Endotoxin induces a transiently intent systemic inflammatory response and indirectly transient acute lung injury in normal condition. However, whether endotoxin may trigger the persistent development of lung injury in chronic, inflammatory lupus-like syndrome compared with normal condition remains unclear. We examined the pulmonary vascular permeability and production of proinflammatory cytokines, such as TNF-${\alpha}$, IL-6, IL-10 and IFN-${\gamma}$, which play prominent roles in the pathogenesis of lupus-like tissue injury, 6 hand 72 h after i.p. lipopolysaccharide (LPS; endotoxin) injection in pristane-primed chronic inflammation ICR mice characterized by a lupus-like syndrome. These results demonstrated that levels of serum IL-6, IL-10 and IFN-${\gamma}$ and bronchoalveolar lavage (BAL) IL-6 and IFN-${\gamma}$ were remarkably increased 6 h in LPS-exposed pristane-primed mice compared with pristane-primed controls, while pulmonary vascular permeability and levels of serum and BAL TNF-${\alpha}$ were not. And levels of BAL TNF-${\alpha}$, IL-6 and IL-10 were significantly enhanced 72 h in LPS-exposed pristane-primed mice compared with pristane-primed controls. Also, LPS significantly induced the increased in vitro production of TNF-${\alpha}$, IL-6 and IL-10 by lung cells obtained from LPS-exposed pristane-primed mice compared with LPS-exposed normal mice. Our findings indicate that LPS may trigger persistent progression of lung injury through late overproduction of BAL TNF-${\alpha}$, IL-6, and IL-10 in lupuslike chronic inflammation syndrome compared with normal condition.

참고문헌 (31)

  1. Bauer, T. T., Monton, C., Torres, A., Cabello, H., Fillela, X., Maldonado, A., Nicolas, J. M., and Zavala, E., Comparison of systemic cytokine levels in patients with acute respiratory distress syndrome, severe pneumonia, and controls. Thorax., 55, 46-52 (2000) 
  2. Childs, S. G.., The pathogenesis of systemic lupus erythematosus. Orthop. Nurs., 25, 140-145 (2006) 
  3. Christen, U. and von Herrath, M. G., Infections and autoimmunity- good or bad? J. Immunol., 174, 7481-7486 (2005) 
  4. Green, T. P., Johnson, D. E., Marchessault, R. P., and Gatto, C. W., Transvascular flux and tissue accrual of Evans blue: effects of endotoxin and histamine. J. Lab. Clin. Med., 111, 173 (1988) 
  5. Llorente, L., Zou, W., Levy, Y., Richaud-Patin, J., Wijdenes, J., Alcocer-Varela, J., Morel-Fourrier, B., Brouet, J. C., Alarcon- Segovia, D., Galanaud, P., and Emilie, D., Role of interleukin 10 in the B lymphocyte hyperactivity and autoantibody production of human systemic lupus erythematosus. J. Exp. Med., 181, 839-844 (1995) 
  6. Martinez, J. A., King, T. E. Jr., Brown, K., Jennings, C. A., Borish, L., Mortenson, R. L., Khan, T. Z., Bost, T. W., and Riches, D.W., Increased expression of the interleukin-10 gene by alveolar macrophages in interstitial lung disease. Am. J. Physiol., 273, L676-L683 (1997) 
  7. Meduri, G. U., Headley, S., Kohler, G., Stentz, F., Tolley, E., Umberger, R., and Leeper, K., Persistent elevation of inflammatory cytokines predicts a poor outcome in ARDS. Plasma IL-1 beta and IL-6 levels are consistent and efficient predictors of outcome over time. Chest, 107, 1062-73 (1995a) 
  8. Park, Y. B., Lee, S. K., Kim, D. S., Lee, J., Lee, C. H., and Song, C. H., Elevated IL-10 levels correlated with disease activity in systemic lupus erythematosus. Clin. Exp. Rheumatol., 16, 283-288 (1998) 
  9. Shacter, E., Arzadon, G. K., and Williams, J., Elevation of interleukin-6 in response to a chronic inflammatory stimulus in mice: inhibition by indomethacin. Blood, 80, 194-202 (1992) 
  10. Suter, P. M., Suter, S., Girardin, E., Roux-Lombard, P., Grau, G. E., and Dayer, J. M., High bronchoalveolar levels of tumor necrosis factor and its inhibitors, interleukin-1, interferon, and elastase, in patients with adult respiratory distress syndrome after trauma, shock, or sepsis. Am. Rev. Respir. Dis., 145, 1016-1022 (1992) 
  11. Ulich, T. R., Guo, K. Z., Remick, D., del Castillo, J., and Yin, S. M., Endotoxin-induced cytokine gene expression in vivo. III. IL-6 mRNA and serum protein expression and the in vivo hematologic effects of IL-6. J. Immunol., 146, 2316-2323 (1991) 
  12. van der Sluijs, K. F., van Elden, L. J., Nijhuis, M., Schuurman, R., Pater, J. M., Florquin, S., Goldman, M., Jansen, H. M., Lutter, R., and van der Poll, T., IL-10 is an important mediator of the enhanced susceptibility to pneumococcal pneumonia after influenza infection. J. Immunol., 172, 7603-7609 (2004) 
  13. DiCosmo, B. F., Geba, G. P., Picarella, D., Elias, J. A., Rankin, J. A., Stripp, B. R., Whitsett, J. A., and Flavell, R. A., Airway epithelial cell expression of interleukin-6 in transgenic mice. Uncoupling of airway inflammation and bronchial hyperreactivity. J. Clin. Invest., 94, 2028-2035 (1994) 
  14. Goodman, R. B., Strieter, R. M., Martin, D. P., Steinberg, K. P., Milberg, J. A., Maunder, R. J., Kunkel, S. L., Walz, A., Hudson, L. D., and Martin, T. R., Inflammatory cytokines in patients with persistence of the acute respiratory distress syndrome. Am. J. Resp. Crit. Care Med., 154, 602 (1996) 
  15. Martin, T. R., Cytokines and the acute respiratory distress syndrome (ARDS): a question of balance. Nature Med., 3, 272 (1997) 
  16. Mihara, M., Takagi, N., Takeda, Y., and Obsugi, Y., IL-6 receptor blockage inhibits the onset of autoimmune kidney disease in NZB/W F1 mice. Clin. Exp. Rheumatol. 112, 397–402 (1998) 
  17. Rojas, M., Woods, C. R., Mora, A. L., Xu, J., and Brigham, K. L., Endotoxin-induced lung injury in mice: structural, functional and biochemical responses. Am. J. Physiol. Lung Cell Mol. Physiol., 288, L333-L341 (2005) 
  18. Segal, R., Bermas, B. L., Dayan, M., Kalush, F., Shearer, G. M., and Mozes, E., Kinetics of cytokine production in experimental systemic lupus erythematosus: involvement of T helper cell 1/T helper cell 2-type cytokines in disease. J. Immunol., 158, 3009-3016 (1997) 
  19. Balomenos, D., Rumold, R., and Theofilopoulos, A. N., Interferon- gamma is required for lupus-like disease and lymphoaccumulation in MRL-lpr mice. J. Clin. Invest., 101, 364-371 (1998) 
  20. Ishida, H., Muchamuel, T., Sakaguchi, S., Andrade, S., Menson, S., and Howard, M., Continuous administration of antiinterleukin 10 antibodies delays onset of autoimmunity in NZB/W F1 mice. J. Exp. Med., 179, 305-310 (1994) 
  21. Tanita, T., Song, C., Kubo, H., Ono, S., Sagawa, M., Sato, M., Matsumura, Y., Kondo, T., and Fujimura, S., Stimulated neutrophils evoke signal transduction to increase vascular permeability in rat lungs. Tohoku J. Exp. Med., 189, 213-225 (1999) 
  22. Czermak, B. J., Breckwoldt, M., Ravage, Z. B., Huber-Lang, M., Schmal, H., Bless, N. M., Friedl, H. P., and Ward, P. A., Mechanisms of enhanced lung injury during sepsis. Am. J. Pathol., 154, 1057-1065 (1999) 
  23. Dean, G. S., Tirrell-Price, J., Crawley, E., and Isenberg, D. A., Cytokines and systemic lupus erythematosus. Ann. Rheum. Dis., 59, 243-251 (2000) 
  24. Karim, M. Y., Miranda, L. C., Tench, C. M., Gordon, P. A., D'cruz, D. P., Khamashta, M. A., and Hughes, G. R., Presentation and prognosis of the shrinking lung syndrome in systemic lupus erythematosus. Semin. Arthritis Rheum., 31, 289-298 (2002) 
  25. Malide, D., Russo, P., and Bendayan, M., Presence of tumor necrosis factor-alpha and interleukin-6 in renal mesangial cells of lupus nephritis patients. Hum. Pathol., 26, 558–564 (1995) 
  26. Anderson, B. O. and Harken, A. H., Multiple organ failure: inflammatory priming and activation sequences promote autologous tissue injury. J. Trauma., 30, S44-S49 (1990) 
  27. Barbarin. V., Xing, Z., Delos, M., Lison, D., and Huaux, F., Pulmonary overexpression of IL-10 augments lung fibrosis and Th2 responses induced by silica particles. Am. J. Physiol. Lung Cell Mol. Physiol., 288, 841-848 (2005) 
  28. Theofilopoulos, A. N., and Lawson, B. R., Tumour necrosis factor and other cytokines in murine lupus. Ann. Rheum. Dis., 58, I49-I55 (1999) 
  29. Welsh, C. H., Lien, D. C., Worthen, G. S., Henson, P. M., and Weil, J. V., Endotoxin-pretreated neutrophils increase pulmonary vascular permeability in dogs. J. Appl. Physiol., 66, 112 (1989) 
  30. Meduri, G. U., Kohler, G., Headley, S., Tolley, E., Stentz, F., and Postlethwaite, A., Inflammatory cytokines in the BAL of patients with ARDS. Persistent elevation over time predicts poor outcome. Chest, 108, 1303-1314 (1995b) 
  31. Neumann, B., Zantl, N., Veihelmann, A., Emmanuilidis, K., Pfeffer, K., Heidecke, C. D., and Holzmann, B., Mechanisms of acute inflammatory lung injury induced by abdominal sepsis. Int. Immunol., 11, 217-227 (1999) 

이 논문을 인용한 문헌 (3)

  1. 2007. "" Archives of pharmacal research : a publication of the Pharmaceutical Society of Korea, 30(4): 408~411 
  2. 2007. "" Natural product sciences, 13(3): 207~213 
  3. 2010. "" Natural product sciences, 16(4): 245~250 

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