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논문 상세정보

헛개나무로부터 생리활성물질의 추출 및 효능에 관한 연구

A Study on the Extraction and Efficacy of Bioactive Compound from Hovenia dulcis

초록

본 연구에서는 헛개나무를 숙취해소 및 간 보호 관련기능성 식품으로 개발하기 위하여 헛개나무 열매, 잎 및 줄기 추출물의 알코올 분해효과를 확인하였고, 유효 성분의 추출조건을 확립하였으며, 동물실험을 통하여 혈중 알코올농도 저하 및 간 보호 효능을 검증하였다. 헛개나무의 열매 추출물이 가장 높은 알코올 분해 효능을 보였으며 대조군에 비해 38% 알코올 감소 효과가 있었다. 헛개 열매 (크기 : 4 mm)의 회분식 추출에서 유용 생리활성물질은 추출 6시간에 평형에 도달하였으며 총 3회의 추출로 대부분의 생리활성물질을 회수(>5%)할 수 있었다. 또한 동물실험에서 헛개 열매 추출물은 혈중 알코올 농도를 현저히 감소시켰으며 사염화탄소에 의한 간 독성 유발 쥐의 간 기능 수치인 AST, ALT 및 LDH 수준을 각각 45%, 52% 및 52% 감소시켜 헛개열매 추출물이 간 보호 효과가 있음을 확인하였다.

Abstract

The biological activities of extracts from the fruit, stem, and leaf of Hovenia dulcis were examined. In the batch mode of operation, the fruit, stem, and leaf of Hovenia dulcis were extracted with hot water for 10 hr. The fruit extract of Hovenia dulcis gave the highest activity for decreasing alcohol concentration which was 138% of control. The equilibrium between bioactive compound in the fruit (size : 4 mm) and hot water solution was reached within 6 hr and the recovery was 95% by three-times extraction. The fruit extract of Hovenia dulcis showed significant alcohol decrease in blood and hepatoprotective activity against $CCl_4$-toxicity in rat. The fruit extract significantly inhibited the elevation of serum alanine aminotransferase (ALT), aspartate aminotransferase (AST), and lactate dehydrogenase (LDH) levels.

참고문헌 (12)

  1. Lee, M. K., Y. G. Kim, S. W. An, M. H. Kim, J. H. Lee, and H. Y. Lee (1999), Biological activities of Hovenia dulcis THUNB, Korean J. Medicinal Crop Sco. 7, 185-192 
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이 논문을 인용한 문헌 (10)

  1. Lee, Seon-A ; Moon, Goo 2010. "Effects of Mixture with Hovenia dulcis Thunb and Acer tegmentosum Maxim on Liver Failure Induced by D-galactosamine in Rats" 대한한방내과학회지 = The journal of internal Korean medicine, 31(1): 11~24 
  2. Kim, Sea-Hyun ; Jun, Dong-Ha ; Jang, Min-Jung ; Lee, Jin-Tae ; Lee, Chang-Eon ; Han, Jin-Gyu ; Kim, Jin-Chul ; Lee, Do-Hyung 2010. "Study of Cosmeceutical Activities of Hovenia dulcis var. koreana Nakai Extracts" 韓國林學會誌 = Journal of Korean Forest Society, 99(6): 836~842 
  3. Jung, Su-Young ; Lim, Jung-Sup ; Song, Hee-Sun 2012. "Alcohol Dehydrogenase Activity and Sensory Evaluation of Hutgae (Hovenia dulcis Thunb) Fruit Soy Sauce" 한국식품영양학회지 = The Korean journal of food and nutrition, 25(4): 747~754 
  4. Won, Sae-Bom ; Oh, Kyung-Hee ; Jung, Su-Young ; Song, Hee-Sun 2012. "Sensory Evaluation of Hutgae(Hovenia dulcis Thunb) Extract for Soy Sauce Development" 한국식품영양학회지 = The Korean journal of food and nutrition, 25(2): 266~273 
  5. Won, Sae Bom ; Song, Hee-Sun 2013. "Antioxidant Activity and Sensory Evaluation in Soy Sauce with Fruit, Stem, or Twig of Hovenia dulcis Thunb" 한국식품영양학회지 = The Korean journal of food and nutrition, 26(2): 258~265 
  6. Oh, Kyung-Hee ; Song, Hee-Sun 2013. "Sensory Evaluation of Seasoned Soy Sauce with Hutgae (Hovenia dulcis Thunb) Fruit and Pear Extracts" 한국식품영양학회지 = The Korean journal of food and nutrition, 26(2): 323~328 
  7. Kim, Young-Sik ; Park, Juyeon ; Kwon, Yongbeom ; Lim, Dong Wook ; Song, MiKyung ; Choi, Ho-Young ; Kim, Hocheol 2013. "Hepatoprotective Effects of Hovenia dulcis Extract on Acute and Chronic Liver Injuries induced by Alcohol and Carbon Tetrachloride" 大韓本草學會誌 = The Korea journal of herbology, 28(4): 25~32 
  8. Park, Sangwoug ; Kwon, Yongbeom ; Kim, Ki Tae ; Shin, Seon Mi ; Leem, Kang-Hyun ; Ko, Heung ; Song, MiKyung ; Jung, Yoon Chul ; Kim, Hocheol ; Park, Juyeon 2013. "A Randomized, Double-blind, Placebo-controlled Study to the efficacy and Safety of NMED-01 and NMED-02 in Mild Alcoholic Liver Subjects" 大韓本草學會誌 = The Korea journal of herbology, 28(6): 31~38 
  9. Choi, Ji-Young ; Kim, Jun-Han ; Kim, Gho ; Kim, Choon-Kyung ; Choi, Myung-Sook 2014. "Effect of fermented Hovenia dulcis Thunb fruit water extract on biomarker for liver injury and body weight changes in rats given oral administration of ethanol" 한국식품저장유통학회지 = Korean journal of food preservation, 21(3): 412~420 
  10. Ok, Dul-Lee ; Kim, Si-Kyung ; Lee, Seung-Cheol 2014. "Effect of Hot Water Extracts of Blue Mussel and Several Plants on Alcohol Metabolizing Enzymatic, Antioxidant, and Angiotensin Converting Enzyme Inhibitory Activities" 한국식품조리과학회지 = Korean Journal of Food & Cookery Science, 30(5): 613~619 

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